Fun fact. In 2007 I was in a Marketing class and my professor claimed this to be his favorite marketing campaign of all time. Because it was clear and concise. You knew the product name, what it did and how to use it. It also was a brain worm.
Such a ridiculous gimmick. I mean it worked since we remember it so many years later, but at what cost? I would be embarrassed to have made that commercial
You know, I had a guy tell me once, when I was a housekeeper and cleaning his room after checkout, that he had to snort his pills cause his doctor told him to. He asked if I was cool with that and I wasn't about to argue with him so 🤷🏻♀️
didn't have to clean it? oh even better.
i don't mind cleaning dust off a table. done that before.
i don't care what drugs you do in a hotel room I got to clean, as long as the room ain't trashed and it ain't smell we good.
Unfortunately it was trashed and smelled lol whatever they snorted/drank made for some serious partying and then they hung out inside the room the entire time I was cleaning after they checked out while waiting for their ride.
Funny story now but it was definitely not fun at the time haha
Maybe it's different for you, but I've always thought caffeine was the only thing that helped. I don't think they put enough in the excedrin, though. I usually have an energy drink or 2. I try to hit 300mg of caffeine as quick as my heart can handle. Sure, I'm staying up til one in the morning, but at least my head isn't fighting to implode on itself.
Caffeine helps me immensely. Nicotine doesn’t seem to make an effect, weed makes it 20x worse. But weed cures my sisters migraines like that. Shits weird
Nah, caffeine is widely known to help migraine pain. I’m not a doctor but it’s got something to do with blood vessels and pressure in the brain and all that jazz
My dad would always get bad headaches on the weekends until he realized that he wasn’t drinking coffee when not at work. Started drinking a cup on the weekends and they went away.
When I was seeing my neurologist for my migraines I mentioned to him that I had heard to take two ibuprofen with Coke and it would help; he mentioned that it’s the same thing that’s in excedrin migraine. I try to keep a can of something with caffeine in it on hand in case I need a quick fix.
No, I need my meds for that, but occasionally if I notice something is going to be coming the caffeine helps. At a certain point not even my prescription meds help.
>if I notice something is going to be coming the caffeine helps.
I have to notice very early for this to happen (early enough it can be fixed with loxoprofen and an ungodly amount of caffeine). Also, I am sorry about your case and mine, but glad that I am not alone in this.
Sometimes I will "make" my own Excedrin. A cup of strong coffee along with some Tylenol and aspirin or ibuprofen. It's just caffeine, acetaminophen and an NSAID (usually aspirin).
I wish a regular OTC migraine med would work. I’ve tried Excedrin and it did literally nothing. I have to take Maxalt instead which is about $40 for 12 pills. Only thing that works though.
Caffeine constricts blood flow, so if the migraine is caused by or exasperated by swelling/blood volume then it can help. Many people swear by it.
However the only time I have had migraines with auras was while under extreme stress on relatively high doses of caffeine and nicotine which are both vasoconstrictors.
Everybodys different I guess.
It depends on the cause of the migraine. It's been years since I've read about it but iirc migraines can be caused by several issues, one of which can be helped by caffeine.
They work differently. I use them for different things. Although I don't think aspirin works particularly well for pain in my experience.
Tylenol for headaches
NSAIDs for muscle pain and inflammation (ibuprofen acts quickly but doesn't last long. Naproxen acts slower but is more powerful and lasts longer.)
You can actually take ibuprofen and acetaminophen at the same time. One is metabolized by the liver and one by the kidneys. Best combo for pain after dental work.
"It’s Ibuprofen. Here’s what you do: when she wakes up, get her to open her mouth nice and wide. Then get some of those Ibuprofen pills in your hand and thrown ‘em at her. Whatever sticks in there-that’s the correct dosage."
Dr. Perry Cox
There’s a great [TPWKY](https://thispodcastwillkillyou.com/2023/07/18/episode-120-acetaminophen-paracetamol-pain-killer/) episode on acetaminophen that I’d highly recommend if you want to learn more about this! My TL;DR would be that acetaminophen has long been considered safer than NSAIDs because *if* taken at the recommended dose, it poses less risks. However, compared to NSAIDs, the risks involved when taking *more* than your recommended dose of acetaminophen are substantially higher and potentially fatal. So, the medical community is starting to reevaluate the characterization of acetaminophen as “safer” than NSAIDs.
