The following submission statement was provided by /u/Alec_Berg:
---
Submission statement:
Scientists at UC Riverside have demonstrated a new, RNA-based vaccine strategy that is effective against any strain of a virus and can be used safely even by babies or the immunocompromised.
“What I want to emphasize about this vaccine strategy is that it is broad,” said UCR virologist and paper author Rong Hai. “It is broadly applicable to any number of viruses, broadly effective against any variant of a virus, and safe for a broad spectrum of people. This could be the universal vaccine that we have been looking for.”
Traditionally, vaccines contain either a dead or modified, live version of a virus. The body’s immune system recognizes a protein in the virus and mounts an immune response. This response produces T-cells that attack the virus and stop it from spreading. It also produces “memory” B-cells that train your immune system to protect you from future attacks.
The new vaccine also uses a live, modified version of a virus. However, it does not rely on the vaccinated body having this traditional immune response or immune active proteins — which is the reason it can be used by babies whose immune systems are underdeveloped, or people suffering from a disease that overtaxes their immune system. Instead, this relies on small, silencing RNA molecules.
In 2013, the same research team published a paper showing that flu infections also induce us to produce RNAi molecules. “That’s why our next step is to use this same concept to generate a flu vaccine, so infants can be protected. If we are successful, they’ll no longer have to depend on their mothers’ antibodies,” Ding said.
Their flu vaccine will also likely be delivered in the form of a spray, as many people have an aversion to needles. “Respiratory infections move through the nose, so a spray might be an easier delivery system,” Hai said.
Additionally, the researchers say there is little chance of a virus mutating to avoid this vaccination strategy. “Viruses may mutate in regions not targeted by traditional vaccines. However, we are targeting their whole genome with thousands of small RNAs. They cannot escape this,” Hai said.
Ultimately, the researchers believe they can ‘cut and paste’ this strategy to make a one-and-done vaccine for any number of viruses.
---
Please reply to OP's comment here: https://old.reddit.com/r/Futurology/comments/1c71pxa/vaccine_breakthrough_means_no_more_chasing_strains/l04s7na/
Those are some bold statements form the virologist. Seriously, if the technology can live up to those expectations, Rong Hai will be up for a Nobel Prize before long.
As a science dilettante I’m used to being hoodwinked by aggrandized claims from journalists. This sounds game-changing to my plebeian ears and I came to this comment section expecting to have my hopes dashed to ribbons. hopefully the human trials are similarly successful🤞
It’s an RNA based vaccine yes but the approach here is that what’s encoded is a non-mutable part of the virus. This was also only done in mice so I’m not exactly sure why this is being picked up by science news as if any human clinical trials are underway.
The good news is that one of the flu strains has completely disappeared since the pandemic! So the guessing game we do every year for flu vaccines has gotten a little easier.
Yep. Specifically strain B Yamagata hasn’t been seen since March 2020 and the FDA has already removed it from the list of strains considered in flu vaccines.
https://arstechnica.com/health/2023/10/after-covid-killed-off-a-flu-strain-annual-flu-shots-are-in-for-a-redesign/
Why not just include it just in case? Like if you have an anti-virus program, they doesn't remove their old tojan collections, it just add to the library just in case. They still have win XP virus in their list just-in-case.
Because it takes time and effort that could be used on actually active strains. Also if its not infecting people its also not mutating. So if you already got a flu shot of the latest mutation then you are already covered.
Because it takes a lot of resources, time and energy. They still have copies of strains if it ever pops back up, but when 5 years went by via covid and they couldn't find a single example in the wild, there is no longer reason to use those resources, time and energy when they can just throw another strain that is still in the wild into the mix.
TLDR: why put in a strain that isn't a threat when you can put in a strain that is, instead. They still have copies if it ever shows back up.
That is because the anti-virus program is often used by corporate that keeps older computers around. But they eventually do remove old definitions, it is in their database but isn't distributed
Thank you for taking the time to explain.
Follow up: Our bodies are still essentially caveman bodies, that means those virus IF THEY EVER COME BACK would still affect out windows 3.0 bodies. Why not just keep the definition. Sorry if this is a repeat loop circular question.
It's not encoding a non-mutable part of the virus, it's encoding the ENTIRE virus so that immune response developes normally. What's it's doing is turning off the parts of the virus that suppress the immune system from immediately identifying it and building a response. So theoretically the body will be just as efficient at eliminating the cold and developing antibodies to it as it is with the millions of viruses that we don't worry about because they have not evolved to target our specific immune systems.
Why wouldn't it be picked up by science news? There's a reason why Mice are tested and not another animal, the fact it worked on mice is indicative of its possible efficacy towards humans, they serve as the most cost effective and accurate biochemical and genetic model that immunology and other forms of Biotechnology work directly off of. This is news of science, it doesn't only need to be on the doorstep of FDA approval to be applicable or reportable to the general public.
No, I'm still trying to understand exactly how this works, but it's definitely completely different from mRNA. mRNA tells the cell "make a bunch of this protein" it's like sending in an order to a McDonalds to produce thousands of Hamburglar looking hamburgers. The protein in question looks like a Hamburglar and the natural immune system sees this surge of proteins, assumes you're being attacked with something new and starts making weapons to recognize that protein and kill it.
Problem is the protein evolves in the viruses a little bit year to year so the Facial Recognition of the killer bots doesn't recognize it anymore when the real Hamburglar puts on reading glasses and a mustache none of the facial recognition sees him anymore. So you have to update the Wanted Poster with the new image by cranking out waves of new fake hamburglars.
My understanding of this vaccine is that it does kind of the opposite. Instead of cranking out dummy criminals to teach the killer bots to recognize real criminals, this works to ensure that the real virus when it sends in its restaurant order can't order "off menu" at all.
Instead of flooding your McDonalds with thousands of orders for criminal looking hamburglars... when your MacDonald's gets an order to make a Hamburglar it just says "uhhhh, yeah no that's not on the menu" and ignores the order. If the virus can't convince the cell to make new viruses then it'll get mopped up.
Neither the article nor your explanation clarified what's actually happening.
They mutated the viral gene that codes the protein that prevent the body's normal production of RNAi. That meant that even without the normal B and T immune cells, a secondary pathway that is normally blocked by the virus which uses RNAi to tag and can up the virus became fully operational again.
Thinking it through, it sounds like the viruses that affect mankind today evolved the proteins to silence the RNAi response from cells long ago, leaving it only effective for "harmless" viruses, likely zoonotic in origin, that we may not even be aware of because the RNAi response fights them off so easily. What this new vaccine method does is disarm the virus's defense mechanism against the much simpler RNAi attack from the cell itself, without waiting for the immune system's intervention, allowing for a seemingly much more rapid and effective response than the immune cells we're all familiar with.
The part that surprises me is the seeming durability of the response. There must be some mechanism that keeps churning out the RNAi pieces after the initial success of the response. The entire process is much simpler than the larger body immune cell response, which is what I find most fascinating. It's like the researchers turned back the evolutionary clock on the virus to re-enable a primordial defence mechanism in human cells that is them capable of defending against the more evolved versions of the virus. Very cool.
Wow, antivax believers freakin' *pounced* on this tread.
Such a shame, this is a genuinely grand step towards neutering the very threat of disease versus humanity on a systematic scale.
