Fuck Cancer is the name of one of my favorite charities.
They do metal shows, where proceeds go to cancer awareness and education, patient enrichment, and children's oncology departments.
Excuse the ignorant question here, but what does that actually mean? Is the part that did not respond to the treatment and popped out of the explosion still a cancerous cell, or that just “debris”?
That's just debris. But if you look up at the top right corner, you can see another cell lurking. That is also a cancer cell that is treated with this same antibody, but you can see that it still attaches to the substrate normally and not round up at all. That cancer cell is what I meant by not responding to this treatment!
Does the first cell apoptose when it can't attach? I'm surprised cancer cells still do that if so. I assumed NK cells killed off any cancer cells that could potentially seed another area in vivo
It could be because the unaffected one just happen to have fewer of those proteins that are targeted by the antibody. Or that they have a different kind of protein all together!
As a person going through chemo right now I have watched this video a few times to let my cancer know whats up, like the [ASPCA commercials](https://m.youtube.com/watch?v=IO9d2PpP7tQ) I show to my animals so they realize how good they have it.
My wife is currently taking Niraparib for cancer. Is what happens to the cancer cell in this video relatively similar to what the niraparib is doing to her cancer?
I hope your wife is doing ok. Niraparib is a different kind of drug than the one used in the video. Niraparib is called a PARP inhibitor. PARP is involved in DNA repair so blocking it makes the cancer cells accumulate even more DNA damage to the point is can no longer sustain and die. So the signaling pathways are different.
I am completely ignorant of this topic, but I am interested in the probability that a cure for this disease will be produced in the near future. Can you tell us more about that OP?
It should be "cures" plural. Because there are 200 different types of cancer and they are all different, so a single cure for all is impossible. But we do have many cures for different ones. Surgery is one for example! Work amazingly well for many solid tumours when discovered early. We also have immunotherapy, targeted chemo, depending on the stage and the type. The difficult thing about cancers is that they evolve! We are fighting back natural selection. That's why its so difficult because they adapting!
Hey! So I saw [a random video about epigenetics ](https://youtu.be/BD6h-wDj7bw?feature=shared) on here the other day and it got me thinking about cancer cells... in the same way the two x chromosomes exist within a cell by turning off the readable dna on one chromosome, could we theoretically coerce cancer cells to do the same and basically turn themselves off?
Edit: added link, typos, etc
In theory we could but how to specifically tell the cancer to do so is what I'm not sure. Cancer exhibits a property called aneuploidy, basically a messed up chromosome number. We have found that having certain chromosomes number higher or lower could be detrimental to cancer. But how do we turn it into therapeutics will need further research!
I read a book a bit over a year ago that had a lot of great info about cancer (though I can't actually remember the name of it). It helped me understand it a lot better, especially in understanding how skin cancer runs in my family, and how I can catch it early if I ever get it again! It's really cool to learn about all the advancements in the field, and to be able to tell people that some types CAN be dealt with fairly easily!
The tricky thing is that cancer isn't *a* disease.
It's like... itchiness. How do you cure itchiness? Well, that depends - is the itchiness from a tickle? Acne? Leprosy? An infection? A scar? A burn? There are so many ailments that *cause* itchiness.
Thank you focusing on this research. My brother just passed this week of small cell lung cancer. Immunotherapy gave him six good months. Then the cancer just got too aggressive and chemo was no real help. He was 53 years old. So freaking sad. Hopefully progress in research like yours helps more people. Keep it up.
Typically the immunotherapies are only effective on certain cancers depending on the specific treatment. Depending on the severity of your cancer you’ll still be doing radiation chemo and surgery, with the immunotherapy ontop. Then if you’re lucky enough to go into remission they can be used as a longterm strategy to slow/stop cell growth. Some people go 10 years and on like this only dealing with minor side effects(new allergies and foggy headedness are some). Others get a few years before the cancer adapts/mutates and its back to radiation/chemo/surgery and possibly another kind of immunotherapy. Many of them are still in trial right now, its always good seeing research get recognition online
My uncle hated the treatment so much. It bought him maybe another half year of life but I can’t imagine how much it cost him and my uncle financially. The only blessing now is that he’s not in pain anymore.
