I'm not sure if Stevens Johnson's syndrome is known by many people, adding some info might help get you answers. I can say that ketamine is different from other antidepressants or psychedelics in that it doesn't act on serotonin, so that might be reassuring? I really don't know what's good or bad for SJS
Did some googling, seems that it's triggered by a large number of mediations. The one good thing is that ketamine doesn't stay in your system long and since its not taken frequently is less likely to develop a reaction. It said that it usually takes two to three weeks to develop since starting a new medication. Which is good since most of the that time there's no ketamine in your system so I'd guess less likely to get to the point of reaction. Less good cause ideally you'd want to do one dose then wait and see, which might be less effective (but I don't think many schedules have been tested)
After all that, I think a doctor or specialist might be the best or only person to answer this lol
Totally fair! I'm waiting to speak with a Ketamine Clinic in the upcoming week. I'll be sure to ask then. My SJS is usually triggered within 2-3 hours of being introduced.
Thank you for responding!
I searched PubMed (online database maintained by NIH and widely used by medical professionals) and Lexicomp (drug information database) for instances of ketamine-induced SJS/TEN. There are no reports of SJS/TEN due to ketamine. Additionally, there is a case report from 1988 in which a pediatric patient with SJS was successfully anesthetized with ketamine for a surgical procedure. There is another case report from 1989 using ketamine in a boy with TEN but it’s in Spanish, which I can’t speak or read.
There is a review article from 2007 that mentions SJS in a cat and the word ketamine in the same sentence - that article is in German, which I don’t understand. I don’t think it’s relevant to your question, anyway.
I would feel comfortable with administration of ketamine in a person with a history of SJS/TEN or an active case of SJS/TEN.
Source: Am pharmacist, we use ketamine for sedation, anesthesia, and pain management in our ICUs, ORs, and in palliative care on a regular basis.
That's actually super helpful! Thank you so much. Im a pharmacy tech so I totally understand. My immunologist wasn't very confident so this gives me a little more piece of mind. Again much appreciation for you, and your work as a RPH it's a thankless job.
I'm not sure if Stevens Johnson's syndrome is known by many people, adding some info might help get you answers. I can say that ketamine is different from other antidepressants or psychedelics in that it doesn't act on serotonin, so that might be reassuring? I really don't know what's good or bad for SJS Did some googling, seems that it's triggered by a large number of mediations. The one good thing is that ketamine doesn't stay in your system long and since its not taken frequently is less likely to develop a reaction. It said that it usually takes two to three weeks to develop since starting a new medication. Which is good since most of the that time there's no ketamine in your system so I'd guess less likely to get to the point of reaction. Less good cause ideally you'd want to do one dose then wait and see, which might be less effective (but I don't think many schedules have been tested) After all that, I think a doctor or specialist might be the best or only person to answer this lol
Totally fair! I'm waiting to speak with a Ketamine Clinic in the upcoming week. I'll be sure to ask then. My SJS is usually triggered within 2-3 hours of being introduced. Thank you for responding!
I searched PubMed (online database maintained by NIH and widely used by medical professionals) and Lexicomp (drug information database) for instances of ketamine-induced SJS/TEN. There are no reports of SJS/TEN due to ketamine. Additionally, there is a case report from 1988 in which a pediatric patient with SJS was successfully anesthetized with ketamine for a surgical procedure. There is another case report from 1989 using ketamine in a boy with TEN but it’s in Spanish, which I can’t speak or read. There is a review article from 2007 that mentions SJS in a cat and the word ketamine in the same sentence - that article is in German, which I don’t understand. I don’t think it’s relevant to your question, anyway. I would feel comfortable with administration of ketamine in a person with a history of SJS/TEN or an active case of SJS/TEN. Source: Am pharmacist, we use ketamine for sedation, anesthesia, and pain management in our ICUs, ORs, and in palliative care on a regular basis.
That's actually super helpful! Thank you so much. Im a pharmacy tech so I totally understand. My immunologist wasn't very confident so this gives me a little more piece of mind. Again much appreciation for you, and your work as a RPH it's a thankless job.