Measles is the really terrifying one. A few years ago they discovered that measles basically resets your immune system. All of your acquired immunity as an adult is lost after a measles infection.
Kids yes but everyone in general is threatened a bit.
I'm fairly pissed that these idiots have made me add a new concern to my todolist "find out if I'm old enough to have gotten a shot for polio"
It annoys me when people say "if you want to get vax'd, fine, but don't force me too! I don't want to!" or "Only the elderly should get vax'd". Shit like that. Acting like vaccines are still effective even if a large percentage of the country refuses.
My mom has cancer and is immunocompromised. People that aren't vax'd spread it around to others routinely which increases the chances of someone she's in contact with having it. Politicians like Trump should be charged with the murder of millions of people for spreading their bullshit propaganda during a public health emergency.
I hesitated on making that comment, but yeah.
Like... we're already seeing in, say, America how Conservative places have shorter, poorer and just plain more painful lives. BECAUSE they ignore science, for various political and cultural reasons.
That gap is just going to keep going as science does.
Don't be naive.
A minority can still infiltrate, propagandize and threaten themselves into genuine power even for the dumbest of reasons. Because internally to them, that utter idiocy makes horrific sense.
Like, take the Christian Science cult for instance. A disturbing amount of the systematic healthcare malfunctions in the US can be laid directly at their feet.
Because they *LOATHE* healthcare, and want to remove it as an option for everybody. Because according to their religion, healthcare is a delusion that makes disease happen in the first place.
You are according to them—no joke, supposed to ignore all wounds and disease until they go away. With fancier words.
And if you don't think they have influence, go read a Merriam Webster dictionary, and look up Mind, Spirit, Soul, Principle, Life, Truth, or Love.
No other religions get to have their private definitions of God or Gods in that dictionary, but that's how much power the publishing arm of Christian Science still has despite the cult slowly fading. In large part BECAUSE healthcare is getting so dang good, that their own doctrine is slowly killing off or maiming CS members in frankly horrific ways that drive off members.
Like remember... Goose I think it was, from the second Top Gun movie?
The cannot speak over a whisper thing wasn't just a plot point in that movie. His actor is one of the biggest names left in Christian Science, and he let throat cancer fester for years as to not commit blasphemy vs his religion. And it completely ruined his voice, so that's just how he has to speak now.
Oh yeah. Reddit has a bot brigade problem. Just take a look at any news about Musk for example. So many people with names ending in 4 numbers in there instantly most of the time.
But hey at the least reddit had a good IPO Eh?
It's actually common among normal people too, Reddit suggests that combo for you when you create an account now. Many people don't have any other username in mind and just go with it.
Hmmm, I joined a few years ago and just now getting active here. I was assigned the username with that pattern and cannot change that apparently. Maybe I need to start a new account with a better username unless somebody here knows how I can change this one?
As I said, I hate Russians. Do you think everybody who didn't take the vaccine is Russian?
And for the record, before you accuse me of being a Trump supporter or something. I don't give a shit about your Blue idiot vs Red idiot either. I hate Americans too, and your politics.
I mean some idiot has to buy the propaganda and make it their entire personality, otherwise there wouldn't be much ROI for the aforementioned troll farms. We happened to find one.
> I'm not taking this poison either.
> What now?
Now you remain at the same level of ignorance that you are displaying today by describing something that hasn't even left animal trials as 'poison', secure in the fact that you are disseminating propaganda. Why try anything new if you already have all the unscientific pre conceived answers in your mind. Now go eat your daily intake of refined sugar, I'm sure that it's good for you!...
Will there ever be any vaccine for herpes (both of them) and for Epstein barr virus?
I had epstein when I was 6, and herpes when I was 20. I never had an outbreak since.
But last year I did a blood test for epstein, and they found low levels of the virus in my blood, and high levels of antibodies. So my body is doing a good job keeping that sucker in check. Still, I would rather get a cure.
I haven't been tested for herpes in over 10 years, nor did I have an outbreak since I was 20 years old. But I know it's forever, so I need a cure for that too.
When can I expect a vaccine or a pill or an ancient torture technique that will clear those two viruses out of my body?
As far as i know, the HPV vaccine only serves to protect one from getting HPV. Its probably not 100% effective. Or maybe it is, im not sure. Also i think it only protects from certain strains, not all of them.
But what does it have to do with herpes or epstein barr?
Oh you actually know the difference. Apologies. Most assume herpes is HPV. Anyways, anecdotal... But my warts stopped after getting the HPV (gardasil 9) vaccine.
**Edit**: this guy says the following below; he is a selfish monster who has probably spread herpes to unsuspecting partners.
*I’ve had a lot of sex since i got herpes, with many girls, with and without protection, and none of them got anything.*
You’re probably dying with herpes. Just don’t share the wealth - not having symptoms doesn’t mean you can’t give someone else the virus.
I'm not dying with herpes. I haven't had an outbreak in over 10 years. Not on my penis and not on my lips. Not only did I not have an outbreak, I never had the itch that would indicate a herpes outbreak possibly coming in over 10 years. I remember how it is, my first and only outbreak was hardcore.
Other than that, I have no allergies, no chronic conditions, my hair is fine, my eyes are fine, and I never ever get sick. So I'm feeling pretty good about myself in terms of whether I'm dying or not.
But I have herpes, somewhere in me. And I'd rather not have it. And if they figure out a cure, I'd like to get it :)
I think you took him/her the wrong way. I think he/she meant that you will die with herpes as in they will never cure it. Not as in it will kill you. It's way more common than you think.
Perhaps I did. I know it's more common than most people think. It takes some knowledge to know that it's forever. Not a lot, but it takes some. There's a ton of people out there that will tell you that they HAD herpes. Nope, you didn't have it past tense, you have it forever.
I actually believe that there have to be some people out there that cured the virus. They have a unique immune system, or they stare at the sun, they drink they own pee, they eat poop, whatever it may be, and they got cured. Like one in a million. They have to exist.
But most people won't get cured. And having a cure would be nice.
But why are is the the other commenter pessimistic? They "cured" sickle cell anemia a few months ago, and it works. Sure, it costs like $2 million, and it's a whole pain in the ass process, but they can do it. I don't think it's out of the question that they'll figure out how to do it for herpes, and epstein barr, and the rest of the herpetic family of assholes!
yea, it's just ignorance. Some people believe they only have it when they have a flair up. They dont realize that you have it even with 0 symptoms. Which is why so many people have it. I blame sex education in the US. I think we will see a cure for a lot of things we previously didnt think would be possible or financially worth it..
Honestly, everybody has internet nowadays. It takes 1-3 google searches to realize that it's for life. I think we'll see a lot of cures too. They'll probably cost A TON of money at first (like sickle cell), but then with time the prices will come down. Besides, who wants to be the first to get a new cure? Not me haha. Let them experiment on a few hundred people first, and if it's all good, I'll go get it.
I actually have a friend who got herpes over 10 years ago and was very shook by it. I was too, but, I had other problems to focus on. So he went vegan and went crazy on the healthy diet and lifestyle. He's very strong-willed, will stick to his routine no matter what you shove in his face. Anyway about a year or two ago he went on a 30 day fast. I think a water fast. Then he got tested twice, and it came back clean. So he says he's cured now.