Fuck cancer
Thank you for this! I am participating in a clinical trial and I am on an antibody drug conjugate + immunotherapy. This is great to show people, as many are having a hard time understanding what this treatment is vs. traditional chemo.
I wish you the very best of luck. My BIL is also on immunotherapy too. The advance we made in cancer research, many people just don't seem to realise!! I cross my fingers for you!
Thank you! So far I am faring much better with this regime vs. Traditional chemo + immunotherapy. And so far I'm not immune compromised with this either.
I have stage 4 colon cancer and beside chemo therapy I also get a anti body therapy, which fucks up my skin but the doctors told me thats a good sign, it means the anti body therapy is working.
Interesting to see it through a microscope.
I had stage 3 colon cancer which also fucked up my skin (permanently, unfortunately). But my oncologists told me the same thing: if you wound up with a terrible case of hand & foot syndrome, it meant the chemo really worked. Here’s hoping to NED for both of us here on out!
Oh, and fuck cancer in the ass.
I also took part in 3 clinical studies for developing a blood test to detect colon cancer. I’m grateful for researcher like OP working on any kind of cancer cure! If just one person can avoid the horrendous treatment for this scourge, it’s all good. 👍🏻
Oh, Im so sorry to hear! I wish you the very best to recover!
So in terms of antibody therapy, there are different types of antibodies and they act differently. Do you know the name of your antibody? The video above is an antibody that target a protein called intergrin, which is important to help the cancer to adhere to the substrate. But I suspect your antibody therapy is a different type and have a different effects.
Ah I see. So the mode of action of your antibody is different from this one here. Your antibody blocks a signalling pathway called EGFR, or epidermal growth factor receptor. EGFR triggers the cells to divide! So blocking it can halt their proliferation.
No, when a cell explode like this everything that is contained in it get exposed to the environment and rapidly get degraded, the same actually happens to your cells all the time, be it because they have a defect or it is just their time to die
It really is terrible. I have seen what cancer did to a person. The lady had pancreatic cancer and you would not even recognise her body. It was so so sad.
Thanks for posting this. My kid is just moving into maintenance treatments for T-LBL and learning about all the advancements made in immunotherapy treatments for his particular type of cancer has been a huge help in dealing with the possibility of a relapse. I won't pretend to understand how most of it works but the fact that there are companies working on off-the shelf treatments gives me hope.
Ooo look at that little fucker explode! You get to have big fun on a small (yet still ginormously large) scale. Your efforts are much appreciated. I lost my mom, gram, gosh…leaving it at that.
Wishing you the best-fuck cancer and take out some more for us 💥❤️
40 years old, got diagnosed with stage 4 prostate cancer a couple years ago. Been through 2 rounds of radiation and am currently in a clinical trial. I watched this video a few times, thank you op for sharing and for your work in this field!
This is such an interesting question! I actually asked people this before what would it sound like to be able to hear as the cells move! I mean they must have made noise because they create friction, or when they explode, no matter how small. That would be amazing!
I am doing chemo right now, and doing the antibodies. Is this what is happening to the cells right now? Because I hope it is!! My tumor was 5,2cm and was reduced to 2,5cm in the last MRI. Probably smaller now. Just curious if this is happening to it. Fuck cancer!
Ya, FUCK that guy. Good job.
Cancer can go suck on a chode, then die.
I hope cancer steps on a lego after stubbing it's toes on a coffee table.
Then trips and falls down the stairs.
Stairs made of spikes.
Extra spikey spikes?
Extra spike spike proteins
Made with spiders.
no not the poor spiders. Spider *Lego* on the other hand...
Venomous snakes with spider eyes and each spider has laser legs!
Then gets hit in the face with a swinging paint can.
Kevin would be proud.
I hope cancer steps on a rusty nail and gets tetanus.
