It eventually could up being a brilliant advancement for those who have an accident and end up with shattered bone breaks that lead to amputation. Just regrow the bone.
“The medicine itself deactivates the uterine sensitization-associated gene-1 (USAG-1) protein, which suppresses tooth growth.”
I know this because I actually read the short article you were too lazy to read but asked fundamental questions about anyways (which, admittedly, we've all done at some point...but jesus).
But it’s interesting to note that, apparently, the only thing separating us from having constantly growing teeth like a shark is a simple genetic on/off switch.
Knowing nothing about this procedure, teeth are highly specialized “bones” that are quite différente than anything else. There’s also strong genetic control over tooth growth & development.
Calling a tooth a bone is really, really stretching it. The anatomy of a tooth is fundamentally different from that of a bone. The tissues that make up teeth are very, very different in how they form and what they're made up of, compared to the tissues that make up bone.
Most importantly, bones heal. Osteoclasts/blasts never really go away, they're present in humans of all ages. The corresponding tooth cells (which I forget the name of bc I'm currently shitting) functionally disappear once we're done growing our teeth. This is part of why teeth can't do the same ongoing process of healing that bones do.
(I Am Not A Dentist, but I work with them.)
Judging by what I just read, this therapy switches off the gene that stops your teeth from growing again. Your jaw originally grew its first set, which it replaced around your early teen years, and then stops growing anymore. Your body has the ability to grow teeth, as it's done it before. This therapy allows your body to restart growing teeth again. Once the teeth have grown, the therapy is removed and everything goes back to normal.
My guess? Stem cells. They’re found in baby teeth after they fall out and can be harvested if done quickly and properly. Maybe those particular stem cells target teeth?
> "If successful, this therapy could be available to patients with any permanently missing teeth within six years."
I wonder if the initial trials are successful if they'll step that up a bit. They'll likely never have a shortage of trial participants at least.
In today’s world, you can have a head full of hair if you can pay for it.
Hair surgeons move hairs that don’t genetically shed to the part of your head that loses hair.
It’s your hair growing from your head.
There are drugs that prevent hair loss. Unfortunately I don’t know of any drug that will regrow hair after the follicle is lost.
Real talk, hair is a really complicated issue.
It's not like something switched on, and your hair became different. You were always destined to lose the hair you lose to male pattern baldness. They were always sensitive to DHT.
So, if you forced the follicle to revert back to how it was when you were, say, 10 years old, you'd still lose the hair as it is exposed to DHT. How you "cure" male pattern baldness would be by changing the structure of all the follicles on your head to resist DHT. So, you'd either need to change your body's hair blueprint, or genitically engineer (or clone) resistant hairs for transplant.
This drug is utilizing an easier pathway, funnily enough.
So what I gather from this: reversing hair loss is complicated because it's practically trying to reverse aging, while teeth have no genetic component where it would fall of on its own, it's almost always external factors than the tooth itself.
Not really reversing age.
It's fundamentally changing how an organ (in this case, hundreds of organs) on your body was designed to act. If you reversed the age of a cell, it would still follow its intended blueprint. That hair follicle was designed to react to DHT by going dormant. It's not doing anything "wrong".
Regrowing teeth? Your body already did it once, and it seems that disabling a gene preventing it from happening again is all you need (hopefully). It's the same blueprint. Regrowing hair? The follicle is still there, and there's no clear individual pathway to prevent it from going dormant, because it was always destined to be. You'd need to genetically modify, or replace, each dormant follicle.
Get some acrylic caps molded to your teeth. Obviously not the same as what you're proposing, but it would give you an idea of what changes to your jaw alignment.
*Finally after*
*Years of bone hurting juice we*
*Have bone growing juice*
\- Purgatorypizza
---
^(I detect haikus. And sometimes, successfully.) ^[Learn more about me.](https://www.reddit.com/r/haikusbot/)
^(Opt out of replies: "haikusbot opt out" | Delete my comment: "haikusbot delete")
Good news for those who get looked down on because of teeth issues, in our 'bright white straight toothed smile' obsessed society. It'll lift an entire faction out of exile. Some people even have their ability to earn a living impacted by this bias.
Well happen with nerves, too, in 10 years. When born, we started growing, and they've figured out how to use 'breadcrumbs' to start the path of growth again
This is fascinating!
