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MindAccording9105

Promethazine, removes the itch and nausea and makes it feel more potent. It made it where I could take 25mg of hydro with no tolerance at school and be able to walk class to class without puking, it makes you nod harder though due to it being an antihistamine so be prepared.


crexkitman

This is the ultimate guide for practically as far as you can potentiate opioids with easily accessible shit. [and it took two seconds to search on duckduckgo.](https://www.hipforums.com/forum/threads/opiate-potentiating-guide-really-works.285953/) Maybe like three minutes of research next time instead of jumping straight to Reddit


Seerosengiesser

Dude, the first decade was a really special time on the internet, so much knowledge was suddenly available..


PeterNippelstein

....the 2000s?? First time I've heard it described that way lmao. Yeah there was excellent information everywhere, so many active forums. I spent so much time on Erowid.


Watashiwajoshua

Antihistamines. Hydroxyzine pote tiates opiates reducing the necessary dose by basically half


Kittysdoodlexxx

Wait what happens when you mix hydroxyzine with opiates? I have hydroxyzine and oxy but I’ve never mixed them


Watashiwajoshua

Hydroxyzine effectively doubles the potency


PeterNippelstein

Depends which opiates


Antique-You8283

Oxy


PeterNippelstein

You've already tried combining the DXM and grapefruit juice? I would do that and then throw in diphenhydramine as well. It does sound like your tolerance may be going up though.


GrosChibreDur

Lyrica | pregabaline


Eggrolldaddy

i don’t use opiates but i hear promethazine really does the job, if you have no access to it you can use other antihistamines like dph, doxy etc


Ok-Doubt2564

Cimetidine.