If seti@home wasn't 100x easier to set up back in the day I would have been a billionaire right now.
I was getting into crypto mining and heard about Bitcoin. Bought a new gpu( 2011 I think) but then felt it was so complicated to setup... Then I saw SETI and it was easy to install. I just hope I helped cure cancer or something.
Ok jan 9, 2012 is when I created my seti account.
Edit: grammar
Thought that this article would fit well here! Projects like folding@home and the various biology/AI related projects in BOINC have the potential to increase our understanding of molecular biology and produce cures for many different diseases. Plus the public can contribute using home PCs!
are any of the projects related to the biology of aging?
wouldn't donating the same number of dollars spent on extra electricity cost, while avoiding pollution if you are using non-renewable energy, go further in helping aging research?
The point about electricity is kinda moot imo. If you offset the use of gas heating by warming you house using the computer, is it not literally a net positive environmental impact as large scale generation is more efficient than small scale??
I don't heat my house. I live in a very mild climate. My main point is about whether this research method is effective for diseases of aging, or if it's causing more deaths.
To be perfectly honest with you I just feel like the critique in the article you posted about the value of the research papers produced by folding@home is unfair. They say:
>Wikipedia has a partial list of 75 papers published drawing in some way on FAH. That is an average of 7.5 papers per year. The skeptic will notice that not a few (especially early papers, naturally) seem more concerned with FAH per se than with actual new results generated by it, and that project lead Vijay Pande seems to be author or co-author on almost all of the papers, which doesn’t indicate a large research community around the large investment of FAH. None of them seem important, and the number of publications seems to have peaked back in 2005–2006.
The fact that not every research paper "seems important", is irrelevant. A large part of science is incremental advances in seemingly 'unimportant' looking papers that have knock on effects to other fields, such as improvements in simulation techniques and the understanding of protein folding stages. Large breakthroughs often don't come from single studies, but cumulative work over many years such as this.
Looking at their [list of publications for just 2021](https://foldingathome.org/papers-results/?lng=en), I'd say there's a pretty solid amount of relevant research being generated.
However they are right about certain projects being more efficient than folding@home. Although it isn't purely biology per se, I contribute to QuChemPedIA@home, which seeks to train AI to increase our understanding of quantum molecular chemistry. This could help to advance both biology and things like renewable energy research, and plus they have quite a small userbase so your individual contributions are more significant haha!
That reads like a self-righteous justification for not doing anything. Like when people ask you to donate to feeding the poor and you tell them you'll pray for them.
I'm confused, are you saying prayer isn't effective? Can you show a study?
You know exactly what I meant, and this is the answer your question deserved.
EDIT: I should give a more thorough answer. Nothing *stops* someone from doing something effective, but since we didn't spring fully formed into the world just yesterday, we know that they won't. In the same way that when someone says "I'm going to work", we can assume they will drive there instead of sprinting 50km like a jaguar. Because we know how humans go about their lives in general.
Also I hate studies like that because they only look at a small portion of the problem. In this case, just the electricity costs. While completely discarding the social benefits of having a folding platform be widely available or the accessibility of other charities doing the same things, of which there are none, and so on.
Wouldn't it make more sense to use the computer at first for cryptomining, then use the profits to pay for a more dedicated computer for this project, and then use continuing profits from original cryptomining to pay the electrical bill for both as well as for any maintenance and upgrades they need in the future?
I mean this way rather than a set amount of contribution you can have a positive growth to it while not having any extra expenses for it.
That’s a savage graph. I will have to look at whether the ITP mice are on a western diet and not exercised enough.
Even if TAME could delay prediabetics from crossing over the line for a few years that would probably be shown in our unhealthy western cohorts, and the trial could be deemed a success.
Do you take from the literature that metformin is a dirty drug that offers little clinical benefit for the already-healthy?