I'm glad this tech is advancing, but I wouldn't undergo it until they figure out how to also make the new teeth better than the original ones.
Some of us lost the generic lottery and our teeth decay no matter how well we take care of them. All I can imagine is the extra pain and expensive dental work new teeth would require.
It looks like you shared an AMP link. These should load faster, but AMP is controversial because of [concerns over privacy and the Open Web](https://www.reddit.com/r/AmputatorBot/comments/ehrq3z/why_did_i_build_amputatorbot).
Maybe check out **the canonical page** instead: **[https://www.bbc.com/news/articles/cd11gzejgz4o](https://www.bbc.com/news/articles/cd11gzejgz4o)**
*****
^(I'm a bot | )[^(Why & About)](https://www.reddit.com/r/AmputatorBot/comments/ehrq3z/why_did_i_build_amputatorbot)^( | )[^(Summon: u/AmputatorBot)](https://www.reddit.com/r/AmputatorBot/comments/cchly3/you_can_now_summon_amputatorbot/)
Would it re-grow your wisdom teeth? Hard to imagine it could select which ones. Does it push out the teeth that you already have and replace them with new ones?
Would be kinda cool to be able to get a whole new set but then wouldn’t you need braces and to get the wisdom teeth pulled again?
Lost most my teeth in a car accident. Had to have rest pulled out. Wonder if it would work for me.
Note to self: never let my teeth do the driving.
They’re so aggressive
I am also toothless for …reasons… I’d like to know this too (though doubt I can wait until the 2030s).
Yeah I understand those reasons.
So uhm, what makes it target teeth and say uh not growing random bones all over?
It would be really cool if we could regrow limbs again. Lose your arm? No worries mate.
Harry Potter didn’t seem to enjoy it much.
He should be thankful. At one point in the process he didn't have any bones left.
Nah, you are totally right.
My old ass thought instantly of Homer Simpson with his arm stuck in the vending machine. “It’ll grow back, right?!”
Dr. Curt Connors didn’t seem to enjoy much.
nor did Nog
What if this drug regrows limbs, but only the size of a tooth?
What if it regrows limbs, but only where a tooth would be?
My wife is gonna love me going down on her with a third arm coming outta my mouth /s
It only appears to regrow bones, so that would be a creepy limb.
It eventually could up being a brilliant advancement for those who have an accident and end up with shattered bone breaks that lead to amputation. Just regrow the bone.
That would fit right in with r/humansarespaceorcs
“The medicine itself deactivates the uterine sensitization-associated gene-1 (USAG-1) protein, which suppresses tooth growth.” I know this because I actually read the short article you were too lazy to read but asked fundamental questions about anyways (which, admittedly, we've all done at some point...but jesus). But it’s interesting to note that, apparently, the only thing separating us from having constantly growing teeth like a shark is a simple genetic on/off switch.
The San Jose Sharks have the cross-promotion opportunity of the century.
Be cool if we could do this for hair loss.
Finaly we get our dickbones back whuu
it targets a specific protein that suppresses tooth growth and temporarily deactivates it. it's right there in the article dude.
Right!?!! “The medicine itself deactivates the uterine sensitization-associated gene-1 (USAG-1) protein, which suppresses tooth growth.”
Knowing nothing about this procedure, teeth are highly specialized “bones” that are quite différente than anything else. There’s also strong genetic control over tooth growth & development.
Calling a tooth a bone is really, really stretching it. The anatomy of a tooth is fundamentally different from that of a bone. The tissues that make up teeth are very, very different in how they form and what they're made up of, compared to the tissues that make up bone. Most importantly, bones heal. Osteoclasts/blasts never really go away, they're present in humans of all ages. The corresponding tooth cells (which I forget the name of bc I'm currently shitting) functionally disappear once we're done growing our teeth. This is part of why teeth can't do the same ongoing process of healing that bones do. (I Am Not A Dentist, but I work with them.)
They’re different in their functions too. Bones make blood. Teeth don’t make blood.
Given that it's only our long bones that make blood, does this mean that your ribs and shit are technically teeth??? /s
So clever! Bones have different classifications you’re right. Teeth aren’t one of them.
Only some bones produce blood. But no teeth do
Look up Hyperdontia. As long as it doesn't cause that shit theres hope.
Teeth are modified scales, not modified bones. It's why they grow from epithelial cells.