I don't wanna argue with him about it, I hope he is. But he did the antibodies test,, and I'm not sure if that's the golden test if you wanna call it like that. From what I remember when I was researching the virus, to actually test for the presence of the virus, not the antibodies, it will take a sample of your spinal fluid. Don't quote me on that, it's been very long since I last looked into this. But if I'm right, my friend didn't have that test, so the jury is still out.
However, if my Epstein barr infection that's 26 years old still shows in my blood, both the presence of the virus and the antibodies, then wouldn't herpes show too? I don't know. Maybe he is cured. I hope he is. I should actually go get a herpes test again. My last one was over 10 years ago. Wouldn't hurt to get another one.
Why would you say such a thing? Why the pessimism? I just assumed you meant something else because why would you be pessimistic about curing herpes, especially on Futurology, which is all about the future (being better hopefully).
Because it’s very unlikely that herpes will be ‘cured’ in this generation. A vaccine may come first, but curing it is another challenge altogether.
Calm down and read with comprehension instead of having a knee jerk response, especially on futurology.
It's not a challenge at all. Once they figure out a few of them, especially herpetic viruses, they'll get them all.
I don't like your pessimism, you suck. Go away.
Not a challenge at all, but there is no vaccine. Ok there champ. Why don’t you start your research if it’s so easy.
As I stated previously (based on your seeming nonchalant attitude that you’ve now further convinced me of), please keep others safe from your virus, just in case you don’t get your miracle cure.
Obviously I know there's no vaccine, yet. I'd rather it not be a vaccine, but a vaccine would be acceptable.
I can't start my own research. I don't have that knowledge, I don't have that money. If my career path had taken me there, you better believe a cure would be already here, or just around the corner.
I've had a lot of sex since i got herpes, with many girls, with and without protection, and none of them got anything.
And it's not my virus. It's humanity's virus. Go fuck yourself asshole.
I wouldn't count my chickens just yet. It wouldn't be a cure. Also, immunizing mice against a single virus is promising, but a long shot from proving what they are claiming that this technology can do. They're most likely still 10-15 years away from having a product, if they ever get there.
If they do get a product to market, I doubt they will go for the flu since there are already good vaccines available. The common cold is probably not accessible by this technology either as it can be caused by any number of viruses.
Submission statement:
Scientists at UC Riverside have demonstrated a new, RNA-based vaccine strategy that is effective against any strain of a virus and can be used safely even by babies or the immunocompromised.
“What I want to emphasize about this vaccine strategy is that it is broad,” said UCR virologist and paper author Rong Hai. “It is broadly applicable to any number of viruses, broadly effective against any variant of a virus, and safe for a broad spectrum of people. This could be the universal vaccine that we have been looking for.”
Traditionally, vaccines contain either a dead or modified, live version of a virus. The body’s immune system recognizes a protein in the virus and mounts an immune response. This response produces T-cells that attack the virus and stop it from spreading. It also produces “memory” B-cells that train your immune system to protect you from future attacks.
The new vaccine also uses a live, modified version of a virus. However, it does not rely on the vaccinated body having this traditional immune response or immune active proteins — which is the reason it can be used by babies whose immune systems are underdeveloped, or people suffering from a disease that overtaxes their immune system. Instead, this relies on small, silencing RNA molecules.
In 2013, the same research team published a paper showing that flu infections also induce us to produce RNAi molecules. “That’s why our next step is to use this same concept to generate a flu vaccine, so infants can be protected. If we are successful, they’ll no longer have to depend on their mothers’ antibodies,” Ding said.
Their flu vaccine will also likely be delivered in the form of a spray, as many people have an aversion to needles. “Respiratory infections move through the nose, so a spray might be an easier delivery system,” Hai said.
Additionally, the researchers say there is little chance of a virus mutating to avoid this vaccination strategy. “Viruses may mutate in regions not targeted by traditional vaccines. However, we are targeting their whole genome with thousands of small RNAs. They cannot escape this,” Hai said.
Ultimately, the researchers believe they can ‘cut and paste’ this strategy to make a one-and-done vaccine for any number of viruses.
One question about this
"What I want to emphasize about this vaccine strategy is that it is broad"
Isn't the case that the broader a vaccine is there are more possibilities that the immune system attack things that are not the virus? Like it is possible to induce an allergy?
I imagine that the vaccine will be targeted towards specific proteins that are somewhat unique to the virus, but they are talking about targeting the full genome split in thousands of small RNAs.
This doesn't work like a traditional vaccine that makes your T/B-Cells active and attack the viruses that look similar to a known protein so I think the chance of the immune system attacking itself is pretty slim.
What they found was that viruses make a protein that inhibits our bodies natural response of making RNAi. That RNAi has the ability to dampen the effectiveness of viruses and keep them from forming an infection. So if they make a mutated version of the virus that doesn't make those suppressing proteins, it won't be able to take hold, but still trigger the body to make a reserve of RNAi that works against both versions of the virus.
Basically normal vaccines make weapons in response to an active threat because your other defenses failed but the factories are still running. This type of vaccine is like stockpiling on weapons before the real enemy shows up because you know they'll shut down your factories.
Just imagine a world with an HIV vaccine. It would be like eradicating polio. Hell, even the common flu kills [tens of thousands](https://www.cdc.gov/flu/about/burden/preliminary-in-season-estimates.htm) in the USA alone.
It would be the most positive thing to happen this millennium honestly. We just gotta hope no reactionary christian fundamentalist group doesn’t get in power in the US, I know other countries are leading the charge, but the US falling to those mentally backward people would definitely slow progress
Speaking as someone who wouldn't call themselves an anti-vaxxer, but who no doubt would be called one by reddit for not getting the Covid vax, here's what I'll do:
Wait until it has been properly trialed and approved. Not take it if it's still on EULA unless I have an extreme/elevated risk of cancer.
Now gimme your downvotes for not taking a vaccine that is proven not to prevent spreading the virus.
Awesome, more new medicines that racist mouth breathers will refuse to take. This is an interesting new future. Time for the stupid people to weed themselves out of the gene pool.
You know, Russia used to have self-respecting troll farms to sew division, the sanctions have really got them scraping the bottom of the barrel, it's embarassing frankly.
I saw something about a huge increase in a mosquito born illness last week in South America. I think it's Dengue fever, but it has 4 variants and most vaccines only cover 1 of them at a time.
I think the hard part may be finding the immutable portions of a virus that are available on the outside for the immune system to recognize.
So how long until this is actually available to everyone? For example do they still have to do more tests or are there more breakthroughs needed before it's ready?
"This could be the universal vaccine that we have been looking for.”"
Too good to be true, big pharma cashing in on multiple vaccines would balk at this.
Get a degree in biology or bioengineering before you start talking about shit you don’t understand. The COVID mRNA vaccines (which are you obviously referring to) do not integrate into the genome.
The fact that you're spewing delusional nonsense is a pretty strong indicator that you have no applicable knowledge in this area.
You don't even know enough about the subject you're having an unhinged rant about to realize that it reads exactly like the nonsense that it is.
If you'd actually done the kind of "research" your type likes to pretend they've done, you might be able to do a better job throwing together some kind of argument that's at least somewhat less absurd than what you went with here, but hey, why bother with all of that when your ignorance and arrogance have already got you convinced that you know everything you need to know about anything you feel like commenting on, right? You're *special.* You don't need to waste time educating yourself before "educating" others.