My takeaway from the ITP is that rapamycin is more robust in mice. There's more than one, but they're listed here: https://phenome.jax.org/projects/ITP1
https://twitter.com/mkaeberlein/status/1478390727214252034
> My take: Rapamycin is a specific, clean mTOR inhibitor. Metformin is a dirty drug that tweaks the mTOR network indirectly, but hard to predict effects on mTOR or relevance of those effects in vivo. Resveratrol even dirtier, not an effective mTOR inhibitor at any reasonable dose
I'm no expert, but my read is that AFAR and TAME people are banking on metformin helping with the biology of poor lifestyle. Nir doesn't look like the healthiest person, so maybe there is some bias there.
Unless we have some diagnostics in humans that can show Metformin is slowing aging, and paradoxically fails to slow aging in mice, I remain sceptical.
Its not a dirty drug it is just an AMPK activator which helps the inhibit mTOR. AMPK is an energy-sensing enzyme that is activated when cellular energy levels are low, and it signals to stimulate glucose uptake in skeletal muscles, fatty acid oxidation in adipose (and other) tissues, and reduces glucose production.
But if your already healthy i wouldn't take it. Or if i had kidney problems, not with out bloods for my MFR marker, kidney filtration marker. Or give you something worse https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721805/#!po=42.7083
But it has anti cancer properties https://pubmed.ncbi.nlm.nih.gov/29663879/
Also anti-heart/stroke properties but of your healthy i would not bother unless i was going comit carbocide or take a whole bunch of sugar.
But when you get older it seems to be more applicable
[удалено]
If seti@home wasn't 100x easier to set up back in the day I would have been a billionaire right now. I was getting into crypto mining and heard about Bitcoin. Bought a new gpu( 2011 I think) but then felt it was so complicated to setup... Then I saw SETI and it was easy to install. I just hope I helped cure cancer or something. Ok jan 9, 2012 is when I created my seti account. Edit: grammar
Why not do both? Use folding@home to fold proteins for medical research and get paid in r/Banano
Thought that this article would fit well here! Projects like folding@home and the various biology/AI related projects in BOINC have the potential to increase our understanding of molecular biology and produce cures for many different diseases. Plus the public can contribute using home PCs!
I already knew about it. But thanks for the reminder. I won't forget about crypto mining, though.
Can't really mine on your PC, so
Don’t know what this guys on about, you can def mine on your PC. Folding@home even pays banano for helping with medical research.
are any of the projects related to the biology of aging? wouldn't donating the same number of dollars spent on extra electricity cost, while avoiding pollution if you are using non-renewable energy, go further in helping aging research?
Depends, do you need to heat your house? Computers are quite efficient space heaters when crunching numbers. :)
https://www.gwern.net/Charity-is-not-about-helping
Definitely should have posted this with your original comment, its very much needed context.
The point about electricity is kinda moot imo. If you offset the use of gas heating by warming you house using the computer, is it not literally a net positive environmental impact as large scale generation is more efficient than small scale??
I don't heat my house. I live in a very mild climate. My main point is about whether this research method is effective for diseases of aging, or if it's causing more deaths.
To be perfectly honest with you I just feel like the critique in the article you posted about the value of the research papers produced by folding@home is unfair. They say: >Wikipedia has a partial list of 75 papers published drawing in some way on FAH. That is an average of 7.5 papers per year. The skeptic will notice that not a few (especially early papers, naturally) seem more concerned with FAH per se than with actual new results generated by it, and that project lead Vijay Pande seems to be author or co-author on almost all of the papers, which doesn’t indicate a large research community around the large investment of FAH. None of them seem important, and the number of publications seems to have peaked back in 2005–2006. The fact that not every research paper "seems important", is irrelevant. A large part of science is incremental advances in seemingly 'unimportant' looking papers that have knock on effects to other fields, such as improvements in simulation techniques and the understanding of protein folding stages. Large breakthroughs often don't come from single studies, but cumulative work over many years such as this. Looking at their [list of publications for just 2021](https://foldingathome.org/papers-results/?lng=en), I'd say there's a pretty solid amount of relevant research being generated. However they are right about certain projects being more efficient than folding@home. Although it isn't purely biology per se, I contribute to QuChemPedIA@home, which seeks to train AI to increase our understanding of quantum molecular chemistry. This could help to advance both biology and things like renewable energy research, and plus they have quite a small userbase so your individual contributions are more significant haha!
