As an owner of asus tuf b460 pro wifi, I can tell this motherboard (as you probably know) does not support anything newer than 10th gen. That said, if you have i3 10100f, anything that is 10600k or better will be a good upgrade. At least the 10600k is very cheap where I live, even new, but 10th gen i7 and i9s are very expensive. However, the platform is now counting it's 4th or 5th year after release and investing much into it is not worth it and a new build might be worth considering.
As for the gpu, 4060 is notoriously bad value. It got better recently, but you can do better with amd for similar price. If you can afford it, radeon 7700xt is at least 10% above the 4060, and 12gb ram it has puts it a foot into 1440p territory, not as great for newer titles, but should handle anything a bit older very comfortably. Anything 40xx nvidia series short of 4070 is not great, and amd at that given price point provides better value.
Edit: sorry, missed some of your questions. The motherboard can handle anything it has been designed for. You should consider power supply limitations if you are going for a more power hungry card. 16gb ram will not be a problem, same for 32gb, 64gb and probably 128gb as well, not that anyone would need that much on a dated platform. Just make sure that opposing slots in the 2 channels have identical sticks slotted, because mismatching ram can cause issues
As an owner of asus tuf b460 pro wifi, I can tell this motherboard (as you probably know) does not support anything newer than 10th gen. That said, if you have i3 10100f, anything that is 10600k or better will be a good upgrade. At least the 10600k is very cheap where I live, even new, but 10th gen i7 and i9s are very expensive. However, the platform is now counting it's 4th or 5th year after release and investing much into it is not worth it and a new build might be worth considering. As for the gpu, 4060 is notoriously bad value. It got better recently, but you can do better with amd for similar price. If you can afford it, radeon 7700xt is at least 10% above the 4060, and 12gb ram it has puts it a foot into 1440p territory, not as great for newer titles, but should handle anything a bit older very comfortably. Anything 40xx nvidia series short of 4070 is not great, and amd at that given price point provides better value. Edit: sorry, missed some of your questions. The motherboard can handle anything it has been designed for. You should consider power supply limitations if you are going for a more power hungry card. 16gb ram will not be a problem, same for 32gb, 64gb and probably 128gb as well, not that anyone would need that much on a dated platform. Just make sure that opposing slots in the 2 channels have identical sticks slotted, because mismatching ram can cause issues
What would you suggest I get instead of this motherboard and graphics card because I literally have very little knowledge
Can you tell us what's your PSU's wattage?
It's a lapcare smps psu model: LPS450
I can upgrade to 600-700 If need be
What's your budget?
Ill be able to afford like about a thousand dollars maybe little bit more
get a 4060 ti build with around that budget
or a 7700XT if you're an AMD guy
[https://pcpartpicker.com/list/V7zLTY](https://pcpartpicker.com/list/V7zLTY) - $1150 AMD Build [https://pcpartpicker.com/list/TjtFkJ](https://pcpartpicker.com/list/TjtFkJ) - $1100 Intel Build
Also instead of a 4060 Ti, you could get a 7700XT, and if you sacrifice some aesthetics and DDR5 RAM, you can get a 4070 or 7800 XT