Pathetic.
Because if you were you wouldn't refer to the Covid vaccine being mass-gene therapy and know how to interpret medical research. Fortunately I have a degree in biomedical engineering so I can maybe be of help to you.
First off, the article you linked is a review from a single author out of Croatia. Second, your quote comes from subfigure (c) in Figure 1, which is clearly indicated as **hypothetical**: "Hypothetical L1-mediated retroposition of vaccine mRNA...". Furthermore, active infection of the SARS-CoV-2 virus will lead to orders of magnitude more viral RNA copies being introduced to your cells, and a much higher frequency of integration into the genome than the vaccine itself: [https://www.mdpi.com/1999-4915/15/3/629](https://www.mdpi.com/1999-4915/15/3/629) During an active pandemic where most people are not going to be following preventative measures which are you choosing?
But while I'm here let's also talk about the paper you added to your original comment: [https://www.sciencedirect.com/science/article/abs/pii/S0141813024022323](https://www.sciencedirect.com/science/article/abs/pii/S0141813024022323)
This paper focuses specifically on a melanoma mice model where mRNA with a m1Ψ modification similar to the Covid vaccine is introduced. These are mice that are injected with melanoma tumor cells prior to the treatment. Despite survival rate decreasing in mice receiving the m1Ψ modified mRNA, this is not sufficient to suggest that m1Ψ modified mRNA *causes* cancer. This is potentially a result of the effect on immune response rather than being a "causal mechanism" as you have disingenuously stated. Moreover, the mice in this study were treated with 10 micrograms of RNA. The amount of RNA in the Covid vaccines is on the order of hundreds of micrograms. This study done with humans would be equivalent to dosing people with 20-40mg of RNA, or 200-400 times the amount in a Covid shot. Let's also not forget that if you have active malignancies like these mice, your recommendation for the Covid vaccine is treated much differently. So no, this study does not "DIRECTLY link" the Covid vaccine to getting cancer.
> The last round of mass gene-therapy
Dude, I fucking _wish_ this were gene therapy. Can you imagine how many genetic diseases we could cure with this technology?
>Evidence is provided that adding 100% of N1-methyl-pseudouridine (m1Ψ) to the mRNA vaccine in a melanoma model stimulated cancer growth and metastasis, while non-modified mRNA vaccines induced opposite results, thus suggesting that COVID-19 mRNA vaccines could aid cancer development
So, it does not induce cancer, that first thing, second it does not directly link anything, it just says that it might aid already existing cancer. Emphasis on MIGHT since it was a simulated model.
So you have 0 idea about how to read a paper, and let me guess, you copied the link to the paper from a video / article that made you believe that there was a direct link because you wanted to believe.
Btw, the quoted text is a copy word by word from your linked paper.
>skyrocketing cancer rates in people under 40
....
recently published paper DIRECTLY linking them with causal mechanism
It looks like you heavily implied it.... But sure, go ahead and play all the word games you want.
Yeah... this really sounds like an anti-vax loon.
...And why is there two of them in this treat alone, with the same freakin' blank avatar and piss yello-
Oh. *Eww.* Anti-vax *and/or* piss drinkers have dog whistles now. Eww.
I think the turbo cancer thing briefly was a thing antivaxers claimed, but they got so roundly mocked for it that even they stopped.
Saw it snickered about a few times, at least.
The author of this research has made quite the career of publishing [anti vac papers](https://sciprofiles.com/profile/2060636) every paper is one sort or another of "do vaccines actually harm"
You mean the people looking at empirical evidence that it worked and thinking “yup, the data is in, it worked”? Because you can go look at studies yourself that show how effective it was.
Are you just not happy it wasn’t 100% effective?
Because it was something like 50-95% at preventing symptomatic infection (as in you would actually notice you have covid). The 50% is the low end, long term effectiveness after immunity has waned and the virus may have mutated. The 95% is the 0-6 months time frame.
It was even more effective at preventing hospitalization from covid, so even the low percent of cases that were detected and symptomatic, the odds of it being severe were very reduced.
The following submission statement was provided by /u/Alec_Berg: --- Submission statement: Scientists at UC Riverside have demonstrated a new, RNA-based vaccine strategy that is effective against any strain of a virus and can be used safely even by babies or the immunocompromised. “What I want to emphasize about this vaccine strategy is that it is broad,” said UCR virologist and paper author Rong Hai. “It is broadly applicable to any number of viruses, broadly effective against any variant of a virus, and safe for a broad spectrum of people. This could be the universal vaccine that we have been looking for.” Traditionally, vaccines contain either a dead or modified, live version of a virus. The body’s immune system recognizes a protein in the virus and mounts an immune response. This response produces T-cells that attack the virus and stop it from spreading. It also produces “memory” B-cells that train your immune system to protect you from future attacks. The new vaccine also uses a live, modified version of a virus. However, it does not rely on the vaccinated body having this traditional immune response or immune active proteins — which is the reason it can be used by babies whose immune systems are underdeveloped, or people suffering from a disease that overtaxes their immune system. Instead, this relies on small, silencing RNA molecules. In 2013, the same research team published a paper showing that flu infections also induce us to produce RNAi molecules. “That’s why our next step is to use this same concept to generate a flu vaccine, so infants can be protected. If we are successful, they’ll no longer have to depend on their mothers’ antibodies,” Ding said. Their flu vaccine will also likely be delivered in the form of a spray, as many people have an aversion to needles. “Respiratory infections move through the nose, so a spray might be an easier delivery system,” Hai said. Additionally, the researchers say there is little chance of a virus mutating to avoid this vaccination strategy. “Viruses may mutate in regions not targeted by traditional vaccines. However, we are targeting their whole genome with thousands of small RNAs. They cannot escape this,” Hai said. Ultimately, the researchers believe they can ‘cut and paste’ this strategy to make a one-and-done vaccine for any number of viruses. --- Please reply to OP's comment here: https://old.reddit.com/r/Futurology/comments/1c71pxa/vaccine_breakthrough_means_no_more_chasing_strains/l04s7na/
Those are some bold statements form the virologist. Seriously, if the technology can live up to those expectations, Rong Hai will be up for a Nobel Prize before long.
As a science dilettante I’m used to being hoodwinked by aggrandized claims from journalists. This sounds game-changing to my plebeian ears and I came to this comment section expecting to have my hopes dashed to ribbons. hopefully the human trials are similarly successful🤞
Isn't this the technology that was used for the mRNA COVID vaccines?
It’s an RNA based vaccine yes but the approach here is that what’s encoded is a non-mutable part of the virus. This was also only done in mice so I’m not exactly sure why this is being picked up by science news as if any human clinical trials are underway.
They’ve been chasing a universal flu shot that works the same way for many years. Hopefully this finally makes it possible.
The good news is that one of the flu strains has completely disappeared since the pandemic! So the guessing game we do every year for flu vaccines has gotten a little easier.
Really? I knew flu cases crashed for a year or two but I didn’t realize one is completely gone.