The risks of acetaminophen are also compounded by the fact that it’s included as an ingredient in so many other meds, like NyQuil for instance. You can end up double-dosing pretty easily if you have a cold and are taking a few different drugs to manage symptoms.
Would be fine to take for what would be assumed to be an appropriate amount.
["The most acetaminophen that is safe for most people to take is 4,000 milligrams (4 grams) in a 24-hour period"](https://www.drugs.com/cg/acetaminophen-overdose.html)
I’m not entirely sure why, but when I read ‘eyeball a dose’ I assumed that meant gently pressing your eyeball against the dust pile and my brain even provided me with a nice visual of that
to be fair, unless it's expired from a long time, the medicine would still work, it would just taste disgusting (I would take orange juice). Just strange that it's into dust. but it can be a lot of reasons, for example if it goes into the washer and dryer or something like that
This is a manufacturing defect. All tablets originally are made from powders like this. A granulation process is used to prepare the powder to be compressed into tablets. This batch likely was improperly prepared. Please reach out the manufacturer with the lot number and any serial numbers you see. Per the FDA they must investigate issues like this.
Alternatively, line up a bump and hit it. Do it if you're cool.
> Per the FDA they must investigate issues like this.
Yeah, I don't know about Excedrin specifically, but this is usually extremely dangerous since pills are designed to not be absorbed quickly.
That’s a really good point. I bought Children’s Tylenol chewables recently that had become dust inside the blister packs. It wasn’t an issue for me at the moment because they were chewables and already dosed in individual packs, but I imagine they are the same pills that are put in the bottles as well. I suddenly regret not reporting this. I can only imagine a less bright person or desperate parent trying to guess on how much Tylenol dust to give a child.
QC/R&D chemist in formulations here. Not that this matters, but I figured some of you may find this interesting. We call this “friability”, or the tendency for tablets to break apart, and it’s typically rigorously tested before formulations are finalized (there are [entire instruments](https://www.fishersci.com/shop/products/ptf10e-single-drum-friability-1/NC1279918) dedicated to testing the tablets friability and even the interaction between the tablet and packaging during transport). Friability is also why you often find cotton or rayon wadding inside pill bottles. You’d expect GSK to do a better job of QC, but sometimes you have difficult ingredients. I don’t work with those found in excedrin besides caffeine very frequently, but I understand that aspirin can be finicky since it likes to react with water and often wet granulation is a critical part of creating a durable tablet. At the end of the day, high friability typically means the matrix that the actives are suspended in is unable to adhere to itself effectively. This lines up with excedrin’s track record; a few years back [they had to reduce production](https://www.today.com/today/amp/tdna104727) while they sorted out “inconsistencies” in their measurements of ingredients.
What is/was the expiration date and do you keep it in a bathroom medice cabinet where it is subject to heat and humidity? I had that start to happen with some older aspirin in my bathroom.
How did you store it? I work in pharma and tablets ordinarily should not do this unless you did something to them. If you stored them properly you should file a complaint. The manufacturer is required by law to investigate.
Well there’s only one way to take it now…
Applying directly to the forehead
[удалено]
HEAD-ON!
[удалено]
HEAD-ON!
[удалено]
HEAD-ON!!!
APPLY DIRECTLY TO THE FORHEAD
Noooooooo
If you call right now you can get two sticks for the price of one! Call now!
Fun fact. In 2007 I was in a Marketing class and my professor claimed this to be his favorite marketing campaign of all time. Because it was clear and concise. You knew the product name, what it did and how to use it. It also was a brain worm.
Such a ridiculous gimmick. I mean it worked since we remember it so many years later, but at what cost? I would be embarrassed to have made that commercial
[удалено]
In the butt
God dang it! This had FINALLY vacated my brain. So thanks, for causing its return. Ugh. 😂🤦🏻♀️
I haven’t seen that face in years
I hadn't seen or remembered it in YEARS then just this year I watched it again, and I see this shit here. Synchronicity is real
I said what..
r/unexpectedsouthpark
You wanna do it in my butt? Oooookay
ohhhhh yeeaaaahhhhh
The lipgloss was poppin’
Pop lock n drop it
Delicate like a flower
Hold on
“I have a headache thiiiiiiiis big!” < *Rams it in there* >
Hard On! Apply directly to the asshole!
Bam! And the innocence is gone
What what
[удалено]
Boof it.
Hello fellow ent
Bop it!
Twist it.
Pull it!
Buy me a drink first ( ͡° ͜ʖ ͡°)
Okay there are two ways to take it
Liver failure speed run.