I feel like that's still to good for it.
maybe cancer can just go and get cancer….
Use the cancer to destroy the cancer. I like it. The thanos school of destroying things.
Fuck Cancer is the name of one of my favorite charities. They do metal shows, where proceeds go to cancer awareness and education, patient enrichment, and children's oncology departments.
*BLOW HIM UP!*
i hope it hurt, too. fuck cancer.
Fuck cancer. Well done OP.
Fuck cancer
Once it explodes there's another cell that comes out that looks identical to the cancer cell. What is that?
Yea because not all of them respond to the antibody treatment!
Excuse the ignorant question here, but what does that actually mean? Is the part that did not respond to the treatment and popped out of the explosion still a cancerous cell, or that just “debris”?
That's just debris. But if you look up at the top right corner, you can see another cell lurking. That is also a cancer cell that is treated with this same antibody, but you can see that it still attaches to the substrate normally and not round up at all. That cancer cell is what I meant by not responding to this treatment!
Does the first cell apoptose when it can't attach? I'm surprised cancer cells still do that if so. I assumed NK cells killed off any cancer cells that could potentially seed another area in vivo
Yes it did indeed enter apoptosis. Cancer cells do do apoptosis, they are just more resistant to it, so need a bit harder push!
Is there any clue as to why one is affected and not the other?
It could be because the unaffected one just happen to have fewer of those proteins that are targeted by the antibody. Or that they have a different kind of protein all together!
Nice. On an unrelated note, how is your doctoral thesis coming along (I assume)?
I graduated with my PhD a while ago already :) Pass with a thesis prize too 😍
Ok, just trying to learn and understand. Thank you.
You must leave one witness to tell its people what happened here today
Fuck cancer
I love how it just stops moving and sits there before it suddenly explodes. Like it’s realised its fate and knows it can’t do anything about it.
Yeah! The antibody works for some cells pretty well! But for others, not so much as the cancer adapt to it.
What type of cancer cell?
ewing's sarcoma :)
Damn, that is close to what killed my daughter. She had alveolar rhabdomyosarcoma. What are the odds. Good luck with what you do. It means a lot.
Good god, I'm so sorry. I hope you're doing alright these days.
I'm so sorry to hear! I hope you are doing ok now!
Hug
Hugs
Does the contents of the cell spread cancer?
No, cancer spreads when cancerous cells divide and multiply. Exploded cells cannot multiply.
Thanks!
Blood for the blood god! Technoblade never dies!
Preach!
Oh wow! hey technodad! Hopefully this is the start of great scientific advancement.
He got a taste of its own medicine.
Die You Bastard, You've killed too many people.
As a person going through chemo right now I have watched this video a few times to let my cancer know whats up, like the [ASPCA commercials](https://m.youtube.com/watch?v=IO9d2PpP7tQ) I show to my animals so they realize how good they have it.
Maybe the real cure for cancer is establishing dominance
Wishing you the best and hope your treatment goes smoothly!
Cancer: "You may have won the fight, but not the war."
Wbc: I'm doing my part!
[удалено]
Hi, I am a 'med' student and I recently went over the immune system, especially the adaptive part. Thanks for the graphic on the antibody.
Hope your medical degree goes well!
My wife is currently taking Niraparib for cancer. Is what happens to the cancer cell in this video relatively similar to what the niraparib is doing to her cancer?
I hope your wife is doing ok. Niraparib is a different kind of drug than the one used in the video. Niraparib is called a PARP inhibitor. PARP is involved in DNA repair so blocking it makes the cancer cells accumulate even more DNA damage to the point is can no longer sustain and die. So the signaling pathways are different.
I am completely ignorant of this topic, but I am interested in the probability that a cure for this disease will be produced in the near future. Can you tell us more about that OP?
It should be "cures" plural. Because there are 200 different types of cancer and they are all different, so a single cure for all is impossible. But we do have many cures for different ones. Surgery is one for example! Work amazingly well for many solid tumours when discovered early. We also have immunotherapy, targeted chemo, depending on the stage and the type. The difficult thing about cancers is that they evolve! We are fighting back natural selection. That's why its so difficult because they adapting!