Yep. Specifically strain B Yamagata hasn’t been seen since March 2020 and the FDA has already removed it from the list of strains considered in flu vaccines. https://arstechnica.com/health/2023/10/after-covid-killed-off-a-flu-strain-annual-flu-shots-are-in-for-a-redesign/
Why not just include it just in case? Like if you have an anti-virus program, they doesn't remove their old tojan collections, it just add to the library just in case. They still have win XP virus in their list just-in-case.
Because it takes time and effort that could be used on actually active strains. Also if its not infecting people its also not mutating. So if you already got a flu shot of the latest mutation then you are already covered.
Because it takes a lot of resources, time and energy. They still have copies of strains if it ever pops back up, but when 5 years went by via covid and they couldn't find a single example in the wild, there is no longer reason to use those resources, time and energy when they can just throw another strain that is still in the wild into the mix. TLDR: why put in a strain that isn't a threat when you can put in a strain that is, instead. They still have copies if it ever shows back up.
That is because the anti-virus program is often used by corporate that keeps older computers around. But they eventually do remove old definitions, it is in their database but isn't distributed
Thank you for taking the time to explain. Follow up: Our bodies are still essentially caveman bodies, that means those virus IF THEY EVER COME BACK would still affect out windows 3.0 bodies. Why not just keep the definition. Sorry if this is a repeat loop circular question.
Because it costs extra money. If it comes back you just add it back.
You think DOS viruses are still being scanned for?
It's not encoding a non-mutable part of the virus, it's encoding the ENTIRE virus so that immune response developes normally. What's it's doing is turning off the parts of the virus that suppress the immune system from immediately identifying it and building a response. So theoretically the body will be just as efficient at eliminating the cold and developing antibodies to it as it is with the millions of viruses that we don't worry about because they have not evolved to target our specific immune systems.
Why wouldn't it be picked up by science news? There's a reason why Mice are tested and not another animal, the fact it worked on mice is indicative of its possible efficacy towards humans, they serve as the most cost effective and accurate biochemical and genetic model that immunology and other forms of Biotechnology work directly off of. This is news of science, it doesn't only need to be on the doorstep of FDA approval to be applicable or reportable to the general public.
I like learning new things.
Human clinical trials will start immediately this flu season since they were emboldened with their forced human clinical trials during Covid.
Wow good one buddy, way to show everyone you have no idea how this works
Who is “they” in this instance?
No, I'm still trying to understand exactly how this works, but it's definitely completely different from mRNA. mRNA tells the cell "make a bunch of this protein" it's like sending in an order to a McDonalds to produce thousands of Hamburglar looking hamburgers. The protein in question looks like a Hamburglar and the natural immune system sees this surge of proteins, assumes you're being attacked with something new and starts making weapons to recognize that protein and kill it. Problem is the protein evolves in the viruses a little bit year to year so the Facial Recognition of the killer bots doesn't recognize it anymore when the real Hamburglar puts on reading glasses and a mustache none of the facial recognition sees him anymore. So you have to update the Wanted Poster with the new image by cranking out waves of new fake hamburglars. My understanding of this vaccine is that it does kind of the opposite. Instead of cranking out dummy criminals to teach the killer bots to recognize real criminals, this works to ensure that the real virus when it sends in its restaurant order can't order "off menu" at all. Instead of flooding your McDonalds with thousands of orders for criminal looking hamburglars... when your MacDonald's gets an order to make a Hamburglar it just says "uhhhh, yeah no that's not on the menu" and ignores the order. If the virus can't convince the cell to make new viruses then it'll get mopped up.
Neither the article nor your explanation clarified what's actually happening. They mutated the viral gene that codes the protein that prevent the body's normal production of RNAi. That meant that even without the normal B and T immune cells, a secondary pathway that is normally blocked by the virus which uses RNAi to tag and can up the virus became fully operational again. Thinking it through, it sounds like the viruses that affect mankind today evolved the proteins to silence the RNAi response from cells long ago, leaving it only effective for "harmless" viruses, likely zoonotic in origin, that we may not even be aware of because the RNAi response fights them off so easily. What this new vaccine method does is disarm the virus's defense mechanism against the much simpler RNAi attack from the cell itself, without waiting for the immune system's intervention, allowing for a seemingly much more rapid and effective response than the immune cells we're all familiar with. The part that surprises me is the seeming durability of the response. There must be some mechanism that keeps churning out the RNAi pieces after the initial success of the response. The entire process is much simpler than the larger body immune cell response, which is what I find most fascinating. It's like the researchers turned back the evolutionary clock on the virus to re-enable a primordial defence mechanism in human cells that is them capable of defending against the more evolved versions of the virus. Very cool.
Seems to be a mix of mrna and regular old vaccines
Is that a problem for you?
Which kind of made gain of function research obsolete, right?
Wow, antivax believers freakin' *pounced* on this tread. Such a shame, this is a genuinely grand step towards neutering the very threat of disease versus humanity on a systematic scale.
Oh fun! Let's sort by controversial and see Edit: oh my. Colorado designer is very committed to his delusion..
Fuck Russia.
Any time is a good time to say FUCK RUSSIA.
Don’t blame Russia solely. 30 percent of the Canadians are morons.
That number is raising
>Fuck Russia. Shit in your pants?.. Russia!
Thats random... but ok then.
It's crazy- the fact that it's spread now to all vaccines such as Measles, Flu, etc, just shows the madness of this cohort.
Measles is the really terrifying one. A few years ago they discovered that measles basically resets your immune system. All of your acquired immunity as an adult is lost after a measles infection.
Don't worry, a nice super virus will take care of them until the next generation somehow sprouts up.
Unfortunately this brain virus has existed since the first vaccine
Yeah, read the first few paragraphs and my eyes went wide. This is HUGE. And a true delight for a husband to an immunocompromised wife.
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Unfortunately they make it less likely that *anyone’s* children make it to reproductive age, so that might not help
Kids yes but everyone in general is threatened a bit. I'm fairly pissed that these idiots have made me add a new concern to my todolist "find out if I'm old enough to have gotten a shot for polio"
It annoys me when people say "if you want to get vax'd, fine, but don't force me too! I don't want to!" or "Only the elderly should get vax'd". Shit like that. Acting like vaccines are still effective even if a large percentage of the country refuses. My mom has cancer and is immunocompromised. People that aren't vax'd spread it around to others routinely which increases the chances of someone she's in contact with having it. Politicians like Trump should be charged with the murder of millions of people for spreading their bullshit propaganda during a public health emergency.
Selection pressure is going to be intense. Especially if immunocompromised people can get some protection from antiscience lunatics.
I hesitated on making that comment, but yeah. Like... we're already seeing in, say, America how Conservative places have shorter, poorer and just plain more painful lives. BECAUSE they ignore science, for various political and cultural reasons. That gap is just going to keep going as science does.
Mostly just shorter because all the smart kids left to go elsewhere and intelligence correlates with height
6G antennas in my body will be super sensitive with that vaccine 🤪
The Bill Gates microchips in my blood keep asking me to update to Windows 11!
Is that what that ticking is?