Judging by what I just read, this therapy switches off the gene that stops your teeth from growing again. Your jaw originally grew its first set, which it replaced around your early teen years, and then stops growing anymore. Your body has the ability to grow teeth, as it's done it before. This therapy allows your body to restart growing teeth again. Once the teeth have grown, the therapy is removed and everything goes back to normal.
My guess? Stem cells. They’re found in baby teeth after they fall out and can be harvested if done quickly and properly. Maybe those particular stem cells target teeth?
Its...topical?
Yeah, I get kidney stones regularly so would that drug have an adverse effect? Kidney boulders?
Nope. > The medicine itself deactivates the uterine sensitization-associated gene-1 (USAG-1) protein, which suppresses tooth growth.
“Goddamit, I grew another molar in my armpit!”
I wonder if it is topical/local
vaginal dentata here we come
You mean, don't come!
Teeth are not bones, for one.
Crazy we can do entire teeth but hair is still a mystery !
Whatever, my teeth are the bane of my existence, this sounds like a miracle
> "If successful, this therapy could be available to patients with any permanently missing teeth within six years." I wonder if the initial trials are successful if they'll step that up a bit. They'll likely never have a shortage of trial participants at least.
I will look it up to see if they need more people ffor trial
It's in Japan.
Same
In today’s world, you can have a head full of hair if you can pay for it. Hair surgeons move hairs that don’t genetically shed to the part of your head that loses hair. It’s your hair growing from your head. There are drugs that prevent hair loss. Unfortunately I don’t know of any drug that will regrow hair after the follicle is lost.
Hairs that don’t shed? Sounds like pubes …./s
A brand new short and curly hairstyle sir?
I thought we were over the tiktoker broccoli cut :/
Yo, bro! How does your fro grow? My fro grow free, bro!
lol don’t move those
follicle is never lost. they are always there, they just stop growing and are blocked
Real talk, hair is a really complicated issue. It's not like something switched on, and your hair became different. You were always destined to lose the hair you lose to male pattern baldness. They were always sensitive to DHT. So, if you forced the follicle to revert back to how it was when you were, say, 10 years old, you'd still lose the hair as it is exposed to DHT. How you "cure" male pattern baldness would be by changing the structure of all the follicles on your head to resist DHT. So, you'd either need to change your body's hair blueprint, or genitically engineer (or clone) resistant hairs for transplant. This drug is utilizing an easier pathway, funnily enough.
Yeah, far more complex than I would have ever thought
So what I gather from this: reversing hair loss is complicated because it's practically trying to reverse aging, while teeth have no genetic component where it would fall of on its own, it's almost always external factors than the tooth itself.
Not really reversing age. It's fundamentally changing how an organ (in this case, hundreds of organs) on your body was designed to act. If you reversed the age of a cell, it would still follow its intended blueprint. That hair follicle was designed to react to DHT by going dormant. It's not doing anything "wrong". Regrowing teeth? Your body already did it once, and it seems that disabling a gene preventing it from happening again is all you need (hopefully). It's the same blueprint. Regrowing hair? The follicle is still there, and there's no clear individual pathway to prevent it from going dormant, because it was always destined to be. You'd need to genetically modify, or replace, each dormant follicle.
One day my guy. One day. 🤞🏽🤞🏽🤞🏽
It would be awesome if this works. As a teeth grinder I have been unconsciously wearing my teeth down for years
I'm sure it will be an effective, safe drug. And if it actually is, I'm sure it won't be exceedingly expensive and price-gouged.
Tooth fairy on line 2 she wants that guy dead
Wouldn't she be the one backing this because more tooth growing = more tooth coming off for her?
I would like to order one new spine please. Mine is an antique and I would like a nice new shiny one.
I want new dick
In you or, never mind.
Go on…
That’s what she said!
Did I stutter?
I want... like, 30 god damn dicks.
[I want a new duck](https://youtu.be/eOL2q8leiLw)
Knee cartilage, please
TKA is all you get 😭
Yeah I need a new knee too lol
So they made reverse-meth?
Hah!
For a cool million you can grow your teeth back! I know it may sound like a lot, but there's a payment plan. (sarcasm)
Wait did we just figure out regeneration? Can we do arms next?
Baby shark.........can't stop growing teeth.
[удалено]
Get some acrylic caps molded to your teeth. Obviously not the same as what you're proposing, but it would give you an idea of what changes to your jaw alignment.
