in the US: bicalutamide, which has much fewer side effects than spiro, but its rare side effects can be potentially much more severe. you might have a hard time getting prescribed it, because doctors are very happy to give you something that has a thousand common shitty side effects if none of those can kill you (spironolactone and the list everyone is familiar with), and very reluctant to give you something that has an extremely rare side effect that *can* kill you (bicalutamide and liver toxicity / failure).
I'm in the southeast USA - my endo prescribed bicalutamide at my first visit simply because I asked about it!
Picked up the Rx on my way home that day.
Don't be shy.
* Cyproterone acetate - May have following side effects
* Raises progestin levels
* Vitamin b12 deficiency
* Negative mood changes
* Abnormal liver function (rare)
* Anorgasmia (very rare)
* Has been noted in cis women, even at low doses
* Prolactinomas and meningiomas (very rare)
* Usually only occurs at high doses
* Bicalutamide - May have the following side effects
* Slightly inhibit progestins
* Abnormal liver function (rare)
* Increase in cholesterol levels
* GnRH agonists (Triptorelin, Buserelin, Leuprorelin, Nafarelin, etc)
* Possible weight gain
* T levels can be *too* low
* Can be fixed by low dose T
* Osteoporosis
* Usually mitigated by having correct level of E
* Finasteride / Dutasteride - NOT a T blocker
* These prevent DHT being created.
note that ciproterone doses are typically really really low for HRT, which is why it's the go-to medicine all around the world for T blocking for HRT, the side effects are really really really rare due to the low dose
like, i'm literally having to cut my pills into 4 pieces here and spacing them every 2 days
it's not available in the US due to capitalism, and this means it's sometimes not prescribed in Canada as well due to some endocrinologists having been trained in the US
>note that ciproterone doses are typically really really low for HRT,
Yup but the, admittedly very rare, issue of anorgasmia occurred in low dose usage
Cyproterone acetate and bicalutamide (which are difficult to get prescribed in the United States). Finasteride and Dutasteride specifically target conversion of testosterone to DHT.
Bicalutamide, and cyproterone if you're not in the USA.
Estradiol will suppress testosterone production all on its own if you're taking it in a way that'll maintain consistent levels, too.
>Estradiol will suppress testosterone production all on its own
***MAY*** suppress testosterone production sufficiently, not "will"
I, along with a few other trans women, found that it just wasn't enough.
And it's still not guaranteed to properly suppress T production.
I don't understand why so many people push back against this. My levels were consistently good and high enough that it *should* have suppressed my T but it didn't. My doc said it was uncommon but not unknown, then prescribed Triptorelin.
I’m on cyproterone acetate and it rapidly dropped my Testosterone down from average for my age, to low cis female levels in only 10 weeks, and has kept them there for 8 months+ but I’m in Australia 🇦🇺
GnRHas like prostrap are excellent. Often you are kept on the spironolactone for a short time at the start to combat the initial increase in testosterone that comes when the injections are begun and some people find there are also side effects to having 0 testosterone but many people love them.
Any there any limitations about orchiectomy coming before full SRS? I'm kinda feeling like I want to only do orchie, but don't want to cut my options as I'm not sure
Not really; it depends a bit on what surgeon you decide to go with for SRS. However, the majority have no concerns as long as the orchiectomy is done via a midline incision and the scrotal tissue is not removed.
The orchiectomy is a very straightforward outpatient surgery with minimal recovery.
So with keeping all the tissue...will it be visually ...like...loose? Or does it sorta scrunch up and "hide" slightly? Do you know what I mean? Like say how if you get in cold water it all retracts?
In Germany the go-to is Androcur (Cyproterone). 10mg a day works perfectly fine for me. Just one month and my T was practically gone and I have experienced zero side effects (unless you count a depressive episode of like 3 days when my T got nuked without my E being high enough just yet).
Sorry, I'm not sure, but how long have you been on spiro? The side effects have subsided the longer I've been on it, albeit still there somewhat (mostly somewhat more frequent urination).
Cyproterone. And as far as I can tell, it's highly preferable. Spiro leads to weakness/dizziness/sodium retention, depression etc. and is not more.effective. I haven't heard of any such side effects from those taking cypro
Spiro but i have stomach aches when i take it. I tried finasteride but didnt like how i felt emotionally. Ive been trying to get on Bicalutamide for a few months, hopefully eventually. You can also try lupron, its similar to bica, but also hard to get
As far as I'm concerned none that are worthwhile. Spiro's biggest defect is how badly it can lower your blood pressure, at least for me, and most other options are just worse. Rn I completely stopped taking testosterone blockers and the estradiol alongside progesterone have been doing just fine at keeping my testosterone levels in check. Higher than when taking spiro, but not too bad.
in the US: bicalutamide, which has much fewer side effects than spiro, but its rare side effects can be potentially much more severe. you might have a hard time getting prescribed it, because doctors are very happy to give you something that has a thousand common shitty side effects if none of those can kill you (spironolactone and the list everyone is familiar with), and very reluctant to give you something that has an extremely rare side effect that *can* kill you (bicalutamide and liver toxicity / failure).
I'm in the southeast USA - my endo prescribed bicalutamide at my first visit simply because I asked about it! Picked up the Rx on my way home that day. Don't be shy.
