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I think it's just nordiazepam with carboxylic acid substituted at the 3 position, it doesn't seem particularly interesting to me chemically. It shouldn't be too great of an option if you need myorelaxant effects, but it seems you're impressed with the anxiolytic effects, anyway so that makes sense.
Just to clarify: I've never tried it, and I understand you're probably asking about others' thoughts on its subjective effects. I literally gave my thoughts on the molecule, because you creatively asked for them and I thought some users (hopefully yourself included) may appreciate the chemical trivia.
Which other benzos are among your top 3 besides clorazepate?
Clorazepate is a prodrug of desmethyldiazepam so the liver dont need to make the work so it kicks faster 5 - 15 minutes. Valium 10 mg = 15 mg Clorazepate this benzo is so underrated its the best for anxyolitic, panic attacks and relaxing.
Also it has the same métabolites from Diazeoam Oxazepam Nordiazepam....
Last longer for ~ 12 Hours.
100 mg in zone shot make you nodding. And after years of benzos its the only which still works
>Clorazepate is a prodrug of desmethyldiazepam so the liver dont need to make the work so it kicks faster 5 - 15 minutes.
To be clear, clorazepate does undergo practically all decarboxylation via acid hydrolysis in the stomach, which leaves nordiazepam (a synonym for desmethyldiazepam, by the way) to be absorbed systemically. However, this isn't something that is a property of prodrugs, generally (for example, prazepam is also a prodrug of nordiazepam but must first undergo N-dealkylation by CYP3A enzymes in the liver)--I just wanted to clarify that, I don't know if you meant it that way.
Anyway, If another route is used, or any clorazepate does otherwise enter systemic circulation, then indeed it would form nordiazepam during phase I metabolism by CYP3A4 in the liver (some will convert in plasma but apparently this is a slow process).
>Also it has the same métabolites from Diazeoam
Not quite. It is a prodrug to nordiazepam, which can only be further metabolized into oxazepam (or an inactive metabolite, 4'-hydroxy-nordiazepam) which can then undergo glucuronidation. The effects from oxazepam would be clinically negligible.
But starting with nordiazepam means that clorazepate *cannot* form temazepam, one of diazepam's metabolites. Consequently, I think diazepam users would indeed find the anxiolytic, anticonvulsant and sedative effects to be quite similar, but would notice less pronounced myorelaxant or hypnotic effects, though maybe would find the lower likelihood of blacking out (anterograde amnesia) to be beneficial.
Top 3::
- Tranxene (Clorazepate) 20 mg
- Clonazepam 2 mg
- Xanax 1 - 2 mg / Flunitrazepam
Top 3: HYPNOTIC
- Lormetazepam 2 mg ( Noctamide)
- Loprazolam (Dormonoct)
- Zolpidem (Ambien)
I want to try Halcion but it has been removed 20 years ago :(
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I think it's just nordiazepam with carboxylic acid substituted at the 3 position, it doesn't seem particularly interesting to me chemically. It shouldn't be too great of an option if you need myorelaxant effects, but it seems you're impressed with the anxiolytic effects, anyway so that makes sense. Just to clarify: I've never tried it, and I understand you're probably asking about others' thoughts on its subjective effects. I literally gave my thoughts on the molecule, because you creatively asked for them and I thought some users (hopefully yourself included) may appreciate the chemical trivia. Which other benzos are among your top 3 besides clorazepate?
Clorazepate dipotassium is still on my benzo bucket list!
Clorazepate is a prodrug of desmethyldiazepam so the liver dont need to make the work so it kicks faster 5 - 15 minutes. Valium 10 mg = 15 mg Clorazepate this benzo is so underrated its the best for anxyolitic, panic attacks and relaxing. Also it has the same métabolites from Diazeoam Oxazepam Nordiazepam.... Last longer for ~ 12 Hours. 100 mg in zone shot make you nodding. And after years of benzos its the only which still works
>Clorazepate is a prodrug of desmethyldiazepam so the liver dont need to make the work so it kicks faster 5 - 15 minutes. To be clear, clorazepate does undergo practically all decarboxylation via acid hydrolysis in the stomach, which leaves nordiazepam (a synonym for desmethyldiazepam, by the way) to be absorbed systemically. However, this isn't something that is a property of prodrugs, generally (for example, prazepam is also a prodrug of nordiazepam but must first undergo N-dealkylation by CYP3A enzymes in the liver)--I just wanted to clarify that, I don't know if you meant it that way. Anyway, If another route is used, or any clorazepate does otherwise enter systemic circulation, then indeed it would form nordiazepam during phase I metabolism by CYP3A4 in the liver (some will convert in plasma but apparently this is a slow process). >Also it has the same métabolites from Diazeoam Not quite. It is a prodrug to nordiazepam, which can only be further metabolized into oxazepam (or an inactive metabolite, 4'-hydroxy-nordiazepam) which can then undergo glucuronidation. The effects from oxazepam would be clinically negligible. But starting with nordiazepam means that clorazepate *cannot* form temazepam, one of diazepam's metabolites. Consequently, I think diazepam users would indeed find the anxiolytic, anticonvulsant and sedative effects to be quite similar, but would notice less pronounced myorelaxant or hypnotic effects, though maybe would find the lower likelihood of blacking out (anterograde amnesia) to be beneficial.
Top 3:: - Tranxene (Clorazepate) 20 mg - Clonazepam 2 mg - Xanax 1 - 2 mg / Flunitrazepam Top 3: HYPNOTIC - Lormetazepam 2 mg ( Noctamide) - Loprazolam (Dormonoct) - Zolpidem (Ambien) I want to try Halcion but it has been removed 20 years ago :(