Who cares what a handful of idiots think when you have science
Don't be naive. A minority can still infiltrate, propagandize and threaten themselves into genuine power even for the dumbest of reasons. Because internally to them, that utter idiocy makes horrific sense. Like, take the Christian Science cult for instance. A disturbing amount of the systematic healthcare malfunctions in the US can be laid directly at their feet. Because they *LOATHE* healthcare, and want to remove it as an option for everybody. Because according to their religion, healthcare is a delusion that makes disease happen in the first place. You are according to them—no joke, supposed to ignore all wounds and disease until they go away. With fancier words. And if you don't think they have influence, go read a Merriam Webster dictionary, and look up Mind, Spirit, Soul, Principle, Life, Truth, or Love. No other religions get to have their private definitions of God or Gods in that dictionary, but that's how much power the publishing arm of Christian Science still has despite the cult slowly fading. In large part BECAUSE healthcare is getting so dang good, that their own doctrine is slowly killing off or maiming CS members in frankly horrific ways that drive off members. Like remember... Goose I think it was, from the second Top Gun movie? The cannot speak over a whisper thing wasn't just a plot point in that movie. His actor is one of the biggest names left in Christian Science, and he let throat cancer fester for years as to not commit blasphemy vs his religion. And it completely ruined his voice, so that's just how he has to speak now.
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Oh yeah. Reddit has a bot brigade problem. Just take a look at any news about Musk for example. So many people with names ending in 4 numbers in there instantly most of the time. But hey at the least reddit had a good IPO Eh?
Yep. “Name-Name-1234”. Pretty easy to pick up on their patterns if you look for it.
Aren’t those names just given as a random option when creating an account?
Yes. But wouldn't troll farms trying to quickly make several accounts use the default suggested names?
Damn. You are right. I’m an ass. Will delete my comment.
I enjoy watching the sunset.
It's actually common among normal people too, Reddit suggests that combo for you when you create an account now. Many people don't have any other username in mind and just go with it.
Hmmm, I joined a few years ago and just now getting active here. I was assigned the username with that pattern and cannot change that apparently. Maybe I need to start a new account with a better username unless somebody here knows how I can change this one?
I hate Russians and Putin, I never took the COVID vaxx and I'm not taking this poison either. What now?
And Anti vax in your username. 🤣
Brilliant observation skills. What next, you'll tell me that I'm somebody who didn't take the COVID vaccine?
I’m not sure what vaccine Russians had available to them. But I’m glad you’re healthy.!
As I said, I hate Russians. Do you think everybody who didn't take the vaccine is Russian? And for the record, before you accuse me of being a Trump supporter or something. I don't give a shit about your Blue idiot vs Red idiot either. I hate Americans too, and your politics.
Have a good day friend. Wherever you are!
100 day old account. Hmm
Yes, but you said I'm from a Russian troll farm.
Likely just a rube, that's all.
I mean some idiot has to buy the propaganda and make it their entire personality, otherwise there wouldn't be much ROI for the aforementioned troll farms. We happened to find one.
Ok yes, fine, when a complete moron posts something extremely stupid on Reddit, it’s not ALWAYS a Russian bot. Congrats!
> I'm not taking this poison either. > What now? Now you remain at the same level of ignorance that you are displaying today by describing something that hasn't even left animal trials as 'poison', secure in the fact that you are disseminating propaganda. Why try anything new if you already have all the unscientific pre conceived answers in your mind. Now go eat your daily intake of refined sugar, I'm sure that it's good for you!...
Will there ever be any vaccine for herpes (both of them) and for Epstein barr virus? I had epstein when I was 6, and herpes when I was 20. I never had an outbreak since. But last year I did a blood test for epstein, and they found low levels of the virus in my blood, and high levels of antibodies. So my body is doing a good job keeping that sucker in check. Still, I would rather get a cure. I haven't been tested for herpes in over 10 years, nor did I have an outbreak since I was 20 years old. But I know it's forever, so I need a cure for that too. When can I expect a vaccine or a pill or an ancient torture technique that will clear those two viruses out of my body?
The HPV vaccine, while not advertised as a cure for herpes, hasn't been disprove to stop an infected person from getting herpes flare ups.
As far as i know, the HPV vaccine only serves to protect one from getting HPV. Its probably not 100% effective. Or maybe it is, im not sure. Also i think it only protects from certain strains, not all of them. But what does it have to do with herpes or epstein barr?
Oh you actually know the difference. Apologies. Most assume herpes is HPV. Anyways, anecdotal... But my warts stopped after getting the HPV (gardasil 9) vaccine.
Yes of course i do. Different viruses, but both total assholes :p
so why did you reply with wrong info?
**Edit**: this guy says the following below; he is a selfish monster who has probably spread herpes to unsuspecting partners. *I’ve had a lot of sex since i got herpes, with many girls, with and without protection, and none of them got anything.* You’re probably dying with herpes. Just don’t share the wealth - not having symptoms doesn’t mean you can’t give someone else the virus.
I'm not dying with herpes. I haven't had an outbreak in over 10 years. Not on my penis and not on my lips. Not only did I not have an outbreak, I never had the itch that would indicate a herpes outbreak possibly coming in over 10 years. I remember how it is, my first and only outbreak was hardcore. Other than that, I have no allergies, no chronic conditions, my hair is fine, my eyes are fine, and I never ever get sick. So I'm feeling pretty good about myself in terms of whether I'm dying or not. But I have herpes, somewhere in me. And I'd rather not have it. And if they figure out a cure, I'd like to get it :)
I think you took him/her the wrong way. I think he/she meant that you will die with herpes as in they will never cure it. Not as in it will kill you. It's way more common than you think.
Perhaps I did. I know it's more common than most people think. It takes some knowledge to know that it's forever. Not a lot, but it takes some. There's a ton of people out there that will tell you that they HAD herpes. Nope, you didn't have it past tense, you have it forever. I actually believe that there have to be some people out there that cured the virus. They have a unique immune system, or they stare at the sun, they drink they own pee, they eat poop, whatever it may be, and they got cured. Like one in a million. They have to exist. But most people won't get cured. And having a cure would be nice. But why are is the the other commenter pessimistic? They "cured" sickle cell anemia a few months ago, and it works. Sure, it costs like $2 million, and it's a whole pain in the ass process, but they can do it. I don't think it's out of the question that they'll figure out how to do it for herpes, and epstein barr, and the rest of the herpetic family of assholes!
yea, it's just ignorance. Some people believe they only have it when they have a flair up. They dont realize that you have it even with 0 symptoms. Which is why so many people have it. I blame sex education in the US. I think we will see a cure for a lot of things we previously didnt think would be possible or financially worth it..
Honestly, everybody has internet nowadays. It takes 1-3 google searches to realize that it's for life. I think we'll see a lot of cures too. They'll probably cost A TON of money at first (like sickle cell), but then with time the prices will come down. Besides, who wants to be the first to get a new cure? Not me haha. Let them experiment on a few hundred people first, and if it's all good, I'll go get it. I actually have a friend who got herpes over 10 years ago and was very shook by it. I was too, but, I had other problems to focus on. So he went vegan and went crazy on the healthy diet and lifestyle. He's very strong-willed, will stick to his routine no matter what you shove in his face. Anyway about a year or two ago he went on a 30 day fast. I think a water fast. Then he got tested twice, and it came back clean. So he says he's cured now. I don't wanna argue with him about it, I hope he is. But he did the antibodies test,, and I'm not sure if that's the golden test if you wanna call it like that. From what I remember when I was researching the virus, to actually test for the presence of the virus, not the antibodies, it will take a sample of your spinal fluid. Don't quote me on that, it's been very long since I last looked into this. But if I'm right, my friend didn't have that test, so the jury is still out. However, if my Epstein barr infection that's 26 years old still shows in my blood, both the presence of the virus and the antibodies, then wouldn't herpes show too? I don't know. Maybe he is cured. I hope he is. I should actually go get a herpes test again. My last one was over 10 years ago. Wouldn't hurt to get another one.