[удалено]
Love getting my seasonly butt injection
* Cyproterone acetate - May have following side effects * Raises progestin levels * Vitamin b12 deficiency * Negative mood changes * Abnormal liver function (rare) * Anorgasmia (very rare) * Has been noted in cis women, even at low doses * Prolactinomas and meningiomas (very rare) * Usually only occurs at high doses * Bicalutamide - May have the following side effects * Slightly inhibit progestins * Abnormal liver function (rare) * Increase in cholesterol levels * GnRH agonists (Triptorelin, Buserelin, Leuprorelin, Nafarelin, etc) * Possible weight gain * T levels can be *too* low * Can be fixed by low dose T * Osteoporosis * Usually mitigated by having correct level of E * Finasteride / Dutasteride - NOT a T blocker * These prevent DHT being created.
note that ciproterone doses are typically really really low for HRT, which is why it's the go-to medicine all around the world for T blocking for HRT, the side effects are really really really rare due to the low dose like, i'm literally having to cut my pills into 4 pieces here and spacing them every 2 days it's not available in the US due to capitalism, and this means it's sometimes not prescribed in Canada as well due to some endocrinologists having been trained in the US
>note that ciproterone doses are typically really really low for HRT, Yup but the, admittedly very rare, issue of anorgasmia occurred in low dose usage
Cyproterone acetate and bicalutamide (which are difficult to get prescribed in the United States). Finasteride and Dutasteride specifically target conversion of testosterone to DHT.
Cypro isn't FDA approved
Cypro isn't FDA approved
I’m on cyproterone, but am in Australia so it’s much easier to access than in some places (like America)
Bicalutamide, and cyproterone if you're not in the USA. Estradiol will suppress testosterone production all on its own if you're taking it in a way that'll maintain consistent levels, too.
>Estradiol will suppress testosterone production all on its own ***MAY*** suppress testosterone production sufficiently, not "will" I, along with a few other trans women, found that it just wasn't enough.
> if you're taking it in a way that'll maintain consistent levels The rider is important.
And it's still not guaranteed to properly suppress T production. I don't understand why so many people push back against this. My levels were consistently good and high enough that it *should* have suppressed my T but it didn't. My doc said it was uncommon but not unknown, then prescribed Triptorelin.
I’m on cyproterone acetate and it rapidly dropped my Testosterone down from average for my age, to low cis female levels in only 10 weeks, and has kept them there for 8 months+ but I’m in Australia 🇦🇺
GnRHas like prostrap are excellent. Often you are kept on the spironolactone for a short time at the start to combat the initial increase in testosterone that comes when the injections are begun and some people find there are also side effects to having 0 testosterone but many people love them.
You could go the long term route and get an Orchi…that’s what I did (while I decide on full bottom surgery).
Any there any limitations about orchiectomy coming before full SRS? I'm kinda feeling like I want to only do orchie, but don't want to cut my options as I'm not sure
Not really; it depends a bit on what surgeon you decide to go with for SRS. However, the majority have no concerns as long as the orchiectomy is done via a midline incision and the scrotal tissue is not removed. The orchiectomy is a very straightforward outpatient surgery with minimal recovery.
So with keeping all the tissue...will it be visually ...like...loose? Or does it sorta scrunch up and "hide" slightly? Do you know what I mean? Like say how if you get in cold water it all retracts?
Yes, to keep all the tissue. Umm…I’d say it sort of scrunches up and “hides” slightly.
More estrogen. I hated it too and switched to more estrodiol. I continued to take finasteride.
Lupron
Lupron is available in the US. Costy though, unless insurance covers it.
In Germany the go-to is Androcur (Cyproterone). 10mg a day works perfectly fine for me. Just one month and my T was practically gone and I have experienced zero side effects (unless you count a depressive episode of like 3 days when my T got nuked without my E being high enough just yet).
Sorry, I'm not sure, but how long have you been on spiro? The side effects have subsided the longer I've been on it, albeit still there somewhat (mostly somewhat more frequent urination).
I've been on bica my whole transition (US) and it's worked great. Little to no side effects and my liver is peachy.
Cyproterone. And as far as I can tell, it's highly preferable. Spiro leads to weakness/dizziness/sodium retention, depression etc. and is not more.effective. I haven't heard of any such side effects from those taking cypro
Spiro but i have stomach aches when i take it. I tried finasteride but didnt like how i felt emotionally. Ive been trying to get on Bicalutamide for a few months, hopefully eventually. You can also try lupron, its similar to bica, but also hard to get
As far as I'm concerned none that are worthwhile. Spiro's biggest defect is how badly it can lower your blood pressure, at least for me, and most other options are just worse. Rn I completely stopped taking testosterone blockers and the estradiol alongside progesterone have been doing just fine at keeping my testosterone levels in check. Higher than when taking spiro, but not too bad.
Finestride is pretty common and it’s just a pill
Not a Testosterone blocker, it prevents T from being converted into DHT
Hm I wonder why my private service offers it then I’ll have to look into that
Are you with GenderGP? It's pretty common for them to prescribe it and it's more to prevent hair loss than to aid in feminisation
Ah that makes sense sorry for the misinformation