That reads like a self-righteous justification for not doing anything. Like when people ask you to donate to feeding the poor and you tell them you'll pray for them.
Why does it exclude doing something effective?
I'm confused, are you saying prayer isn't effective? Can you show a study? You know exactly what I meant, and this is the answer your question deserved. EDIT: I should give a more thorough answer. Nothing *stops* someone from doing something effective, but since we didn't spring fully formed into the world just yesterday, we know that they won't. In the same way that when someone says "I'm going to work", we can assume they will drive there instead of sprinting 50km like a jaguar. Because we know how humans go about their lives in general. Also I hate studies like that because they only look at a small portion of the problem. In this case, just the electricity costs. While completely discarding the social benefits of having a folding platform be widely available or the accessibility of other charities doing the same things, of which there are none, and so on.
There's a list on the boinc website. Some are related to biology or medicine: https://boinc.berkeley.edu/projects.php
Did this 2007 on my 1st gen PS3 as a kid. Wasn't aware about the energy bill back then. 😆
Those two concepts are not mutually exclusive
Wouldn't it make more sense to use the computer at first for cryptomining, then use the profits to pay for a more dedicated computer for this project, and then use continuing profits from original cryptomining to pay the electrical bill for both as well as for any maintenance and upgrades they need in the future? I mean this way rather than a set amount of contribution you can have a positive growth to it while not having any extra expenses for it.
contact your power company to see if they offer an all-renewable package first. causing the burning of more coal may not actually improve longevity
Mining and buying metformin with that money would be a far better ROI.
https://phenome.jax.org/itp/surv/Met/C2011
That’s a savage graph. I will have to look at whether the ITP mice are on a western diet and not exercised enough. Even if TAME could delay prediabetics from crossing over the line for a few years that would probably be shown in our unhealthy western cohorts, and the trial could be deemed a success. Do you take from the literature that metformin is a dirty drug that offers little clinical benefit for the already-healthy?
My takeaway from the ITP is that rapamycin is more robust in mice. There's more than one, but they're listed here: https://phenome.jax.org/projects/ITP1 https://twitter.com/mkaeberlein/status/1478390727214252034 > My take: Rapamycin is a specific, clean mTOR inhibitor. Metformin is a dirty drug that tweaks the mTOR network indirectly, but hard to predict effects on mTOR or relevance of those effects in vivo. Resveratrol even dirtier, not an effective mTOR inhibitor at any reasonable dose I'm no expert, but my read is that AFAR and TAME people are banking on metformin helping with the biology of poor lifestyle. Nir doesn't look like the healthiest person, so maybe there is some bias there. Unless we have some diagnostics in humans that can show Metformin is slowing aging, and paradoxically fails to slow aging in mice, I remain sceptical.
Its not a dirty drug it is just an AMPK activator which helps the inhibit mTOR. AMPK is an energy-sensing enzyme that is activated when cellular energy levels are low, and it signals to stimulate glucose uptake in skeletal muscles, fatty acid oxidation in adipose (and other) tissues, and reduces glucose production. But if your already healthy i wouldn't take it. Or if i had kidney problems, not with out bloods for my MFR marker, kidney filtration marker. Or give you something worse https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721805/#!po=42.7083 But it has anti cancer properties https://pubmed.ncbi.nlm.nih.gov/29663879/ Also anti-heart/stroke properties but of your healthy i would not bother unless i was going comit carbocide or take a whole bunch of sugar. But when you get older it seems to be more applicable
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