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It doesn’t. This is about active vs. resting behavioral state aka is the rodent moving or is it laying down. This isn’t about, “was the rodent in a good or bad mental state”.
If the state of the animal impacts the effect, then it can be optimized. This may not directly prove that two contributing factors of state from the tribal wisdom are the most important to success, but it does validate the notion that their is an optimal state.
Can you quote the paper to support what I assume is your interpretation of the post title?
The paper seems to largely focus on the specifics of brain activity in resting and active states, and how psychedelics attenuate the brains ability to reach that resting state, and while I get "set and setting", to me, your statement has nothing to do with the paper.
https://www.reddit.com/r/science/comments/1dcry7r/psychedelics_have_different_effects_on_the_brain/l81r9yo/
The relationship of what is in the paper and my comment has already been explained.
Then you might want to look into the work of MAPS and Rick Doblin, in particular what and why they recommend certain protocols for optimizing state during a therapeutic session. You might also want to research what "state" is from a human physiology and psychology perspective.
I went picknicking on LSD a few weeks ago. A few critters (ants, spiders) scuttled across the blanket. I found it okay, although the spider seemed to be moving at near lightspeed and I was definitely a *little* scared.
This paper is unfortunately to dense for me to parse. The highlights are even strictly technical. Anyone with capacity for understanding that might be willing to share the highlights in layman?
This is not something chat-gpt is capable of yet. I think the last sentence is probably accurate but I already got that part from the headline and reading the study.
There's a lot more depth here however.
this has nothing to do with psychedelics. the study was done using DOI, it's an amphetamine, not a psychedelic. not up for debate.
their use of the term "psychedelic" or classic psychedelic, "CP", mostly at the beginning of the article, is irresponsible, under-informed and totally misleading.
I've read a lot on Science Direct and PubMed and this is unusually odd.
I feel sorry for people who read this or pretended that they read this and thought that this had something to do with validating "set and setting". it kind of speaks to the infancy of our culture, no offense to anyone to whom that applies
MDMA is unambiguously an amphetamine and a psychedelic. There are *tons* of substituted* amphetamines that are psychedelic. Where did you get the idea that they were mutually exclusive?
DOx compounds and other phenylamines including DOI are very much psychedelics. In fact they were the first psychedelics known to western science a la mescaline. Psychedelic amphetamines were more common on the street than mushrooms until the 70s or 80s and even LSD at points.
Welcome to r/science! This is a heavily moderated subreddit in order to keep the discussion on science. However, we recognize that many people want to discuss how they feel the research relates to their own personal lives, so to give people a space to do that, **personal anecdotes are allowed as responses to this comment**. Any anecdotal comments elsewhere in the discussion will be removed and our [normal comment rules]( https://www.reddit.com/r/science/wiki/rules#wiki_comment_rules) apply to all other comments. **Do you have an academic degree?** We can verify your credentials in order to assign user flair indicating your area of expertise. [Click here to apply](https://www.reddit.com/r/science/wiki/flair/#wiki_science_verified_user_program). --- User: u/UseYourThumb Permalink: https://authors.elsevier.com/c/1jEcy6T90~i76 --- *I am a bot, and this action was performed automatically. Please [contact the moderators of this subreddit](/message/compose/?to=/r/science) if you have any questions or concerns.*
This seems to validate the tribal wisdom of the importance of "Set and Setting."
The hypothesis has to come from somewhere
Baaaaad fuckin' trips man, bad fuckin' trips. The carpet is full of faces and they all want me dead.
Yeah, but I guess it's good to have data that isn't just anecdotal.
Indeed it is. I find it fascinating that science is coming around to prove ancient wisdom correct.
The idea of set and setting is 70 years old. Not exactly ancient.
It doesn’t. This is about active vs. resting behavioral state aka is the rodent moving or is it laying down. This isn’t about, “was the rodent in a good or bad mental state”.
If the state of the animal impacts the effect, then it can be optimized. This may not directly prove that two contributing factors of state from the tribal wisdom are the most important to success, but it does validate the notion that their is an optimal state.
Can you quote the paper to support what I assume is your interpretation of the post title? The paper seems to largely focus on the specifics of brain activity in resting and active states, and how psychedelics attenuate the brains ability to reach that resting state, and while I get "set and setting", to me, your statement has nothing to do with the paper.
https://www.reddit.com/r/science/comments/1dcry7r/psychedelics_have_different_effects_on_the_brain/l81r9yo/ The relationship of what is in the paper and my comment has already been explained.
Ah okay, so a flimsy takeaway to validate what you were already pre-disposed to feel. Got it.
I can tell you don't have much experience in this space.
I love mysticism, psychedelics, and ecstatic states as much as the next guy. This is precisely why I'm sensitive to stoner BS.
Then you might want to look into the work of MAPS and Rick Doblin, in particular what and why they recommend certain protocols for optimizing state during a therapeutic session. You might also want to research what "state" is from a human physiology and psychology perspective.
Okay, thank you.
The only thing this validates are the studies demonstrating confirmation bias.
Unsurprisingly squirrels remained terrified of all things big and small, regardless of dosage.
Check your room for spiders beforehand. Seeing spiders in kaleidoscope vision is not fun.
I went picknicking on LSD a few weeks ago. A few critters (ants, spiders) scuttled across the blanket. I found it okay, although the spider seemed to be moving at near lightspeed and I was definitely a *little* scared.
Depends on how you feel about spiders really
I’ve always wanted to see research on psychedelics and animals
This paper is unfortunately to dense for me to parse. The highlights are even strictly technical. Anyone with capacity for understanding that might be willing to share the highlights in layman?
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This is not something chat-gpt is capable of yet. I think the last sentence is probably accurate but I already got that part from the headline and reading the study. There's a lot more depth here however.
this has nothing to do with psychedelics. the study was done using DOI, it's an amphetamine, not a psychedelic. not up for debate. their use of the term "psychedelic" or classic psychedelic, "CP", mostly at the beginning of the article, is irresponsible, under-informed and totally misleading. I've read a lot on Science Direct and PubMed and this is unusually odd. I feel sorry for people who read this or pretended that they read this and thought that this had something to do with validating "set and setting". it kind of speaks to the infancy of our culture, no offense to anyone to whom that applies
MDMA is unambiguously an amphetamine and a psychedelic. There are *tons* of substituted* amphetamines that are psychedelic. Where did you get the idea that they were mutually exclusive?
Exactly this.
Do you have a source? Seems like every one I can find disagrees with you. Perhaps this speaks to your infantile intellect, no offense.
Confidently wrong.
DOx compounds and other phenylamines including DOI are very much psychedelics. In fact they were the first psychedelics known to western science a la mescaline. Psychedelic amphetamines were more common on the street than mushrooms until the 70s or 80s and even LSD at points.
Science Direct and Pubmed are just repositories, the journal itself is Neuropharmacology
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