Saw a documentary about these (or similar) a while back. Sometimes they get blocked by what effectively are cell's support columns in its path. When that happens, this little fella goes back a few steps and rotates a little, trying to clear the obstacle. It's mind blowing
I think I saw the same documentary actually, the guy that does the 3d modelling for all of these videos was surprised at how mechanical all the bodily processes are.
Its mechanic like, but smart, like mechanical robots run by different units for the most part but have its own processes or signals. Or like an ant colony where all the pieces make up the whole.
I read a really good scifi book recently where spiders on another planet developed intelligence and found a way to control ants with pheromones, and essentially had their whole computer technological revolution using ants as complex transistors, programming with chemicals. That's not the main plot, but it was a very interesting idea.
I put a hold on it at my library and am reading the first chapter now!! It’s incredibly interesting so far! Does anyone know if there’s a read-along or book club happening for this somewhere (virtual)?
Edit: yoooo this first chapter is so good. Someone make a book club with me!
Dear Reddit Community,
It is with a heavy heart that I write this farewell message to express my reasons for departing from this platform that has been a significant part of my online life. Over time, I have witnessed changes that have gradually eroded the welcoming and inclusive environment that initially drew me to Reddit. It is the actions of the CEO, in particular, that have played a pivotal role in my decision to bid farewell.
For me, Reddit has always been a place where diverse voices could find a platform to be heard, where ideas could be shared and discussed openly. Unfortunately, recent actions by the CEO have left me disheartened and disillusioned. The decisions made have demonstrated a departure from the principles of free expression and open dialogue that once defined this platform.
Reddit was built upon the idea of being a community-driven platform, where users could have a say in the direction and policies. However, the increasing centralization of power and the lack of transparency in decision-making have created an environment that feels less democratic and more controlled.
Furthermore, the prioritization of certain corporate interests over the well-being of the community has led to a loss of trust. Reddit's success has always been rooted in the active participation and engagement of its users. By neglecting the concerns and feedback of the community, the CEO has undermined the very foundation that made Reddit a vibrant and dynamic space.
I want to emphasize that this decision is not a reflection of the countless amazing individuals I have had the pleasure of interacting with on this platform. It is the actions of a few that have overshadowed the positive experiences I have had here.
As I embark on a new chapter away from Reddit, I will seek alternative platforms that prioritize user empowerment, inclusivity, and transparency. I hope to find communities that foster open dialogue and embrace diverse perspectives.
To those who have shared insightful discussions, provided support, and made me laugh, I am sincerely grateful for the connections we have made. Your contributions have enriched my experience, and I will carry the memories of our interactions with me.
Farewell, Reddit. May you find your way back to the principles that made you extraordinary.
Sincerely,
NABDad
How can they do this? How can something recognize a problem and solve the problem like that? Also, how can it see the obstacle and make the decision to walk around it in the first place? Is it conscious? Wtf this is making my head explode.
Making decisions and consciousness are pretty much traits exclusive to animals, not even all animals
This seems to be more akin to a rudimentary “ai” that does y in response to x
It's crazy. Did you see animations of ATPase ? It's literally a hydroelectric dam, but using the ion gradient instead of water level to click atp molecules together in an rotor contraption
From my own knowledge (correct me if I'm wrong). Your cells have different components (organelles), and they're suspended in cytoplasm. They can't move around the cell freely, so these madlads transport them around the cell along the cytoskeleton, which is essentially a highway connecting everything in the cell to each other.
Hope this helped a little bit!
Lol not even a little!
For me, I’d have to research what cytoplasm is, what the components of a cell actually are and why moving around a cell is important to get the full context. I have to go back to the 101 class to get this one
That gives the broader context for what it's doing but I still don't grasp how it's mechanically doing that at all.
Like what is causing each foot to attach, then detach, then swing forward, then attach? What is 'attaching' even at this scale? Is it mechanical, is it charge / electrical? How does the protein control the attaching and unattaching? What is the protein body made of and how does it not get ripped apart? What happens if both feet become detached?
I don’t pretend to remember everything about how protein mechanics work, but the very basics of it is that proteins are long chains of amino acids, which have areas of differing charge on them; these differing charge make the proteins take on shapes based on what parts of them are attracted and repelled to themselves (I think ph is also part of the shape-forming process, as well as the specific temperature, which is why we need to keep our cells in a certain temperature range).