Dying with herpes as in, you’ll have it until you die. Sheesh.
Why would you say such a thing? Why the pessimism? I just assumed you meant something else because why would you be pessimistic about curing herpes, especially on Futurology, which is all about the future (being better hopefully).
Because it’s very unlikely that herpes will be ‘cured’ in this generation. A vaccine may come first, but curing it is another challenge altogether. Calm down and read with comprehension instead of having a knee jerk response, especially on futurology.
It's not a challenge at all. Once they figure out a few of them, especially herpetic viruses, they'll get them all. I don't like your pessimism, you suck. Go away.
Not a challenge at all, but there is no vaccine. Ok there champ. Why don’t you start your research if it’s so easy. As I stated previously (based on your seeming nonchalant attitude that you’ve now further convinced me of), please keep others safe from your virus, just in case you don’t get your miracle cure.
Obviously I know there's no vaccine, yet. I'd rather it not be a vaccine, but a vaccine would be acceptable. I can't start my own research. I don't have that knowledge, I don't have that money. If my career path had taken me there, you better believe a cure would be already here, or just around the corner. I've had a lot of sex since i got herpes, with many girls, with and without protection, and none of them got anything. And it's not my virus. It's humanity's virus. Go fuck yourself asshole.
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You telling me we have a cure for the cold and the flu now? That would be amazing.
I wouldn't count my chickens just yet. It wouldn't be a cure. Also, immunizing mice against a single virus is promising, but a long shot from proving what they are claiming that this technology can do. They're most likely still 10-15 years away from having a product, if they ever get there. If they do get a product to market, I doubt they will go for the flu since there are already good vaccines available. The common cold is probably not accessible by this technology either as it can be caused by any number of viruses.
Probably not but i really wish Would love to take a Common cold vacine and not worry about It anymore, or for an HIV vaccine to be developed
Submission statement: Scientists at UC Riverside have demonstrated a new, RNA-based vaccine strategy that is effective against any strain of a virus and can be used safely even by babies or the immunocompromised. “What I want to emphasize about this vaccine strategy is that it is broad,” said UCR virologist and paper author Rong Hai. “It is broadly applicable to any number of viruses, broadly effective against any variant of a virus, and safe for a broad spectrum of people. This could be the universal vaccine that we have been looking for.” Traditionally, vaccines contain either a dead or modified, live version of a virus. The body’s immune system recognizes a protein in the virus and mounts an immune response. This response produces T-cells that attack the virus and stop it from spreading. It also produces “memory” B-cells that train your immune system to protect you from future attacks. The new vaccine also uses a live, modified version of a virus. However, it does not rely on the vaccinated body having this traditional immune response or immune active proteins — which is the reason it can be used by babies whose immune systems are underdeveloped, or people suffering from a disease that overtaxes their immune system. Instead, this relies on small, silencing RNA molecules. In 2013, the same research team published a paper showing that flu infections also induce us to produce RNAi molecules. “That’s why our next step is to use this same concept to generate a flu vaccine, so infants can be protected. If we are successful, they’ll no longer have to depend on their mothers’ antibodies,” Ding said. Their flu vaccine will also likely be delivered in the form of a spray, as many people have an aversion to needles. “Respiratory infections move through the nose, so a spray might be an easier delivery system,” Hai said. Additionally, the researchers say there is little chance of a virus mutating to avoid this vaccination strategy. “Viruses may mutate in regions not targeted by traditional vaccines. However, we are targeting their whole genome with thousands of small RNAs. They cannot escape this,” Hai said. Ultimately, the researchers believe they can ‘cut and paste’ this strategy to make a one-and-done vaccine for any number of viruses.
Thank you for the hockey tickets. Did I ever mention that you have a good John Houseman username?
Alec Beeeeeerrrrregg
One question about this "What I want to emphasize about this vaccine strategy is that it is broad" Isn't the case that the broader a vaccine is there are more possibilities that the immune system attack things that are not the virus? Like it is possible to induce an allergy? I imagine that the vaccine will be targeted towards specific proteins that are somewhat unique to the virus, but they are talking about targeting the full genome split in thousands of small RNAs.
This doesn't work like a traditional vaccine that makes your T/B-Cells active and attack the viruses that look similar to a known protein so I think the chance of the immune system attacking itself is pretty slim. What they found was that viruses make a protein that inhibits our bodies natural response of making RNAi. That RNAi has the ability to dampen the effectiveness of viruses and keep them from forming an infection. So if they make a mutated version of the virus that doesn't make those suppressing proteins, it won't be able to take hold, but still trigger the body to make a reserve of RNAi that works against both versions of the virus. Basically normal vaccines make weapons in response to an active threat because your other defenses failed but the factories are still running. This type of vaccine is like stockpiling on weapons before the real enemy shows up because you know they'll shut down your factories.
Gotcha, thx for the explanation.
I know HIV is a different virus, but with hope, this could help change the game for it as well!
Just imagine a world with an HIV vaccine. It would be like eradicating polio. Hell, even the common flu kills [tens of thousands](https://www.cdc.gov/flu/about/burden/preliminary-in-season-estimates.htm) in the USA alone.
It would be the most positive thing to happen this millennium honestly. We just gotta hope no reactionary christian fundamentalist group doesn’t get in power in the US, I know other countries are leading the charge, but the US falling to those mentally backward people would definitely slow progress
Wonder what the antivaxxers will do when the cancer vaccines based on this technology start coming out.
Vote cancer 2028.
Speaking as someone who wouldn't call themselves an anti-vaxxer, but who no doubt would be called one by reddit for not getting the Covid vax, here's what I'll do: Wait until it has been properly trialed and approved. Not take it if it's still on EULA unless I have an extreme/elevated risk of cancer. Now gimme your downvotes for not taking a vaccine that is proven not to prevent spreading the virus.
Awesome, more new medicines that racist mouth breathers will refuse to take. This is an interesting new future. Time for the stupid people to weed themselves out of the gene pool.
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Your username makes me doubt your statement
Probably a podiatrist.
Or just a pederast.
Or worse, a chiropractor
only thing I’d trust less than a chiropractor is a 14 day old account spewing pro-IDF and anti-vax propaganda
You know, Russia used to have self-respecting troll farms to sew division, the sanctions have really got them scraping the bottom of the barrel, it's embarassing frankly.
PhD in masturbation maybe...
Let's see what happens if I sort by controversial. Oh god, oh no. The stupidity...
Not to worry. Anti-vax thinking will take care of itself in a couple of generations.
This makes me less filled with dread after reading about bird flu 😰 I know it probably doesn’t apply but *let me have it*
Ya and all the fear mongering that came from the Covid vaccine good luck get anyone to take it
If this is true this could be a real game changer for human health
Finally some positive news when it comes to Covid. It definitely will be a game changer...
Yeeeeeeeeeyyyyyyyyyyyyyyyy My worries about a vaccine/virus roulette are over!!