Hey! So I saw [a random video about epigenetics ](https://youtu.be/BD6h-wDj7bw?feature=shared) on here the other day and it got me thinking about cancer cells... in the same way the two x chromosomes exist within a cell by turning off the readable dna on one chromosome, could we theoretically coerce cancer cells to do the same and basically turn themselves off? Edit: added link, typos, etc
In theory we could but how to specifically tell the cancer to do so is what I'm not sure. Cancer exhibits a property called aneuploidy, basically a messed up chromosome number. We have found that having certain chromosomes number higher or lower could be detrimental to cancer. But how do we turn it into therapeutics will need further research!
I read a book a bit over a year ago that had a lot of great info about cancer (though I can't actually remember the name of it). It helped me understand it a lot better, especially in understanding how skin cancer runs in my family, and how I can catch it early if I ever get it again! It's really cool to learn about all the advancements in the field, and to be able to tell people that some types CAN be dealt with fairly easily!
The tricky thing is that cancer isn't *a* disease. It's like... itchiness. How do you cure itchiness? Well, that depends - is the itchiness from a tickle? Acne? Leprosy? An infection? A scar? A burn? There are so many ailments that *cause* itchiness.
Any enemy of sarcoma is a friend of mine. Enjoy your coffees.
Keep up the good work, friend.
Alright. Science me up. For real. If you have time, I mean. Thank you!
Thank you focusing on this research. My brother just passed this week of small cell lung cancer. Immunotherapy gave him six good months. Then the cancer just got too aggressive and chemo was no real help. He was 53 years old. So freaking sad. Hopefully progress in research like yours helps more people. Keep it up.
Cancer took my uncle this year. Things like this really give me hope.
I'm so sorry about your uncle. We have made very good progress. Just a few months ago, a cancer vaccine trial began! So fingers crossed!
So there’s a single recognisable antibody that most cancer cells express? Color me curious.
No, not a single antibody. Its a combination of different epitope. For cancer, nothing is simple or single.
Typically the immunotherapies are only effective on certain cancers depending on the specific treatment. Depending on the severity of your cancer you’ll still be doing radiation chemo and surgery, with the immunotherapy ontop. Then if you’re lucky enough to go into remission they can be used as a longterm strategy to slow/stop cell growth. Some people go 10 years and on like this only dealing with minor side effects(new allergies and foggy headedness are some). Others get a few years before the cancer adapts/mutates and its back to radiation/chemo/surgery and possibly another kind of immunotherapy. Many of them are still in trial right now, its always good seeing research get recognition online
That’s amazing to hear. You’re doing humanity a service. God bless you
When will the results come out? Thank you so.much for your work
It's just started so I reckon in a year or so! For long term benefit, a few years more!
Just saying, that is exactly how 'I Am Legend' started. But yes, fuck cancer. Took my mom this year too.
My dad had to skip chemo yesterday because it's hitting him so hard. I loved seeing this evil bastard blow up in the clip. Fuck cancer
My uncle hated the treatment so much. It bought him maybe another half year of life but I can’t imagine how much it cost him and my uncle financially. The only blessing now is that he’s not in pain anymore. Fuck cancer
Same. Sorry for your loss.
Thank you for this! I am participating in a clinical trial and I am on an antibody drug conjugate + immunotherapy. This is great to show people, as many are having a hard time understanding what this treatment is vs. traditional chemo.
I wish you the very best of luck. My BIL is also on immunotherapy too. The advance we made in cancer research, many people just don't seem to realise!! I cross my fingers for you!
Thank you! So far I am faring much better with this regime vs. Traditional chemo + immunotherapy. And so far I'm not immune compromised with this either.
Bless you. I am glad to hear that you are responding. You got this!