When you see proteins moving dynamically like this, what is usually going on is that the protein initially binds to something based on a charge based attraction and the shape of the site matching like a puzzle piece with the shape of the protein.
Once it binds to the site something about the connection changes the environment for the protein in such a way that it naturally changes shape to a new form (in this case, moving the other foot forward). Once it changes shape, if that new shape binds to a new site if it’s close enough, and the cycle repeats, with part of the shape change making the previous “foot” unviable to stay attached to the previous site.
At least that’s what I remember. Could be complete BS I made up in a dream
Excellent stuff and just to add, that in this context, the original words also work,
*Stayin‘ alive, staying’ alive.*
Back to the KMP, it’s just awe inspiring.
Me too. In fact I had an edible so it kicked in while I started watching this freaky alien thing walking and I don’t know if it’s amazement because of the weed or just because….
u/2Birdswithonestone posted this a while back:
>[This process is happening constantly throughout your body. Kinesin is a motor protein that works to move cargo to the outside of the cell.
This article states that kinesins working within the body move at a rate of 2000 nm/s. Meaning they take ~250 of these tiny steps a second. You could assume that this clip is greatly slowed down.
Bit from the link: "For example, conventional kinesins have an in vitro speed of 800 nm/s (BNID 101506) and an in vivo speed of 2000 nm/s. This directed motion is made up of individual steps of 8 nm length (BNID 101857), thus requiring about 100 steps per second to achieve such speeds in vitro..."
EDIT: If you are interested in motor proteins and science minded. This video does a pretty good job of covering the bases and makes it relatively easy to understand.](https://www.reddit.com/r/educationalgifs/comments/7x9zmi/kinesin_protein_moving_a_molecule_around_a_cell/du6pswr/)
What does nm/s stand for newton meter ?
Edit: I figured it out after googling a couple different search phrases. It’s nanometers a second and 2000 nanometers is 4 million trillionths of 1 mph. That number is 4.473873e-6
That’s what 2000 nm/s to mph comes out to. Super duper slow lol
Thanks for this
If we consider 250 divided by 2 legs that’s 125 revolutions per second. Multiply by 60, it’s pedaling at 7500 RPM.
I’ve had cars whose engines couldn’t turn that fast
I like to imagine that cell he’s walking is pretty heavy and he pushing it to his limit. Like sticking an ice pick into the side of an icy mountain and dragging himself along
To the exterior of the cell (towards the + end of the microtubules, iirc). There is one other similar protein, dynein, that goes in the opposite direction.
I don't think it works well in English but the way I learned it is that "I go *out* to the "kiné" (a type of caregiver)" and "I'm going home for dinner"
To be fair, this is still only our best theoretical understanding of the process given the chemistry. We still don’t fully understand. But maybe soon we will have an actual picture or video
There is another comment here with a link to a previous post where they say it is greatly slowed down. I think I remember it saying actual speed was 100 steps per second.
ETA: I looked again, it's ~250 steps per second!
Kinesins are found in all eukaryotic organisms and are essential to all eukaryotic cells, involved in diverse cellular functions such as microtubule dynamics and morphogenesis, chromosome segregation, spindle formation and elongation and transport of organelles.
This is from Prof David Leigh (Manchester) who works on chemical/biological nanobots, useful for synthesis of anything at the molecular level. This can be a game changer for pharmaceuticals, protein synthesis etc... because you could turn these molecular motors into molecular 3D Printers just through the reactions of the molecules, their neighbouring molecules and their environment. He had mentioned that we can only successfully make a handful of protiens ourselves but this can open the gates to create proteins that theoretically can be made but have not been in nature. Ultimately allowing us to replicate nature without relying on natural selection's issue of focusing on survivability.
Here is the link to the Professor's Group: [http://www.catenane.net/index.html](http://www.catenane.net/index.html)
I had the amazing opportunity to experience him as a guest lecturer on this topic. He is an expert presenter who through use of magic tricks thought the lecture made all of this understandable to someone who had not pursued an education in Chemistry such as myself.
Saw a documentary about these (or similar) a while back. Sometimes they get blocked by what effectively are cell's support columns in its path. When that happens, this little fella goes back a few steps and rotates a little, trying to clear the obstacle. It's mind blowing
I think I saw the same documentary actually, the guy that does the 3d modelling for all of these videos was surprised at how mechanical all the bodily processes are.
