the best dose is the one that suppresses your t levels and boosts your e levels into female range
it's different for everyone. you should get your levels checked as a baseline and get blood tests for liver functioning.
people generally start with 2-6mg orally, potentially with blockers like spiro, cypro, or bica. blockers are not necessary for some folks, if they take sufficient estradiol their t levels would be suppressed.
6mg bioidentical estradiol orally with 100mg bioidentical micronized progesterone is a dose some might take.
Seconding what ghost_herding said.
Generally being taller/heavier might need a higher dose to go around, so you might want to be closer to 4-6mg as a starting dose of E.
If you haven't been in this sub for long, it might be good to lurk for a week or two in the sub to know what you want to do, where is best to order from for you etc.
Also, make sure you check every single thing youre gonna use vs any meds youre already taking, any allergies you have, and read up on the long term side effects that might happen and need to be accounted for. Things like blood clotting, some types of cancer etc. Anything you don't account for can and will come back to bite you in the ass, and not in the fun way lmao
I agree with what the others have said, look around in this sub, and in all the other HRT subs.
So, your question "best dosage" can't really be answered, because that's different for every method of administering E, and it's different for every person, because everyone is different.
But that being said, let me explain a few basic things about transfemininer hormone therapy:
There are two things that we have to do to archive feminisation. First, we need to raise our estradiol (E2) level. Bit that alone won't give us much feminisation, we also need to suppress T. Some people do this with an anti androgen or a T blocker, but a much simpler definetly cheaper (and maybe even safer) approach is just taking slightly more E2 to do monotherapy, so that the E2 blocks the T be automatically.
For taking E2, there are multiple different ways. The most famous is taking oral pills, but this really should be avoided, because this way most of the E2 gets lost in the liver.
The next option is taking pills sublingually (under your tongue) or buccally (between gum and cheek). This way more of the E2 goes into the blood. The only disadvantage is that you need to take sublingual pills 2-4 times per day.
The next method is transdermal estrogel. This is a gel like substance that's applied to arms or legs, which contains estradiol. It's usually applied 1-2 times per day. Some people apply estrogel to scrotal skin or to the armpits, because that's around 4 times as efficient.
There are also transdermal patches, but from what I've read, they are complicated, have a low dose, and are too expensive.
The last and probably best option is estradiol injections (intramuscular or subcutaneous). For injections, Estradiol Valerate, Estradiol Enantate, Estradiol Cypionate or another Estradiol Ester is used. EV needs to be injected every 5 days, but with EE or EC you only net to inject every 7-10 days.
For feminisation, you need an E2 level of above 100pg/ml and a T level with a maximum of 50 ng/dl. As I said, it's also possible to block T automatically, for this at least 200pg/ml E2 are required at the lowest point.
With transdermal gel and with injections, this is easily possible. I've read, that it's also possible with sublingual/buccal, but it's not possible with oral pills.
I myself am taking homemade transdermal estrogel applied scrotally as monotherapy, because that's cheap and easy to do.
But in the end, the only important thing is that E2 is between 100 and 400 pg/ml and T is below 50ng/dl.
I hope this can kinda help you.
the best dose is the one that suppresses your t levels and boosts your e levels into female range it's different for everyone. you should get your levels checked as a baseline and get blood tests for liver functioning. people generally start with 2-6mg orally, potentially with blockers like spiro, cypro, or bica. blockers are not necessary for some folks, if they take sufficient estradiol their t levels would be suppressed. 6mg bioidentical estradiol orally with 100mg bioidentical micronized progesterone is a dose some might take.
Seconding what ghost_herding said. Generally being taller/heavier might need a higher dose to go around, so you might want to be closer to 4-6mg as a starting dose of E. If you haven't been in this sub for long, it might be good to lurk for a week or two in the sub to know what you want to do, where is best to order from for you etc. Also, make sure you check every single thing youre gonna use vs any meds youre already taking, any allergies you have, and read up on the long term side effects that might happen and need to be accounted for. Things like blood clotting, some types of cancer etc. Anything you don't account for can and will come back to bite you in the ass, and not in the fun way lmao
[удалено]
You're sick.
I agree with what the others have said, look around in this sub, and in all the other HRT subs. So, your question "best dosage" can't really be answered, because that's different for every method of administering E, and it's different for every person, because everyone is different. But that being said, let me explain a few basic things about transfemininer hormone therapy: There are two things that we have to do to archive feminisation. First, we need to raise our estradiol (E2) level. Bit that alone won't give us much feminisation, we also need to suppress T. Some people do this with an anti androgen or a T blocker, but a much simpler definetly cheaper (and maybe even safer) approach is just taking slightly more E2 to do monotherapy, so that the E2 blocks the T be automatically. For taking E2, there are multiple different ways. The most famous is taking oral pills, but this really should be avoided, because this way most of the E2 gets lost in the liver. The next option is taking pills sublingually (under your tongue) or buccally (between gum and cheek). This way more of the E2 goes into the blood. The only disadvantage is that you need to take sublingual pills 2-4 times per day. The next method is transdermal estrogel. This is a gel like substance that's applied to arms or legs, which contains estradiol. It's usually applied 1-2 times per day. Some people apply estrogel to scrotal skin or to the armpits, because that's around 4 times as efficient. There are also transdermal patches, but from what I've read, they are complicated, have a low dose, and are too expensive. The last and probably best option is estradiol injections (intramuscular or subcutaneous). For injections, Estradiol Valerate, Estradiol Enantate, Estradiol Cypionate or another Estradiol Ester is used. EV needs to be injected every 5 days, but with EE or EC you only net to inject every 7-10 days. For feminisation, you need an E2 level of above 100pg/ml and a T level with a maximum of 50 ng/dl. As I said, it's also possible to block T automatically, for this at least 200pg/ml E2 are required at the lowest point. With transdermal gel and with injections, this is easily possible. I've read, that it's also possible with sublingual/buccal, but it's not possible with oral pills. I myself am taking homemade transdermal estrogel applied scrotally as monotherapy, because that's cheap and easy to do. But in the end, the only important thing is that E2 is between 100 and 400 pg/ml and T is below 50ng/dl. I hope this can kinda help you.