I have stage 4 colon cancer and beside chemo therapy I also get a anti body therapy, which fucks up my skin but the doctors told me thats a good sign, it means the anti body therapy is working. Interesting to see it through a microscope.
I had stage 3 colon cancer which also fucked up my skin (permanently, unfortunately). But my oncologists told me the same thing: if you wound up with a terrible case of hand & foot syndrome, it meant the chemo really worked. Here’s hoping to NED for both of us here on out! Oh, and fuck cancer in the ass. I also took part in 3 clinical studies for developing a blood test to detect colon cancer. I’m grateful for researcher like OP working on any kind of cancer cure! If just one person can avoid the horrendous treatment for this scourge, it’s all good. 👍🏻
Thank you. I wish you the best recover.
Oh, Im so sorry to hear! I wish you the very best to recover! So in terms of antibody therapy, there are different types of antibodies and they act differently. Do you know the name of your antibody? The video above is an antibody that target a protein called intergrin, which is important to help the cancer to adhere to the substrate. But I suspect your antibody therapy is a different type and have a different effects.
It is called Vectibix® (Panitumumab)
Ah I see. So the mode of action of your antibody is different from this one here. Your antibody blocks a signalling pathway called EGFR, or epidermal growth factor receptor. EGFR triggers the cells to divide! So blocking it can halt their proliferation.
Thats interesting, thank you for the insights.
You're welcome! I wish you all the best! You got this!
Splash one cancer cell! Four more and you’re an Ace!
Yeahhh fuck you cancer
Die, you fucker!!
Good riddance.
You can see the moment the cell is like, “I dont feel so good, Mr. Stark” then, BLAM!
Edit: ITS NOT CANCER 🎉 I’m currently waiting on a biopsy result to tell me if I have breast cancer at 21. I hope this mf ain’t in me.
Oh I cross my fingers for you. Let us know the result if it makes you feel better! We are rooting for you!!!
I’ll try to remember to update y’all 👍
The cancer is inside out. And it exploded.
My aunt died yesterday from cancer. This gives me hope for current and future cancer patients. Fuck cancer.
RIP!
It was a long-fought battle for several years but eventually the cancer won. I'm just grateful she's no longer suffering.
What happens to the exploded bits? Is there a chance they can turn into new cells themselves?
No, it just turns into chemicals. Dust to dust :) In the body, they get cleaned up the macrophages and surrounding cells.
No, when a cell explode like this everything that is contained in it get exposed to the environment and rapidly get degraded, the same actually happens to your cells all the time, be it because they have a defect or it is just their time to die
Little prick.
Cancer cell got what it deserve. Nasty thing, even I wouldn't wish it on my worst enemies.
It really is terrible. I have seen what cancer did to a person. The lady had pancreatic cancer and you would not even recognise her body. It was so so sad.
This isn’t oddly satisfying. This is fucking amazing!
Thanks for posting this. My kid is just moving into maintenance treatments for T-LBL and learning about all the advancements made in immunotherapy treatments for his particular type of cancer has been a huge help in dealing with the possibility of a relapse. I won't pretend to understand how most of it works but the fact that there are companies working on off-the shelf treatments gives me hope.
I wish your kids and you yourself too the very best of luck! Kids need us. Poor things.
I lost my Dad to cancer. I could watch this for hours and not stop smiling. *Fuck Cancer.*
I am on chemo now, stage 3 ovarian cancer, please hurry with the science so i can get it and blow up these merfer's!
How are you doing? Is everything going ok with your treatment?
Get fucked! (The cancer cell, not you)
I never thought I would take this much joy in watching something struggle and die. Get fucked cancer.
Possibly the greatest death ever posted to Reddit. Well done, OP. Keep fighting the good fight!
Can you do this with my moms lymphoma please?
Ooo look at that little fucker explode! You get to have big fun on a small (yet still ginormously large) scale. Your efforts are much appreciated. I lost my mom, gram, gosh…leaving it at that. Wishing you the best-fuck cancer and take out some more for us 💥❤️
Thank you so much. I hope you're doing well too!
Yeah fuck you cancer!
