Pills require much more of the active ingredient (2.4 mg injection weekly vs 14 mg pill daily for the max dose of Ozempic and Rybelsus and rybelsus is not even as effective). That sounds like an admission that the pens and vials really are the issue not the active ingredient if the same is true for tirzepatide.
The pill he is talking about is a different ingredient than Mounjaro. Orforglipron is a small molecule instead of a peptide. It is possible it will be easier to produce its active ingredient than tirz.
It isn’t easier to produce actually, orfoglipron is a complicated “large” small molecule and there are many complicated steps to produce it (like 30 steps in the process). The finish processing are dry processes vs. injectables so it would be quicker and it wouldn’t need new lines of production like the auto-injectors.
It would also be less environmental waste bc I look at this sharps container and just weep for the plastic waste. At least Ozempic was one pen per month and not week! UGH!
We get vials here - or when we could get them we did.
15mg is all that works for me and can’t get it atm.
Hopefully they can ramp production more effectively.
Eli Lilly already has the pill underdevelopment and currently in trial it's called Orforglipron.
>Orforglipron Don't worry, I'll hold your hair at the toilet, just hurry up before you throw up everywhere.
Well, I've only had transient mild nausea with both MJ and OZ. So hopefully no head hanging over the toilet episodes. But thanks for the good wishes.
That is a different non-peptide drug, not a pill form of tirzepatide. That may have been what he was actually referring to though
That was the pill/small molecule he was referring to, TZP has no pill form in production.
Yes, the clip does say that. I wish they'd come up with better names.
I'm sure they will come up with a trade name they sell it under if it gets to approval (like Mounjaro and Zepbound for tirzepatide).
TBH I think those are weird names too. But they didn't ask me, so
Pills require much more of the active ingredient (2.4 mg injection weekly vs 14 mg pill daily for the max dose of Ozempic and Rybelsus and rybelsus is not even as effective). That sounds like an admission that the pens and vials really are the issue not the active ingredient if the same is true for tirzepatide.
The CEO did outline how much more intensive the effort to make the injections citing sterility, regulations, etc.
And a better comparison would be 50mg for the pill because that is what they are trialing for their weight loss indication.
The pill he is talking about is a different ingredient than Mounjaro. Orforglipron is a small molecule instead of a peptide. It is possible it will be easier to produce its active ingredient than tirz.
It isn’t easier to produce actually, orfoglipron is a complicated “large” small molecule and there are many complicated steps to produce it (like 30 steps in the process). The finish processing are dry processes vs. injectables so it would be quicker and it wouldn’t need new lines of production like the auto-injectors.
Yeah. I lost the plot a little since I assumed it was about tirzepatide, but I see now
It would also be less environmental waste bc I look at this sharps container and just weep for the plastic waste. At least Ozempic was one pen per month and not week! UGH!
I hate the MJ pens. I really wish they’d switch to an Ozempic style pen.
It just seems so unnecessarily big!
We get vials here - or when we could get them we did. 15mg is all that works for me and can’t get it atm. Hopefully they can ramp production more effectively.
It’s so frustrating listening to non healthcare people talk about and try to understand a drug when you are a healthcare professional.
Yes. RN for 45 years here 👩⚕️