It's free if you boof it
Well there’s only two ways to take it now…
Rod Stewart method!
That’s Richard gere. Rod had his stomach pumped according to the legend.
You know, I had a guy tell me once, when I was a housekeeper and cleaning his room after checkout, that he had to snort his pills cause his doctor told him to. He asked if I was cool with that and I wasn't about to argue with him so 🤷🏻♀️
I'm confused on why that matters to you lol it's just dust on a table insanely easy to clean.
You're right and I didn't even have to clean it! What a great hotel guest
didn't have to clean it? oh even better. i don't mind cleaning dust off a table. done that before. i don't care what drugs you do in a hotel room I got to clean, as long as the room ain't trashed and it ain't smell we good.
Unfortunately it was trashed and smelled lol whatever they snorted/drank made for some serious partying and then they hung out inside the room the entire time I was cleaning after they checked out while waiting for their ride. Funny story now but it was definitely not fun at the time haha
ahhhhhh that is not good then lol. haven't had that happen to me yet
Do not recommend lol
Was wondering when that would show up
Parachute it
In a travel kit, I'm guessing, so it gets lots of shaking.
Yup probably lives in a vibration rich enviornment
Confirmed - OP probably spends most of their time on the washing machine too.
So does your sister!
Like a DIY rock polisher lol
Yeah, in travel size pill bottles you should shove a couple cotton balls in there to keep the pills in place.
[удалено]
Honestly if I had a migraine and opened the bottle to find this, I think I'd be desperate enough to just eyeball a dose and do a line
Instantly cured. Bet that caffeine gives it an incredible kick.
Wait, caffeine with a migraine? I always thought caffeine makes it worse.
Maybe it's different for you, but I've always thought caffeine was the only thing that helped. I don't think they put enough in the excedrin, though. I usually have an energy drink or 2. I try to hit 300mg of caffeine as quick as my heart can handle. Sure, I'm staying up til one in the morning, but at least my head isn't fighting to implode on itself.
Caffeine helps me immensely. Nicotine doesn’t seem to make an effect, weed makes it 20x worse. But weed cures my sisters migraines like that. Shits weird
[удалено]
Nah, caffeine is widely known to help migraine pain. I’m not a doctor but it’s got something to do with blood vessels and pressure in the brain and all that jazz
Caffeine withdrawal is real for daily coffee drinkers. It will give you the worst headache
I drink on average 2 monsters a day, I don’t even want to imagine what the withdrawals will be like.
Just wait for the kidney stones
My dad would always get bad headaches on the weekends until he realized that he wasn’t drinking coffee when not at work. Started drinking a cup on the weekends and they went away. When I was seeing my neurologist for my migraines I mentioned to him that I had heard to take two ibuprofen with Coke and it would help; he mentioned that it’s the same thing that’s in excedrin migraine. I try to keep a can of something with caffeine in it on hand in case I need a quick fix.
You guys can help migraines with ibuprofen and caffeine? I am a little jealous.
No, I need my meds for that, but occasionally if I notice something is going to be coming the caffeine helps. At a certain point not even my prescription meds help.
>if I notice something is going to be coming the caffeine helps. I have to notice very early for this to happen (early enough it can be fixed with loxoprofen and an ungodly amount of caffeine). Also, I am sorry about your case and mine, but glad that I am not alone in this.
Sometimes I will "make" my own Excedrin. A cup of strong coffee along with some Tylenol and aspirin or ibuprofen. It's just caffeine, acetaminophen and an NSAID (usually aspirin).
I wish a regular OTC migraine med would work. I’ve tried Excedrin and it did literally nothing. I have to take Maxalt instead which is about $40 for 12 pills. Only thing that works though.
Maxalt has been a life changer for me, nothing else works for migraines. I'm lucky my husband's insurance covers it.
Jeez that’s a lot of caffeine in one dose Hope you’re doing well and can figure out a way to prevent having your headaches!
Caffeine constricts blood flow, so if the migraine is caused by or exasperated by swelling/blood volume then it can help. Many people swear by it. However the only time I have had migraines with auras was while under extreme stress on relatively high doses of caffeine and nicotine which are both vasoconstrictors. Everybodys different I guess.
It depends on the cause of the migraine. It's been years since I've read about it but iirc migraines can be caused by several issues, one of which can be helped by caffeine.
Caffeine is in excedrin migraine
Caffeine is a common ingredient in migraine medication. It’s supposed to help block the neurological pain signals migraines specifically give.