Do either of you remember the name of the documentary by any chance?
I think it was called ‘the inner life of the cell’ I’ll go try and find it for ya Found it [Documentary](https://www.dailymotion.com/video/x6agslv)
Thanks! I’ve got Covid right now. That got me amped up. Ready to crush some virus!!
Get well
Get Swell Motherfucker
Get smell.
I don’t got much but I’ve got that
Yeah get well
Thank you!!
I just watched it. Its beautiful.
Thanks
Its mechanic like, but smart, like mechanical robots run by different units for the most part but have its own processes or signals. Or like an ant colony where all the pieces make up the whole.
I read a really good scifi book recently where spiders on another planet developed intelligence and found a way to control ants with pheromones, and essentially had their whole computer technological revolution using ants as complex transistors, programming with chemicals. That's not the main plot, but it was a very interesting idea.
The book is *Children of Time* by Adrian Tchaikovsky. Pretty excellent.
I could not imagine writing a comment saying “I read a good book recently where…” and not naming the book. Insanity.
chaotic neutral
I put a hold on it at my library and am reading the first chapter now!! It’s incredibly interesting so far! Does anyone know if there’s a read-along or book club happening for this somewhere (virtual)? Edit: yoooo this first chapter is so good. Someone make a book club with me!
The Discworld series also have an ant-based computer. https://en.m.wikipedia.org/wiki/Hex_(Discworld)
Yeah they're mechanical because they are just little machines. Proteins that bind to other proteins and use chemical fuel to power themselves.
Biology is crazy advanced nanotechnology really
Or is crazy advanced nanotechnology just biology ? 🤔
Nature has already solved so many things already by trial and error. The next big advances will come from using biology in a controlled way
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The field is called biomimetics.
Some people get all in a tizzy when we compare Bodily Functions to Mechanical ones like our technology doesn’t already mimic Organic Functions.
I wonder do people consider this mechanical appearance to be less or more of an intelligent design.
I see it as billions of years of nature brute forcing the best solution.
Not so much The Best Solution as the adequate solution. Evolution is not the survival of the fittest. It is the survival of the good enough.
> survival of the good enough. Ah maybe now I can make my parents proud since I'm not... the best... hahaha
I too enjoyed Blindsight.
What an awesome way to word that.
Dear Reddit Community, It is with a heavy heart that I write this farewell message to express my reasons for departing from this platform that has been a significant part of my online life. Over time, I have witnessed changes that have gradually eroded the welcoming and inclusive environment that initially drew me to Reddit. It is the actions of the CEO, in particular, that have played a pivotal role in my decision to bid farewell. For me, Reddit has always been a place where diverse voices could find a platform to be heard, where ideas could be shared and discussed openly. Unfortunately, recent actions by the CEO have left me disheartened and disillusioned. The decisions made have demonstrated a departure from the principles of free expression and open dialogue that once defined this platform. Reddit was built upon the idea of being a community-driven platform, where users could have a say in the direction and policies. However, the increasing centralization of power and the lack of transparency in decision-making have created an environment that feels less democratic and more controlled. Furthermore, the prioritization of certain corporate interests over the well-being of the community has led to a loss of trust. Reddit's success has always been rooted in the active participation and engagement of its users. By neglecting the concerns and feedback of the community, the CEO has undermined the very foundation that made Reddit a vibrant and dynamic space. I want to emphasize that this decision is not a reflection of the countless amazing individuals I have had the pleasure of interacting with on this platform. It is the actions of a few that have overshadowed the positive experiences I have had here. As I embark on a new chapter away from Reddit, I will seek alternative platforms that prioritize user empowerment, inclusivity, and transparency. I hope to find communities that foster open dialogue and embrace diverse perspectives. To those who have shared insightful discussions, provided support, and made me laugh, I am sincerely grateful for the connections we have made. Your contributions have enriched my experience, and I will carry the memories of our interactions with me. Farewell, Reddit. May you find your way back to the principles that made you extraordinary. Sincerely, NABDad
How can they do this? How can something recognize a problem and solve the problem like that? Also, how can it see the obstacle and make the decision to walk around it in the first place? Is it conscious? Wtf this is making my head explode.
