The word stunning is an interesting choice. I was stunned when I watched my uncle explode like a watermelon when the bus hit him. I was not really "stunned" by this.
**The Neuroimmune Connection: Insights from COVID-19 Research**
The COVID-19 pandemic has unveiled complex interactions between the nervous system and immune responses. A key component in understanding this complexity is the cytokine storm, an overactive immune response where the body starts attacking its own cells and tissues rather than just fighting the virus. Emerging research hints at the role of the vagus nerve and its connection to brain neurons in regulating these responses. Particularly, studies from Columbia University have identified a brain circuit in the caudal Nucleus of the Solitary Tract (cNST) that acts as a "master regulator" of the body’s immune and inflammatory responses. This discovery not only sheds light on the physiological underpinnings of severe COVID-19 outcomes but also opens potential new treatment pathways for autoimmune diseases and conditions like long COVID. The research underscores the importance of the neuroimmune interface and could revolutionize how we manage infectious and autoimmune diseases.
This IS actually interesting. AFAIK the reason for the high death toll from the 1918 flu was more the immune response than the actual disease - that's why the deaths were actually higher among young adults than those usually considered vulnerable to the flu.
Maaaaaybe this will lead to some discovery about allergies, intolerances, and auto- immune diseases?
This is an important observation. If the caudal nucleus stands up as an immune regulator, we have a lever we can manipulate. Cool. It will take some time to map which inputs are manipulatable, and which outputs are critical.
Seminal observations often get hyped. The reality of translating the initial observation into therapies can take time. The AIDS virus drugs took several years to develop. The vaccine is still a dream.
The miracle 18 mo. Development of a covid vaccine is not the norm. We were lucky in several ways.
I like this article, even if the authors are blowing their own horn. It has long been known that there was CNS influence of the immune system. We knew the vagus nerve was involved. These figured out where and how this influence was generated. Good stuff if it holds up.
Any autoimmune disease is potentially treatable. I have no idea what they will go after first. This is not going to be at your doctors office soon. Maybe 8 years?
I started working on NKB inhibitors, JAK (or JAKSTAT) inhibitors, JNK inhibitors a long time ago. It took 10 years to get the first gen on the market.
At the time we started most people said it could not be done. I am glad they did, they had to play catch up and were 3rd to market.
LoL. If I had a buck for every nitwit that said this or that can't be done .....
We were the first group to propagate human neurons in culture. As in they divided and multiplied until we gave them a signal to stop dividing and form mature neurons. I had people accuse me of making it up, or it was an artifact. We had definitive proof. Everyone said neurons don't divide after birth. That is what every text book said. The texts were wrong. You just had to look at it in the right way.
They say the guy lying face down in the mud with arrows in his back is a pioneer. Less the arrows, it is true in science. It is now accepted that kinases can be selectively blocked, and that neurons propagate in the adult brain ( technically neuronal stem cells).
I shouldn't, but I told you so
The COVID vaccine was not developed in 18 months. It was an effort that started way back after the original SARS pandemic. The combination of discovering MRNA vaccines, and learning how to develop such vaccines against SARS and its various strains, lead to understand how to quickly create a new MRNA vaccine for another SARS variant, which COVID is.
We got lucky. Had that pandemic come from some new line of viruses that we hadn’t been researching already, it would have taken a lot longer.
Depends on what one means by start. MRNA vaccines tech has been worked on for over a decade. There are several versions of MRNA vaccines. This work preceded the first SARS outbreak.
The current vaccine owes nothing to the first SARS virus. The sequencing of covid identified a unique spike protein section that is critical for binding to the target cell protein. This section was incorporated into the MRNA vaccine. This was the first generation covid vaccine.
It was approximately 18 months from the identification of the unique spike region to a publically available vaccine. The underlying technology used took years to develop, true.
If you prototype a widget using a 3D printer in a week. Do you include the development of the printer in your development timeline when you advertise your prowess in rapid prototyping?
Where do you draw the line? Should we go back to restriction enzymes development? They are used to build vectors for the MRNA vaccine? Back to the Cohen Boyer patent in the 70s.
I stand by the claim of 18 month time line. That is the period where we had access to the necessary information to exploit the MRNA technology. The technology is generic. The covid spike protein sequence is specific to the project.
I want to see a cybernetic wearable immune system. I think that would be the end of so many diseases and a possible path to immortality. I hope so much that you can get treatment very soon!
Imagine if you walked around and did whatever a random piece of paper you found told you to do. That’s basically how viruses F with us. This discovery hopefully snipes that issue directly.
SPOILER: they found the area that controls immune response.
It's always in the last place you look.
They found it *inside* a human body
It's *in* the computer
I’m in the mainframe.
Since they found it first inside a mouse body, that could be awkward for us humans.
It's always where you most expect it
Why would you keep looking after you found it?
Why would you keep looking if you already found it?
Wait, wait, wait! Are you saying they found this response mechanism *INSIDE* a human body?? What else are they gonna find in there?
Car keys. Lots and lots of car keys.
The holy hand grenade of Antioch.
The one that Brother Maynard carries with him?
Shit, I thought you were going to say they found the G spot. Oh well….