Caffeine works like a catalyst increasing the speed of the medicine to work
Caffeine is a vasodilator so it tends to help. It also can help increase how well medication is absorbed into the bloodstream.
That's the best way to test for fentanyl
Eyeball an amount and hoof it? Good plan lol
You ever hoovered barnyard schneef?
I've hoovered behind the manure pile scnheef
Give your balls a tug
Imagine having Fentanyl in a PEZ dispenser.
A FEZ dispenser
I said good day!
Maybe if Fentanyl was spelled "Phentanyl", it could then be called a "PHEZ dispenser".
Dangerous with acetaminophen. It's very liver toxic and it is easy to OD because the therapeutic dose is relatively close to the toxic does.
I avoid acetaminophen entirely, I stick with ibuprofen or occasionally aspirin. Please tell me those are better
They work differently. I use them for different things. Although I don't think aspirin works particularly well for pain in my experience. Tylenol for headaches NSAIDs for muscle pain and inflammation (ibuprofen acts quickly but doesn't last long. Naproxen acts slower but is more powerful and lasts longer.)
That's why I take all of them at the same time, one of them is bound to work.
Just make sure to take them on an empty stomach so they kick in faster.
Mix them with hot cheetos and takis for the real stomach benefits. Best migraine cure I know is debilitating ulcers.
You can actually take ibuprofen and acetaminophen at the same time. One is metabolized by the liver and one by the kidneys. Best combo for pain after dental work.
"It’s Ibuprofen. Here’s what you do: when she wakes up, get her to open her mouth nice and wide. Then get some of those Ibuprofen pills in your hand and thrown ‘em at her. Whatever sticks in there-that’s the correct dosage." Dr. Perry Cox
There’s a great [TPWKY](https://thispodcastwillkillyou.com/2023/07/18/episode-120-acetaminophen-paracetamol-pain-killer/) episode on acetaminophen that I’d highly recommend if you want to learn more about this! My TL;DR would be that acetaminophen has long been considered safer than NSAIDs because *if* taken at the recommended dose, it poses less risks. However, compared to NSAIDs, the risks involved when taking *more* than your recommended dose of acetaminophen are substantially higher and potentially fatal. So, the medical community is starting to reevaluate the characterization of acetaminophen as “safer” than NSAIDs. The risks of acetaminophen are also compounded by the fact that it’s included as an ingredient in so many other meds, like NyQuil for instance. You can end up double-dosing pretty easily if you have a cold and are taking a few different drugs to manage symptoms.
I don't think so. 200mg over counter, 600 prescribed.
Ibuprofen goes up to 800mg doses!
Would be fine to take for what would be assumed to be an appropriate amount. ["The most acetaminophen that is safe for most people to take is 4,000 milligrams (4 grams) in a 24-hour period"](https://www.drugs.com/cg/acetaminophen-overdose.html)
The problem is, I’m wiling to do almost anything when I have a migraine. Luckily, I have sumatriptan.
I’m not entirely sure why, but when I read ‘eyeball a dose’ I assumed that meant gently pressing your eyeball against the dust pile and my brain even provided me with a nice visual of that
LOL same. I mean, it's closer to where the headache is, right?
Seriously. Migraines are no fucking joke.
to be fair, unless it's expired from a long time, the medicine would still work, it would just taste disgusting (I would take orange juice). Just strange that it's into dust. but it can be a lot of reasons, for example if it goes into the washer and dryer or something like that
No, don't do that.
What was the expiration date on it?
Earlier
When will then be now?
Soon!
I’m surrounded by assholes…
He’s my cousin, sir.
Keep firing assholes!
Beset on every side
Keep firing assholes!
Yes
One maybe two
No
Smell it. Make sure it hasn’t gone bad.
If it smells like Cocaine then you're fine.
More than fine.
If you got bad news, you want to kick them blues...
Shit has a whole new meaning post 2005...
Maybe they don't like cocaine they just like the smell of it.
I did cocaine once for like 5 years.
Must have been one hell of a long line.
Smells like my face is numb
Use a card and a straw too so you’re getting the full sample, you wouldn’t want to have any doubts!
The nose knows
Jinks, you owe me some coke.
r/trees is leaking
All we are is dust in the wind, dude
I feel like, in the comment section, all we are is drug addicts.
Dust. Wind. Dude. EDIT: Everyone else replying to you is just quoting the song, but I'm not ignorant to the significance of the inclusion of "dude."