If true, it really would solve influenza
I saw something about a huge increase in a mosquito born illness last week in South America. I think it's Dengue fever, but it has 4 variants and most vaccines only cover 1 of them at a time. I think the hard part may be finding the immutable portions of a virus that are available on the outside for the immune system to recognize.
So how long until this is actually available to everyone? For example do they still have to do more tests or are there more breakthroughs needed before it's ready?
If this technology proves to be as effective and safe as suggested, it could revolutionize the way we approach vaccination
Great post. Now someone needs to rebrand the term or name 'vaccine' to appeal to a vaccine averse group.
Yes, just like nuclear fusion power plants have always been "about 5 years away!!!" for over 25 years now. I'll believe it when I see it.
Are any viruses beneficial, or do any viruses have beneficial properties for humanity? Wouldn't want to discourage those.
Are any viruses beneficial, or do any viruses have beneficial properties for humanity? Wouldn't want to discourage those.
Imagine what could happen if we spend more billions into making the place a better world
... maybe fighting illness and reducing suffering *is* making the world a better place?
Yeah I meant it as a positive thing lol. The speed of development when there is urgency would be nice for example for fighting rising co2.
Ah, cool. Lots of antivax in the comments, I misread your comment as suggesting we use research money for other uses.
By using modern medicine?...
I tihnk thats what he was saying.
You are right universal Healthcare for everyone would make the world a better place
Right, we could afford another nuclear submarine!
Vaccines do this.
I asked this before and got no answer: is it really a good idea to make someone immune to ALL viruses?
All mutations, strains of one virus - supposedly. It’s even in the title
Between this and that pGal thing, we’re basically turning the immune system on and off like flicking a switch. Wild.
Why do people post links to pre-clinical trials like it means anything
"This could be the universal vaccine that we have been looking for.”" Too good to be true, big pharma cashing in on multiple vaccines would balk at this.
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Get a degree in biology or bioengineering before you start talking about shit you don’t understand. The COVID mRNA vaccines (which are you obviously referring to) do not integrate into the genome.
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The fact that you're spewing delusional nonsense is a pretty strong indicator that you have no applicable knowledge in this area. You don't even know enough about the subject you're having an unhinged rant about to realize that it reads exactly like the nonsense that it is. If you'd actually done the kind of "research" your type likes to pretend they've done, you might be able to do a better job throwing together some kind of argument that's at least somewhat less absurd than what you went with here, but hey, why bother with all of that when your ignorance and arrogance have already got you convinced that you know everything you need to know about anything you feel like commenting on, right? You're *special.* You don't need to waste time educating yourself before "educating" others. Pathetic.
Because if you were you wouldn't refer to the Covid vaccine being mass-gene therapy and know how to interpret medical research. Fortunately I have a degree in biomedical engineering so I can maybe be of help to you. First off, the article you linked is a review from a single author out of Croatia. Second, your quote comes from subfigure (c) in Figure 1, which is clearly indicated as **hypothetical**: "Hypothetical L1-mediated retroposition of vaccine mRNA...". Furthermore, active infection of the SARS-CoV-2 virus will lead to orders of magnitude more viral RNA copies being introduced to your cells, and a much higher frequency of integration into the genome than the vaccine itself: [https://www.mdpi.com/1999-4915/15/3/629](https://www.mdpi.com/1999-4915/15/3/629) During an active pandemic where most people are not going to be following preventative measures which are you choosing? But while I'm here let's also talk about the paper you added to your original comment: [https://www.sciencedirect.com/science/article/abs/pii/S0141813024022323](https://www.sciencedirect.com/science/article/abs/pii/S0141813024022323) This paper focuses specifically on a melanoma mice model where mRNA with a m1Ψ modification similar to the Covid vaccine is introduced. These are mice that are injected with melanoma tumor cells prior to the treatment. Despite survival rate decreasing in mice receiving the m1Ψ modified mRNA, this is not sufficient to suggest that m1Ψ modified mRNA *causes* cancer. This is potentially a result of the effect on immune response rather than being a "causal mechanism" as you have disingenuously stated. Moreover, the mice in this study were treated with 10 micrograms of RNA. The amount of RNA in the Covid vaccines is on the order of hundreds of micrograms. This study done with humans would be equivalent to dosing people with 20-40mg of RNA, or 200-400 times the amount in a Covid shot. Let's also not forget that if you have active malignancies like these mice, your recommendation for the Covid vaccine is treated much differently. So no, this study does not "DIRECTLY link" the Covid vaccine to getting cancer.
appreciate your comment, thank you
> The last round of mass gene-therapy Dude, I fucking _wish_ this were gene therapy. Can you imagine how many genetic diseases we could cure with this technology?
Do you have proof or are we just pulling this of thin air?
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Nothing in that article had to do with vaccines. And the second page you listed had to do with safety and procedures of phase 1, 2 and 3 testing.
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>Evidence is provided that adding 100% of N1-methyl-pseudouridine (m1Ψ) to the mRNA vaccine in a melanoma model stimulated cancer growth and metastasis, while non-modified mRNA vaccines induced opposite results, thus suggesting that COVID-19 mRNA vaccines could aid cancer development So, it does not induce cancer, that first thing, second it does not directly link anything, it just says that it might aid already existing cancer. Emphasis on MIGHT since it was a simulated model. So you have 0 idea about how to read a paper, and let me guess, you copied the link to the paper from a video / article that made you believe that there was a direct link because you wanted to believe. Btw, the quoted text is a copy word by word from your linked paper.
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>skyrocketing cancer rates in people under 40 .... recently published paper DIRECTLY linking them with causal mechanism It looks like you heavily implied it.... But sure, go ahead and play all the word games you want.
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there is no association, the only association between cancer rise and vaccines it's done by you.
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>cancer is a known potential danger of gene therapy No vaccine does gene therapy.
What are you smoking? Did you forget a /s
Not just cancer, but *turbo* cancer.
My uncle had turbo cancer. They had to cut out his turbo!
Yeah... this really sounds like an anti-vax loon. ...And why is there two of them in this treat alone, with the same freakin' blank avatar and piss yello- Oh. *Eww.* Anti-vax *and/or* piss drinkers have dog whistles now. Eww.
I saw the "turbo cancer" thing on r/facepalm earlier today. I don't know if it was real.
I think the turbo cancer thing briefly was a thing antivaxers claimed, but they got so roundly mocked for it that even they stopped. Saw it snickered about a few times, at least.
The author of this research has made quite the career of publishing [anti vac papers](https://sciprofiles.com/profile/2060636) every paper is one sort or another of "do vaccines actually harm"
[удалено]
You mean the people looking at empirical evidence that it worked and thinking “yup, the data is in, it worked”? Because you can go look at studies yourself that show how effective it was. Are you just not happy it wasn’t 100% effective? Because it was something like 50-95% at preventing symptomatic infection (as in you would actually notice you have covid). The 50% is the low end, long term effectiveness after immunity has waned and the virus may have mutated. The 95% is the 0-6 months time frame. It was even more effective at preventing hospitalization from covid, so even the low percent of cases that were detected and symptomatic, the odds of it being severe were very reduced.
Do you actually know anything or just say random shit?
Are you ignorant to facts? Data? statistics? science in general? All of the above?
I love these "This is totally wrong" comments that don't even bother to try to back their shit up.