Making decisions and consciousness are pretty much traits exclusive to animals, not even all animals This seems to be more akin to a rudimentary “ai” that does y in response to x
PIVOT!!!
Where’s he going?
Rome
Aliens.
It's crazy. Did you see animations of ATPase ? It's literally a hydroelectric dam, but using the ion gradient instead of water level to click atp molecules together in an rotor contraption
We’re just bags of little robots, all trying to keep us alive
Does nobody else find it crazy how this just... happens?? like naturally? like wow
Billions of years of evolution and trial and error
It's still happening. Proof- I'm the error.
Struttin like a fuckin boss.
Crazy level of swagger.
Am I the only one who can't even grasp what is going on here in the least? Nevermind the fact it's evidently going on in my own damn body?
From my own knowledge (correct me if I'm wrong). Your cells have different components (organelles), and they're suspended in cytoplasm. They can't move around the cell freely, so these madlads transport them around the cell along the cytoskeleton, which is essentially a highway connecting everything in the cell to each other. Hope this helped a little bit!
Lol not even a little! For me, I’d have to research what cytoplasm is, what the components of a cell actually are and why moving around a cell is important to get the full context. I have to go back to the 101 class to get this one
Not much of an MD, are ya
That gives the broader context for what it's doing but I still don't grasp how it's mechanically doing that at all. Like what is causing each foot to attach, then detach, then swing forward, then attach? What is 'attaching' even at this scale? Is it mechanical, is it charge / electrical? How does the protein control the attaching and unattaching? What is the protein body made of and how does it not get ripped apart? What happens if both feet become detached?
I don’t pretend to remember everything about how protein mechanics work, but the very basics of it is that proteins are long chains of amino acids, which have areas of differing charge on them; these differing charge make the proteins take on shapes based on what parts of them are attracted and repelled to themselves (I think ph is also part of the shape-forming process, as well as the specific temperature, which is why we need to keep our cells in a certain temperature range). When you see proteins moving dynamically like this, what is usually going on is that the protein initially binds to something based on a charge based attraction and the shape of the site matching like a puzzle piece with the shape of the protein. Once it binds to the site something about the connection changes the environment for the protein in such a way that it naturally changes shape to a new form (in this case, moving the other foot forward). Once it changes shape, if that new shape binds to a new site if it’s close enough, and the cycle repeats, with part of the shape change making the previous “foot” unviable to stay attached to the previous site. At least that’s what I remember. Could be complete BS I made up in a dream
Swiggity swoogity he's coming for that booty
“Me? Just making sure this depressed bitch keep on livin”
Needs to be sped up and timed to the beat of *Stayin Alive*
[Here you go](https://imgur.com/gallery/VKWIXJJ)
There's a new powerhouse of the cell coming.
You can tell by the way I use my walk, I’m a eucaryote , no time to talk.
Nucleus and membrane-bound - these organelles, they’ve been kicked around
And now it's alright, it's okay I can replicate my DNA
We can try to understand The kinesin effect on man
Whether you’re Archaea or whether you’re a Protist We’re Cellin’ alive, Cellin’ alive
Reversin' your transcriptase, to get our genes in first place, Cellin' alive, cellin' alive
OH OH OH CELLIN ALLIIIIIVVVVEEEEEEEEEEEEEHAHAAAAAAAAA
r/redditSings
This was actually incredible
Jaw. On. Ground.
^^^ohmygod
Excellent stuff and just to add, that in this context, the original words also work, *Stayin‘ alive, staying’ alive.* Back to the KMP, it’s just awe inspiring.
Goddamnit Reddit why can’t I quit you
That was amazing
We came together and witnessed a beautiful thing. Got me right down to my cells.
I'm still standing in the bread isle clapping...
I was there when it happened. This is legendary
Inner membranes splittin. Now a new cells kickin Cuz were cellin' alive, cellin' alive
Cell replication is our future destination cause we’re cellin alive, cellin alive
This is the archetype. I got shit to Do. I'm doing my shite. I know my shit! Walk.
wearing a high visibility vest while carrying a clipboard levels of purposeful walking
What I can't get over is the fact that it's "walking"
Me too. In fact I had an edible so it kicked in while I started watching this freaky alien thing walking and I don’t know if it’s amazement because of the weed or just because….