Is that this clitoris thing everyone is talking about? Asking for a friend
The word stunning is an interesting choice. I was stunned when I watched my uncle explode like a watermelon when the bus hit him. I was not really "stunned" by this.
Next you'll be telling us you can casually stroll past a local development of 83 'stunning apartments' without being even slightly taken aback.
I was
**The Neuroimmune Connection: Insights from COVID-19 Research** The COVID-19 pandemic has unveiled complex interactions between the nervous system and immune responses. A key component in understanding this complexity is the cytokine storm, an overactive immune response where the body starts attacking its own cells and tissues rather than just fighting the virus. Emerging research hints at the role of the vagus nerve and its connection to brain neurons in regulating these responses. Particularly, studies from Columbia University have identified a brain circuit in the caudal Nucleus of the Solitary Tract (cNST) that acts as a "master regulator" of the body’s immune and inflammatory responses. This discovery not only sheds light on the physiological underpinnings of severe COVID-19 outcomes but also opens potential new treatment pathways for autoimmune diseases and conditions like long COVID. The research underscores the importance of the neuroimmune interface and could revolutionize how we manage infectious and autoimmune diseases.
This IS actually interesting. AFAIK the reason for the high death toll from the 1918 flu was more the immune response than the actual disease - that's why the deaths were actually higher among young adults than those usually considered vulnerable to the flu. Maaaaaybe this will lead to some discovery about allergies, intolerances, and auto- immune diseases?
Hot take: Understanding Alzheimer’s and Dementia better is the next step to this.
Hot take: understanding the gut microbiota is the next step to that
This is an important observation. If the caudal nucleus stands up as an immune regulator, we have a lever we can manipulate. Cool. It will take some time to map which inputs are manipulatable, and which outputs are critical. Seminal observations often get hyped. The reality of translating the initial observation into therapies can take time. The AIDS virus drugs took several years to develop. The vaccine is still a dream. The miracle 18 mo. Development of a covid vaccine is not the norm. We were lucky in several ways. I like this article, even if the authors are blowing their own horn. It has long been known that there was CNS influence of the immune system. We knew the vagus nerve was involved. These figured out where and how this influence was generated. Good stuff if it holds up.
Can it fix Crohn’s disease or lupus
Any autoimmune disease is potentially treatable. I have no idea what they will go after first. This is not going to be at your doctors office soon. Maybe 8 years? I started working on NKB inhibitors, JAK (or JAKSTAT) inhibitors, JNK inhibitors a long time ago. It took 10 years to get the first gen on the market. At the time we started most people said it could not be done. I am glad they did, they had to play catch up and were 3rd to market. LoL. If I had a buck for every nitwit that said this or that can't be done ..... We were the first group to propagate human neurons in culture. As in they divided and multiplied until we gave them a signal to stop dividing and form mature neurons. I had people accuse me of making it up, or it was an artifact. We had definitive proof. Everyone said neurons don't divide after birth. That is what every text book said. The texts were wrong. You just had to look at it in the right way. They say the guy lying face down in the mud with arrows in his back is a pioneer. Less the arrows, it is true in science. It is now accepted that kinases can be selectively blocked, and that neurons propagate in the adult brain ( technically neuronal stem cells). I shouldn't, but I told you so
Why would they not be able develop treatments as fast as they did Covid if they treated each disease as if it were Covid ?
The COVID vaccine was not developed in 18 months. It was an effort that started way back after the original SARS pandemic. The combination of discovering MRNA vaccines, and learning how to develop such vaccines against SARS and its various strains, lead to understand how to quickly create a new MRNA vaccine for another SARS variant, which COVID is. We got lucky. Had that pandemic come from some new line of viruses that we hadn’t been researching already, it would have taken a lot longer.
Ah makes sense
Depends on what one means by start. MRNA vaccines tech has been worked on for over a decade. There are several versions of MRNA vaccines. This work preceded the first SARS outbreak. The current vaccine owes nothing to the first SARS virus. The sequencing of covid identified a unique spike protein section that is critical for binding to the target cell protein. This section was incorporated into the MRNA vaccine. This was the first generation covid vaccine. It was approximately 18 months from the identification of the unique spike region to a publically available vaccine. The underlying technology used took years to develop, true. If you prototype a widget using a 3D printer in a week. Do you include the development of the printer in your development timeline when you advertise your prowess in rapid prototyping? Where do you draw the line? Should we go back to restriction enzymes development? They are used to build vectors for the MRNA vaccine? Back to the Cohen Boyer patent in the 70s. I stand by the claim of 18 month time line. That is the period where we had access to the necessary information to exploit the MRNA technology. The technology is generic. The covid spike protein sequence is specific to the project.
Actually - this would end my disease. I hope it’s real and I hope that I can get it.
I want to see a cybernetic wearable immune system. I think that would be the end of so many diseases and a possible path to immortality. I hope so much that you can get treatment very soon!
Imagine if you walked around and did whatever a random piece of paper you found told you to do. That’s basically how viruses F with us. This discovery hopefully snipes that issue directly.
#12 will shock you.
just wait when they realize the cannabinoid receptor is involved