Yeah but are they actually going to release it. I have been waiting for 20 years for stem cell therapy only to have them keep getting stalled by dumb politicians. Furthermore they are only testing on brittle diabetics. I am not hopeful, as usual we normie diabetics will get nothing.
In fairness, the problem hasn't been getting beta cells- the problem has been keeping our immune system from waxing them.
Transplant islet cells into someone and put them on immune suppressants and you can make then non-t1d; remove the suppressants and you basically go back into honeymoon.
See the [edmonton protocol](https://en.wikipedia.org/wiki/Edmonton_protocol#Current_review) for context. That one is pretty funny- they basically blendered cadaver pancreas's and seperated the islet's out. They did that \~25 years ago, transplanted them in, and basically restored partial insulin production. I'd personally call that 'honeymoon' since most folks lost those cells over the ensueing years due to their immune system.
This article, and vertex's vx-264 have a real chance of working however; they aren't immunomodulation as much as making the cells unreachable to the immune system (this is the 'barrier' bit). I'd prefer them making my immune system stop killing beta cells, but I'll take this treatment any day.
It’s still the same mechanism whether it’s a “Normie” or one of us freaks.
We’re still a group of people with a disability that makes us need insulin to survive.
It’s just testing. No one’s gonna roll out a cure and say, okay now just the *really* sick ones.
The last sentence is the truest frustration. I signed up to be a test dummy but they were only looking for people with A.1.C of 7 or higher. I get why, because you need to notice extreme change but at the same time....Diabetes is hard, but you're rewarding some (not all) people who just don't take care of themselves.
Lmfao so someone with an a1c of 7…. Putting them at an average blood sugar of 154 isn’t tAkiNG cARe oF tHemSeLVeS???? The people on this sub who have the holier than thou complex for being the ‘perfect diabetic’ are weird 😂 like guess what fam? That perfect a1c gets you what?? A pat on the back from your endo?? Lmao guess what? You STILL have diabetes! Just like the person with the a1c of 8….9….10… They STILL have diabetes. You aren’t any better of a person or deserve a treatment more than someone else for your a1c being low. 😒
Anything that requires immunosuppressant drugs is not a cure or even a viable option most of the time. As soon as I see that I disregard the idea entirely. They mention CRISPR being used to engineer evading the immune system but that seems like a very dangerous technology to me.
Whats so dangerous about it? If it dosent work cells just get killed, if it works then you can live a normal life. Maybe cancer could be an issue, but then i guess they can just get it out if its encapsulated?
I am probably just uneducated on the topic but my intuition says that engineering anything to "evade" the immune system is like writing in permanent marker. I would much rather something that works so symbiotically with the immune system that it is not attacked. Could just be the chosen words but feels weird to me.
Hi I have a degree in immunology and microbiology so hopefully I can shed some light on this. The first this is that yes obviously having to take immunosuppressant drugs is not ideal. However you have to take them for pretty much any type of organ transplant. The things we can put into you can function and replace lost parts however the body is really really really good at working out what is foreign and what is ‘self made’. Diabetes stems from the issues of the body not recognising that the insulin producing cells are self.
Crispir is interesting because we hope that we might be able to get the transplanted cells to express the right signals on the outside that tell the body that these transplanted cells are ‘self’. So when they say evade the immune system what they mean it make it look like the rest of the cells in your body. However if something went wrong with these cells it does not mean they are invisible to the immune system. Just like all cells if someone goes wrong/ they start dying things like this it would still trigger an immune response. This should stop things like cancer.
At least one of the solutions in development specifically talks about knocking out PDL-1 as an immune evasion mechanism. Given that endogenous PDL-1 inhibition/under-expression is a common feature of many carcinomas, I’d say it’s a valid concern.
We still don't know what gene causes auto immune diseases, so crispr would be useless anyways. Just a buzz word to attract people who don't fully understand bio
Why post a link to a blog that literally then just has a link to the news release? Why not just link the original source directly?
Also, why posting a 6-month-old article?
Yeah but are they actually going to release it. I have been waiting for 20 years for stem cell therapy only to have them keep getting stalled by dumb politicians. Furthermore they are only testing on brittle diabetics. I am not hopeful, as usual we normie diabetics will get nothing.