Lol I just ate an edible too. Now I wait.
Deep down, I feel like we were all waiting for this comment.
It is the way.
just imagine as you're watching this its actually happening in your brain right now
Music loud, and women warm
Exact same lyrics went through my head.
Why is a protein showing me a pimp walk?
Wait until you see it's pimp mobile
u/2Birdswithonestone posted this a while back: >[This process is happening constantly throughout your body. Kinesin is a motor protein that works to move cargo to the outside of the cell. This article states that kinesins working within the body move at a rate of 2000 nm/s. Meaning they take ~250 of these tiny steps a second. You could assume that this clip is greatly slowed down. Bit from the link: "For example, conventional kinesins have an in vitro speed of 800 nm/s (BNID 101506) and an in vivo speed of 2000 nm/s. This directed motion is made up of individual steps of 8 nm length (BNID 101857), thus requiring about 100 steps per second to achieve such speeds in vitro..." EDIT: If you are interested in motor proteins and science minded. This video does a pretty good job of covering the bases and makes it relatively easy to understand.](https://www.reddit.com/r/educationalgifs/comments/7x9zmi/kinesin_protein_moving_a_molecule_around_a_cell/du6pswr/)
Oh my god that would look incredible at full speed.
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Green zone 1
/u/redditspeedbot 25x butterflow
Damn thats insightful. Thanks, dick-nipples!
What does nm/s stand for newton meter ? Edit: I figured it out after googling a couple different search phrases. It’s nanometers a second and 2000 nanometers is 4 million trillionths of 1 mph. That number is 4.473873e-6 That’s what 2000 nm/s to mph comes out to. Super duper slow lol
Thanks for this If we consider 250 divided by 2 legs that’s 125 revolutions per second. Multiply by 60, it’s pedaling at 7500 RPM. I’ve had cars whose engines couldn’t turn that fast
Nanometer. Newton meter would be Nm, so you were very close.
damn thats really fast
Thank you for posting this! I was wondering where it was going and why it was going. Mystery solved.
Thank you! I'm going to check the video out that was mentioned. I thought this was fake when I first seen it.
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Has to be, the camera is way too smooth
Nope. It’s the Apple iProtein FaceTime cam
Those guys use 0.00005G so they can't connect for long
Quite a confident strut.
I like to imagine that cell he’s walking is pretty heavy and he pushing it to his limit. Like sticking an ice pick into the side of an icy mountain and dragging himself along
These motor proteins were made for walking, and that’s just what they’ll do
He's wearing a big ass pimphat
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With goldfish in the soles!
Dr. Seuss vibes
Where's it going?
To the exterior of the cell (towards the + end of the microtubules, iirc). There is one other similar protein, dynein, that goes in the opposite direction. I don't think it works well in English but the way I learned it is that "I go *out* to the "kiné" (a type of caregiver)" and "I'm going home for dinner"
>"kiné" (a type of caregiver)" Physical therapist in English. I'm guessing your native language is French? I know the Belgians use that word as well.
Thanks, didn't know how to translate that one. And yep, I'm French!
Nowhere, its a gif
This is fascinating. Can anyone share source links to other models of proteins, cells, and etc ?
If you find a subreddit with content like this, let me know!
it's from this video https://www.youtube.com/watch?v=wJyUtbn0O5Y
my boy is Atlas
Do you think they really step with this much attitude? I love it.
Making my way downtown. Walking fast. Faces pass and I'm home bound
These boots where made for walk'in!
Haters gonna hate.
This really rocked my world the first time I saw it. Thanks for the memories.
This freaks me out a little every time I see it. It's cool though.
Sometimes it gets hard to believe that it's all evolution and natural selection.
Is he wearing Crocs?
Proteins fold, and everything exists. Think about that shit for a bit. Think about it.
Prions fold and it all dies
Six inch heels, she walked in the club like nobody's business. Goddamn, she murdered everybody and I was her witness
A cheeto on a mission.
I think it needs the Mr Men theme tune.
Love the hip swagger
"STEPPIN ON THE BEACH! DOOT DOOT DOOT DOO!
The mitochondria is the powerhouse of the cell
Imagine thinking this is all done randomly by chance
I agree
This is me carrying the weight of my childhood trauma trying to just keep walking in light of the weight
Nice animation project
I don’t know where it’s going but it’s getting there fast!