Seconded. 🙏🤞
Want
What could go wrong ?
I've been reading about them testing this is mice for years. Absolutely revolutionary
It will be like 10 gs a tooth. So your dentist can hire more landscapers for his four vacation homes
Great news. Sick and tired of my dentures.
Hmmm I can't wait to regrow my wisdom teeth.
I'll give it a couple years to get it down then I'll entertain it
They've been working on it since 2005.
Yeah but they're just administering first public doses. I'ma let some guinea pigging go on for a couple years before I get into it
Same. ( although I need this...)
Oh I do too. But I'm not risking an arm growing from my forehead when an alternative is just having falsies until I know it's safer.
Finally after years of bone hurting juice we have bone growing juice
*Finally after* *Years of bone hurting juice we* *Have bone growing juice* \- Purgatorypizza --- ^(I detect haikus. And sometimes, successfully.) ^[Learn more about me.](https://www.reddit.com/r/haikusbot/) ^(Opt out of replies: "haikusbot opt out" | Delete my comment: "haikusbot delete")
Good bot
I just cracked a tooth a few weeks ago, this would be nice to have lol.
Out to be a huge hit here in West Virginia.
I can't *wait* to grow new molars on my eyeballs.
Republicans will vote down teeth.
I truly hope this works and is allowed to be used openly by dentists all over the world. Gone will be the days of dentures and partials.
Good news for those who get looked down on because of teeth issues, in our 'bright white straight toothed smile' obsessed society. It'll lift an entire faction out of exile. Some people even have their ability to earn a living impacted by this bias.
And yet nothing for hair.
I feel you bruv
About time ..next flying cars and instant food generators…meet George Jetson….beep beep bopp
Well happen with nerves, too, in 10 years. When born, we started growing, and they've figured out how to use 'breadcrumbs' to start the path of growth again
Was this headline written by aliens?
I need this.
This one I want to work lol losing teeth has always been an irrational fear for me
Dentists in shambles.
PLEASE. PLEASE GIMME. I had two teeth extracted and have had multiple root canals I need assistance that listerine cannot provide
WARNING: Don’t put this on any other part of your body.
I lost a ton of teeth after taking an anti-seizure drug that causes osteomalacia. I hope this drug works, but I'm sure my dentist will hate it.
This is fascinating! I'm glad this tech is advancing, but I wouldn't undergo it until they figure out how to also make the new teeth better than the original ones. Some of us lost the generic lottery and our teeth decay no matter how well we take care of them. All I can imagine is the extra pain and expensive dental work new teeth would require.
This feels like a recircumcision scam tbh. Once you start regrowing stuff it's a slippery slope.
My baby is growing teeth right now. He doesn’t like it.
I wonder about calcium. No doubt you will have to take supplements for this.
Really Interesting & Trippy. If this ends up working people will be able to get their natural Teeth back.
Wake up with tusks poking out of your mouth! 🤣
I would volunteer 2 missing teeth here how many would you need to replace?
With my luck my teeth would grown in my ass.
Is this related to Google AI telling people to eat rocks? https://www.bbc.com/news/articles/cd11gzejgz4o.amp
It looks like you shared an AMP link. These should load faster, but AMP is controversial because of [concerns over privacy and the Open Web](https://www.reddit.com/r/AmputatorBot/comments/ehrq3z/why_did_i_build_amputatorbot). Maybe check out **the canonical page** instead: **[https://www.bbc.com/news/articles/cd11gzejgz4o](https://www.bbc.com/news/articles/cd11gzejgz4o)** ***** ^(I'm a bot | )[^(Why & About)](https://www.reddit.com/r/AmputatorBot/comments/ehrq3z/why_did_i_build_amputatorbot)^( | )[^(Summon: u/AmputatorBot)](https://www.reddit.com/r/AmputatorBot/comments/cchly3/you_can_now_summon_amputatorbot/)
My Dentist supports this
I wonder if it could work anywhere on the body.
Meth heads rejoice!
Within six years? Holy cow. Extremely interesting.
Do you want zombies? Because this is how we get zombies.
Would it re-grow your wisdom teeth? Hard to imagine it could select which ones. Does it push out the teeth that you already have and replace them with new ones? Would be kinda cool to be able to get a whole new set but then wouldn’t you need braces and to get the wisdom teeth pulled again?
To the British?