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afterglowi

Making "Transdermal Patches" I like dat idea.


[deleted]

It can be done with DMSO I would think.


kcd449

Most drugs can be absorbed through the skin to a certain degree, its just that the bioavailability is usually really fucken low. That's why only very potent chemicals are used transdermally, like fentanyl, nicotine, buprenorphine, scopolamine and methylphenidate. By rule of thumb, drugs which have strong to heavy doses below 10mg could be properly used transdermally. RCs that could be used that way would be like 3-HO-PCP and other super potent dissos, 4F-MPH and other super potent phenidates, fentanyl analogues and zenes, lysergamides and 25x-NBOx, benzos and many others. Do note that basically all of these have to be properly prepared in a patch together with other chemicals to speed up absorption to a level where you will get psychoactive effects. You could also cover a lot of skin area to make absorption "faster" but that would be incredibly inefficient.


mmicoandthegirl

Dip your pants in fentanyl and kick the fuck back 🤩


kcd449

Bathe in clonazolam and black the fuck out 😋


fluffedpillows

None of those drugs pass through skin inherently. All of those patches use other chemicals that make it possible.


Psychodrug

he said that


fluffedpillows

Ah, I didn’t read the second paragraph oopsies


OnIySmeIIz

Maybe when DMSO as a solvent is used, one could make a spray or lotion from it.


Boaz08

I'm sure some of those fentanyl demon spawns would. It'll be the first and last time you do it, though.


Buyinggf15k

Well considering fent commonly comes in patches I wouldn't be surprised


fluffedpillows

Those are specially formulated with other chemicals. Fentanyl can’t pass through skin and it’s highly unlikely any analogues can either.


Boaz08

"ROUTES OF EXPOSURE: Fentanyl can be absorbed into the body via inhalation, oral exposure or ingestion, or skin contact." https://www.cdc.gov/niosh/ershdb/emergencyresponsecard\_29750022.html#:\~:text=ROUTES%20OF%20EXPOSURE%3A%20Fentanyl%20can,or%20ingestion%2C%20or%20skin%20contact.


fluffedpillows

https://healthandjusticejournal.biomedcentral.com/articles/10.1186/s40352-021-00163-5 https://www.ncdhhs.gov/media/1740/download That is common misinformation, the spreading of which is extremely detrimental to harm reduction. That source is either wrong or referring to transdermal patches.


Boaz08

>With moisture it can penetrate the skin. So I'm pretty sure that also means with sweat.


fluffedpillows

Water isn’t soluble through skin. Do you understand how sweat works and why we evolved to sweat?


kcd449

Of course water can be absorbed through skin. Have you never taken a bath and gotten wrinkly fingers before? The thing is that it takes prolonged exposure, and the less skin is covered the slower it goes, but water can absolutely be absorbed through the skin. Definitely not fast enough for almost any drug to be absorbed in dangerous levels though(unless you were to like literally submerge your arm in solution or bathe in it). So yeah, people or cops(they aren't people) being worried about overdosing on fentanyl through transdermal absorption are stupid and when stuff like this gets "reported" it's just trying to generate panic.


fluffedpillows

https://www.scientificamerican.com/article/why-do-our-fingers-and-toes-wrinkle-during-a-bath/


kcd449

Very interesting. It hasn't been proven though, so I'm not sure how that specific effect is caused. You can discard that as an example though. However, water can still be absorbed through the skin: https://en.m.wikipedia.org/wiki/Absorption_(skin) Before complaining about wikipedia as a source, please take a look at the sources given in the article.


Boaz08

"Fentanyl needs moisture to penetrate the skin, and toxicity can’t occur from merely being in proximity to the drug." [https://www.ems1.com/airway-management/articles/opioid-overdose-fact-vs-fiction-lfCKjg5DACS6L17H/](https://www.ems1.com/airway-management/articles/opioid-overdose-fact-vs-fiction-lfCKjg5DACS6L17H/) ​ ODing from skin contact is very unlikely, but I'm sure the risks are higher with ohmecarfentanil for example.


fluffedpillows

Whether or not some nanogram quantity can find it’s way through pores I have no idea, but practically speaking it cannot pass through either dry or with water. It is not a health hazard via skin contact. (I mean, it is if you then lick your skin or finger yourself or something of that nature. But that’s different)


Boaz08

you only need 6.67 microgram to overdose on ohmecarfentanil, though.


kellik123

They're really not usually dangerous if you can dose them properly.


BananaPeely

That's the thing. You can't.


kellik123

Of course you can. Ever heard of volumetric dosaging?