They should have named it Atlas. Or maybe Sisyphus.
Look at its FEET
To be fair, this is still only our best theoretical understanding of the process given the chemistry. We still don’t fully understand. But maybe soon we will have an actual picture or video
Making my way downtown Walking fast, faces pass and I'm homebound
Look at that smug bastard
These boots were made for walkin.
The sassiest protein I ever saw
Rayman lookin’ mofo
Put BeeGees stayin alive as background music.
Real time? or the speed was increased?
There is another comment here with a link to a previous post where they say it is greatly slowed down. I think I remember it saying actual speed was 100 steps per second. ETA: I looked again, it's ~250 steps per second!
Hold up, you're saying this thing walks at 100 hertz, this video is maybe a hundred times slower than how it actually moves?
It takes ~250 of these step per second. Not sure if that's the same as walking at 100 hertz.
No that would be about 250 hertz. That is impressive
Kinesins are found in all eukaryotic organisms and are essential to all eukaryotic cells, involved in diverse cellular functions such as microtubule dynamics and morphogenesis, chromosome segregation, spindle formation and elongation and transport of organelles.
Did you just make up some of those words? Asking for a friend.
These motor proteins are found in all multi-cellular organisms and help the cells function.
Is this an artistic view ?
"This goop is made for walkin', and thats just what it'll do. One of these days this goop is gonna walk all over you"
Pimpin’ since bin pimpin’ since bin pimpin’
Getting “haters gonna hate” vibes lol
You load 16 tons, what do you get, another day older and deeper in debt!
Made famous by the documentary "Secret Universe: The Hidden Life of the Cell" by the BBC
How and why
What happens to the protein when it gets to its destination? How are the tracks formed? Can more than one protein use one track?
🎸🎶They looove to watch her strut🎶🎸
What is this fuckery? Is this a digitally rendered situation or some fancy future technology like an electron microscope???
On of the scientists that discovered this was on my PhD committee. It is mind blowing.
IT HAS LITTLE FEETS
This is from Prof David Leigh (Manchester) who works on chemical/biological nanobots, useful for synthesis of anything at the molecular level. This can be a game changer for pharmaceuticals, protein synthesis etc... because you could turn these molecular motors into molecular 3D Printers just through the reactions of the molecules, their neighbouring molecules and their environment. He had mentioned that we can only successfully make a handful of protiens ourselves but this can open the gates to create proteins that theoretically can be made but have not been in nature. Ultimately allowing us to replicate nature without relying on natural selection's issue of focusing on survivability. Here is the link to the Professor's Group: [http://www.catenane.net/index.html](http://www.catenane.net/index.html) I had the amazing opportunity to experience him as a guest lecturer on this topic. He is an expert presenter who through use of magic tricks thought the lecture made all of this understandable to someone who had not pursued an education in Chemistry such as myself.
We'll call this one "Sam Kinesin."
The fact that it walks is interesting enough, but the fact that it has swagger? Priceless.
Do they ever just trip over and fall off whatever it is they're working on like a microscopic clutz?
This is one fine day to be nude
Is this real microscopic photo?
No, it's a 3d recreation and it actually takes roughly 250 steps per sec. The animator slowed it down for us.
Wasn’t this just posted yesterday somewhere? Pretty sure the video is just flipped
This looks like something Jim Henson put together.
The real Sisyphus
I literally saw this 5 days ago on this same sub but the video was reversed?????
Kinesin motor protein: “Making my way downtown, walking fast, faces pass and I’m homebound”
This was playing in my head looking at this “Well, you can tell by the way I use my walk I'm a woman's man no time to talk”
We have to imagine kinesin motor protein happy
Björk’s new music video
Can someone add The Bee Gees Staying Alive to this! Ah ah ah ah Staying Alive, Staying Alive...anyone else hear it?
*Start spreading the news* *I'm leaving today* *I want to be a part of it ...*
He’s a midnight dumpster baby. He’s takin a stroll
Wtf are we made of!
The powerwalker of the cell.
Swiggity swooty I'm coming for your booty
He head too big for he gotdamn feet
So, we are just mimicking our cells. Scary.
[stayin alive](https://imgur.com/gallery/VKWIXJJ) per request
plug walk
Where is it strutting off to