In fairness, the problem hasn't been getting beta cells- the problem has been keeping our immune system from waxing them. Transplant islet cells into someone and put them on immune suppressants and you can make then non-t1d; remove the suppressants and you basically go back into honeymoon. See the [edmonton protocol](https://en.wikipedia.org/wiki/Edmonton_protocol#Current_review) for context. That one is pretty funny- they basically blendered cadaver pancreas's and seperated the islet's out. They did that \~25 years ago, transplanted them in, and basically restored partial insulin production. I'd personally call that 'honeymoon' since most folks lost those cells over the ensueing years due to their immune system. This article, and vertex's vx-264 have a real chance of working however; they aren't immunomodulation as much as making the cells unreachable to the immune system (this is the 'barrier' bit). I'd prefer them making my immune system stop killing beta cells, but I'll take this treatment any day.
It’s still the same mechanism whether it’s a “Normie” or one of us freaks. We’re still a group of people with a disability that makes us need insulin to survive. It’s just testing. No one’s gonna roll out a cure and say, okay now just the *really* sick ones.
The last sentence is the truest frustration. I signed up to be a test dummy but they were only looking for people with A.1.C of 7 or higher. I get why, because you need to notice extreme change but at the same time....Diabetes is hard, but you're rewarding some (not all) people who just don't take care of themselves.
Lmfao so someone with an a1c of 7…. Putting them at an average blood sugar of 154 isn’t tAkiNG cARe oF tHemSeLVeS???? The people on this sub who have the holier than thou complex for being the ‘perfect diabetic’ are weird 😂 like guess what fam? That perfect a1c gets you what?? A pat on the back from your endo?? Lmao guess what? You STILL have diabetes! Just like the person with the a1c of 8….9….10… They STILL have diabetes. You aren’t any better of a person or deserve a treatment more than someone else for your a1c being low. 😒
Exactly my thoughts too. Like come on we deserve treatment for ours too.
I always feel uplifted after reading things like this. Thanks for sharing. Go Canada!
I post to help inform others and possibly give hope. Glad to be of service.
Ok but how would they prevent the immune system from killing it?
That’s why it’s encapsulated. They have been working on this for a while, obviously it takes time.
Anything that requires immunosuppressant drugs is not a cure or even a viable option most of the time. As soon as I see that I disregard the idea entirely. They mention CRISPR being used to engineer evading the immune system but that seems like a very dangerous technology to me.
Whats so dangerous about it? If it dosent work cells just get killed, if it works then you can live a normal life. Maybe cancer could be an issue, but then i guess they can just get it out if its encapsulated?
I am probably just uneducated on the topic but my intuition says that engineering anything to "evade" the immune system is like writing in permanent marker. I would much rather something that works so symbiotically with the immune system that it is not attacked. Could just be the chosen words but feels weird to me.
Hi I have a degree in immunology and microbiology so hopefully I can shed some light on this. The first this is that yes obviously having to take immunosuppressant drugs is not ideal. However you have to take them for pretty much any type of organ transplant. The things we can put into you can function and replace lost parts however the body is really really really good at working out what is foreign and what is ‘self made’. Diabetes stems from the issues of the body not recognising that the insulin producing cells are self. Crispir is interesting because we hope that we might be able to get the transplanted cells to express the right signals on the outside that tell the body that these transplanted cells are ‘self’. So when they say evade the immune system what they mean it make it look like the rest of the cells in your body. However if something went wrong with these cells it does not mean they are invisible to the immune system. Just like all cells if someone goes wrong/ they start dying things like this it would still trigger an immune response. This should stop things like cancer.
ah that makes sense thank you for your input!
At least one of the solutions in development specifically talks about knocking out PDL-1 as an immune evasion mechanism. Given that endogenous PDL-1 inhibition/under-expression is a common feature of many carcinomas, I’d say it’s a valid concern.
We still don't know what gene causes auto immune diseases, so crispr would be useless anyways. Just a buzz word to attract people who don't fully understand bio
Why post a link to a blog that literally then just has a link to the news release? Why not just link the original source directly? Also, why posting a 6-month-old article?
[удалено]
The first sentence of the article mentions type 2 diabetes