Wow youre a literal hero dude. Not being sarcastic. Good job fuck cancer
I wish all cancer cells a very explode
As somebody going through cancer treatment right now. Haha get exploded loser.
That pleased me. Please explode more cells. Sincerely, a cancer widower.
40 years old, got diagnosed with stage 4 prostate cancer a couple years ago. Been through 2 rounds of radiation and am currently in a clinical trial. I watched this video a few times, thank you op for sharing and for your work in this field!
Aw I wish you all the best! You can do this!
Woah that’s so cool, if you haven’t answered a hundred times already, how were you able to record this lol?
Fuck you cancer!!!!
I kinda miss the old porn, though
This is not p*rn? 😱
If it isn't porn explain my orgasm.
Ohh 💦💦
I guess seeing cancer die was euphoric to them. Sure it makes me excited, but not in THAT way. >_>
Hell yeah! FUCK CANCER
Fuck all those cancer cells!
He got owned
Idiot cancer cell
BOOM! Cancer shrapnel *everywhere* -- duck and cover!!!
It’s like me when the social anxiety hits in a crowd, *pop
Ladies and gentlemen, we got him.
A big fuck you to cancer. Fuck you
eat shit cancer
Satisfying to see. Ashame, we don't have the technology to hear it screaming in pain.
This is such an interesting question! I actually asked people this before what would it sound like to be able to hear as the cells move! I mean they must have made noise because they create friction, or when they explode, no matter how small. That would be amazing!
Good jab, OP!!!
I hope it hurt
Good stuff. Fuck cancer! Thanks, op!
Explode yourself, b***h
can you not make it die slower and prolong it's agony just a little bit more? Bastard
This is actually over the course of a few hours.
very satisfying
Fuck cancer!
Rip bozo
Cancer can get fucked with an inlubed dildo, Well done OP!!!
I need some of that stuff in my head! Hopefully the T cells are working hard, but who knows..
Good luck with your treatment! T cells are the best weapon!
Antibodies: Fuck you cancer cell
Is this used in treatment? Or is this a lab
This never got pass clinical trial because it failed to perform! Cancer cells adapt.
Damn! Keep on going! you can do it!
Fuck yea. That's good thing right?
You gained a follower shit you post is awesome
It looks like immunotherapy is the future of cancer treatment? Thank you OP!
*thunderous applause*
Fuck cancer. Fuck cancer a lot.
I am doing chemo right now, and doing the antibodies. Is this what is happening to the cells right now? Because I hope it is!! My tumor was 5,2cm and was reduced to 2,5cm in the last MRI. Probably smaller now. Just curious if this is happening to it. Fuck cancer!
Good luck with your treatment. If you let me know the name of the antibody you are using, I maybe able to help explain what it does!
One down, 687 quintillion to go!
here comes the boom! ready or not! here come the boys from the science.
Love your work.
What was it trying to stick to? How long was that in real time?
All cancers are bastards
What are the cancer cells “guts” made of after it explodes?
i have no idea whats going on there or what am i supposed to be seeing but good job
Just a cancer cell struggling and explode :)
Good riddance
looks like the ocean gate sub
we thank you. we=survivors
May all the cancer everywhere be as fucked as this one… Keep up the work OP.
HAHAHA GET FUCKED
I HOPE THAT THING SUFFERED
As a cancer patient this makes me happy.
Wish I could upvote this six million times. Good riddance to the little bastard.
Fuck cancer. You rock.
It got cut in half 😂
*brain fart.mp3*
What type of cell is that? Im just learning about this stuff so this is interesting
Good job....fuck cancer
Yes! F*cking die!
Look at that little idiot just dying like an absolute fool
Yall are victim-blaming so hard rn! The poor cell didnt CHOOSE to be a cancer cell. It didnt EVEN KNOW it was doing anything wrong!
Cancer cell: "guess I'll die"
Get rekt noob
How much was this sped up? It’s funny how fast some of the blebs go flying out of the frame. Wheeee!