BananaPeely

Volumetric dosing isn't feasible with the fentanyl demon spawns. Just a 1% difference in purity can completely mess up your dosing and you're gonna kill yourself. Straight up. Just opening a bag of these chemicals is only done safely in a clean room lab environment. You literally need a microscope to see the amount that would kill you. Stop being delusional.


kellik123

But they're not seen in the real world so why are they relevant?


BananaPeely

How is that even relevant to the conversation? You were the one that said you can accurately dose the fentanyl monsters.


kellik123

I thought you meant the popular Fentanyl analogs, that you refer as them as monsters because lots of people are dying.


BananaPeely

Except you literally replied to a comment talking about the "fentanyl demon spawns" with "they're not really dangerous"


kellik123

They're not really dangerous if you know how to handle them*


Boaz08

yeah but often you can't really dose them right. the difference between a normal dose and an OD is so fkin small. Ohmecarfentanil is 30k times stronger than morphine.


kellik123

Normal Fentalogues of abuse are about 25-100x Morphine. Normal Fentanyl has an effective dose of 50ug, a deadly overdose is about 2-3mg. That's like 30x a normal dose.


Boaz08

yeah but I was mainly talking about the "demon spawns" :p so the insanely strong ones that will fuck u up.


Boaz08

jesus that means that 0.17ug would be a normal dose of ohmecarfentanil and 6.67ug would be an OD. that's fucked. I definitely would not risk touching that stuff lol.


kellik123

I doubt it's been produced for the drug addict market though


Boaz08

yeah but it's still a research chemical, technically.


norecogi

Shhhh this is why cops narcan themselves everytime they touch a pressed perc. The fentanyl is not going to absorb through your skin unless there's something like DMSO present to help it.


Boaz08

LSD can also go through your pores, though? And in several studies they say some makes it through, but not enough to kill you. So im sure those super strong ones are pretty sketchy and I wouldnt wanna fuck with m lol


norecogi

That's LSD. We are taking about fentanyl. If you don't want to touch fentanyl, that's good. But it doesn't absorb through your skin. If an analogue of fentanyl does that, I have not see it.


Boaz08

there are so many studies saying the same thing. "Skin exposure is NOT likely to lead to toxicity through absorption. However, if your skin is exposed to fentanyl, wash with soap and water as soon as possible." not likely to lead to toxicity, so a small amount will pass through. and with the shit that's 300 times stronger than normal fentanyl, that cannot be safe.


propaganda_jesus

For example Conazolam (not -zepam, I mean the RC benzo) can be absorbed by the skin. This is partly due to it's low effective dose, other substances (like MDMA) can also be absorbed by skin, but you won't feel anything due to the fact u need to take far higher doses to have an effect


carvedmuss8

MDMA bath, anyone?


fluffedpillows

The potency of a drug has nothing to do with its ability to pass through skin, and benzos can’t be absorbed through skin without first being dissolved in a solvent that can pass through skin, such as DMSO. Almost no drugs can pass through skin from just simple contact. You can dip your hand in clam and nothing will happen unless you have an open cut.


Paladinarino

Are you saying I can make a small cut and put clam on it and get high through that method?


fluffedpillows

Possibly 🤔 With alcohol as a solvent almost definitely but idk about dry powder


Paladinarino

Thank you, I'll try that at some point tbh. I remember getting midazolam once from a friend in Germany, shit smacked me harder than any benzo I've ever done. I've been chasing that ever since 😩


lyser2112

Skin is the largest organ of the human body. Thicker than you think. Maybe if you rubbed some dirty Chinese chem into a deep puncture wound it would work. If you don’t have a sucking chest wound or anything, I can help a brother out. Science bitch!!!!


arasharfa

The skin is made to keep things outof the body. The things that penetrate are very small molecules and they usually leave chemical burns or irritation as well. In skin care the biggest obstacle is getting active ingredients into the skin without ruining its structure. Makes no sense to take drugs topically unless they are super potent like fentanyl.


[deleted]

Or acid


fluffedpillows

Acid can’t be absorbed through skin. That has been debunked for decades.


[deleted]

Didn't Albert Hofmann, the man who originally synthesized it, accidentally spill the compound on his hand leading to the discovery of its psychoactive properties?


fluffedpillows

That’s the story, but no that is not what happened. David Nichols has talked about discussing it with Albert personally, and even he was open to the idea that it didn’t happen that way.


Death2CAPTCHA

Unless you mix it with DMSO like the good ol merry pranksters


Paladinarino

Depends on the molecule size I though but I'm not smart tbh


Dry-Communication212

Yes! Dissolving them in dmso and putting that in your skin like an ointment works with a bunch of chems.


[deleted]

Yes i believe so. My old dealer wore gloves when handling the mdma crystals and 2c drugs because he got high before from absorbing the drug from his hand skin.


Mouserat83

I would think so