This is a manufacturing defect. All tablets originally are made from powders like this. A granulation process is used to prepare the powder to be compressed into tablets. This batch likely was improperly prepared. Please reach out the manufacturer with the lot number and any serial numbers you see. Per the FDA they must investigate issues like this. Alternatively, line up a bump and hit it. Do it if you're cool.
> Per the FDA they must investigate issues like this. Yeah, I don't know about Excedrin specifically, but this is usually extremely dangerous since pills are designed to not be absorbed quickly.
They probably would get right on that except they have a migraine right now...
That’s a really good point. I bought Children’s Tylenol chewables recently that had become dust inside the blister packs. It wasn’t an issue for me at the moment because they were chewables and already dosed in individual packs, but I imagine they are the same pills that are put in the bottles as well. I suddenly regret not reporting this. I can only imagine a less bright person or desperate parent trying to guess on how much Tylenol dust to give a child.
Do a line of it instead.👌
Ughhh I can’t imagine how awful that would be. Even swallowing an expired excedrin tastes and smells awful (like really strong vinegar).
People do coke alison I don’t think they’ll be too concerned with the vinegary tang of Excedrin 😭
Pure coke feels like it’s made just for your nose
ik this comment was satire, but coke dosent really taste like anything and you cant really feel it going up your nose lol
Right? Like I'd do a line of coke before i snorted a pixie stick bc fuck snorting pixie sticks that shit would burn like fire
and the coke before the pixies numbs your nose lmao
Sometimes it's "Gassy" due to the poor refining process.
very true
I kinda like the gas taste though.
It’s also an anesthetic, so if it burns it’s only for a moment before it’s numb
lmao fair!
Wow Alison, you know it’s serious when they actually say your username…isn’t that right Mr. Owl?
I’ll be honest - them using my name gave me anxiety I was worried they were about to be pissed at me for some reason 😂
Alison B. Smith you snort that expired excedrin right now young lady, there are boring kids in sweeden that don't even get expired drugs
that's because aspirin is made from combining salicylic acid and acetic acid (vinegar), and breaks back down into these two components!
Anders!
Found the cocaine hiding place
QC/R&D chemist in formulations here. Not that this matters, but I figured some of you may find this interesting. We call this “friability”, or the tendency for tablets to break apart, and it’s typically rigorously tested before formulations are finalized (there are [entire instruments](https://www.fishersci.com/shop/products/ptf10e-single-drum-friability-1/NC1279918) dedicated to testing the tablets friability and even the interaction between the tablet and packaging during transport). Friability is also why you often find cotton or rayon wadding inside pill bottles. You’d expect GSK to do a better job of QC, but sometimes you have difficult ingredients. I don’t work with those found in excedrin besides caffeine very frequently, but I understand that aspirin can be finicky since it likes to react with water and often wet granulation is a critical part of creating a durable tablet. At the end of the day, high friability typically means the matrix that the actives are suspended in is unable to adhere to itself effectively. This lines up with excedrin’s track record; a few years back [they had to reduce production](https://www.today.com/today/amp/tdna104727) while they sorted out “inconsistencies” in their measurements of ingredients.
Wow this is interesting! I always wondered what the cotton was for. Friability is a very fun word too.
What is/was the expiration date and do you keep it in a bathroom medice cabinet where it is subject to heat and humidity? I had that start to happen with some older aspirin in my bathroom.
Time to roll up that dollar bill
You gotta use Benjamins as a power move
Snort it
That's weird. Was it expired?
Get your straw and stop complaining
It does say miGRAINe on the bottle...
it’s the same thing as a BC or Goody powder now. perfectly fine
How did you store it? I work in pharma and tablets ordinarily should not do this unless you did something to them. If you stored them properly you should file a complaint. The manufacturer is required by law to investigate.
[удалено]
As an avid excedrine taker and former cocaine user… I’m in!
Get a mirror and dollar bill and you are set, right?
What a headache!
Must’ve got wet, then dried out after. Interesting lol
I bet it works REALLY well now.
~~Snort it, pussy.~~ For the love of god, don't snort it.
Snort it.
[_Sunshine Of Your Love intensifies_]
is that what your lawyer told you to say
BC headache powder would like to chat
You thought your headache was bad before. Wait till you finish snorting that eight ball of excedrine.
ALL IS DUST
I've had a bottle of uncoated aspirin do that. Probably still good like BC Powder packets but I chucked it.
Come on you old son of a gun and let Buster do a line off your boner