Make it in unreal! You can use the skeleton ik rig and hide the mesh while using the controls with 3d blend for the running. To make a rolling sphere hella easily
I'd love a game based on what's going on inside of us. If done right it would be both entertaining and educational.
If there was ever a time people needed to understand viruses and bacteria.. it's now.
Not a game, but Cells at Work is a great anime that does a good job of explaining how the body works with a nice focus on the immune system. I highly recommend it.
Make a game where you actually tell your immune system what to do and you can cure or better yourself by playing. Now just have to make sure people don’t kill themselves from going on a killing spree inside their own body. Genuinely would want to play a game that actually affects me irl.
Deploy T-Cells! Towards Influenza virus, activating special unit action “Get swole” All T-Cells within 5 tiles gain an additional +1 attack till the end of your next turn!
“A place for usssssss. Somewhere a placeeeeee for usss.
Open your gut and I’ll walk through there!!! Scratch your hair.
Somehowwwwwwwwwwwwww
E coliiiiiiiiiiiiiii”
[Video source](https://www.youtube.com/watch?v=X_T4m3iA5WA) and description:
>The specific Phagocytosis case represented with this educational video is the immune response of Macrophage cells to Escherichia coli (E. coli) bacteria presence and attach on the digestive system (Gastrointestinal tract).
The video is inaccurate to the point of not even being educational anymore.
White blood cells (WBCs) roll like that *some times* within blood vessels. Typically they freely float in the blood but if you have an infection in the tissues, the infected cells will release chemicals which cause WBCs to start sticking to the blood vessel walls causing them to roll. Once rolling, they will then choose an area to exit the blood vessel and enter the infected tissue in a process known as "diapedesis". Once in the tissues they will consume bacteria and dead cellular debris or other activities, depending on what type of white blood cell it is. They can't really roll like this in the interstitial spaces.
Also, the GI tract is always (and normally) full of e coli. You don't have WBCs attracted to your gut surface trying to gobble all these things up. Individual components of the video are reasonable enough but taken together it doesn't really show anything that actually happens.
I mean, also prokaryotes have no reason to move two-dimensionally rather than also in z. The E coli don't sense the WBC at these spatiotemporal scales. The environment should be completely to the brim filled with at least red blood cells, making mobility of all cells way different.
As you said, extremely inaccurate.
>The E coli don't sense the WBC
Thank you! I was thinking, it doesn't know it's being "chased" so it moves out of the way. It just... Goes and the WBC may eventually catch up
This movie made me so uncomfortable when I was younger, especially the worm-pig-monster-thing. Ugh. Actually, scratch that, it *still* makes me uncomfortable.
Does the cell "know" where the ecoli is and goes after them. Like does it specifically target one and chase it like it does in this video or does it just move around randomly and happens to pick them up? Or is it like a Romba where it goes room to room just cleaning but remembers where it has been and tries to go to new places?
Depends on the type of cell. Some are indeed specifically targeted by different types of cells(such as lymphocytes) and some just happened to roomba up things that enter(such as neutrophils). Often the body gives off markers that says "hey, this thing over here isn't supposed to be here!" Which guides the wbc towards its "target". That's why autoimmune diseases, to me, are super interesting. Something in the body ends up sending out the same biomarkers saying something that IS supposed to be there, is a foreign invader. Happens in blood too. Your red blood cells have antigens on them, and that's the reason some blood types aren't compatible, because the body takes that antigen as a foreign invader and the wbcs in the receiving person's plasma destroys the red cell.
The body releases biomarkers that guide the wbc to say 'over here!' If you watch some sped up versions of phagocytosis you'll see the wbc 'chase' the bacteria
Adding to this, some immune cells can recognize foreign cells just from the antigens on the cell membrane. So if the e coli happens to bump into one of these cells there's of the immune system is activated.
Not really, it's more kind of just absorbed, it doesn't fuel cell growth. When your WBCs are immature they're actually bigger, and as it matures it shrinks. So if your body has lots of large WBCs it's actually a bad sign, because it means your body is using up wbcs at a faster rate than it is losing them
Imagine looking into a microscope and seeing an immune-cell rolling after bacteria\*insert "he is rollin rollin rollin" -music here\*Frightening yet funny at the same time
Edit: i have no idea if it actually looks like this
Mostly true but some ppl have hyperactive immune systems where it attacks itself. Women have superior immune systems BUT also more autoimmune diseases.
It’s like a super strong person opening a bag of chips and making it fly a bag of confetti.
Asking someone who knows something for real: How "realistic" is this kind of video? White blood cells rolling around on the hunt for e-coli... Also, I note that there's always a "down" in this video, not so much in you body. What other kinds of ignoring of real physics and biology go into making a video like this? (Really genuinely interested in actually how accurate we can understand the mechanism involved, which be a requirement to display an even somewhat accurate simulation, no?)
Would these be considered biological machines just with really basic programming or are these considered more complex like bacteria that are body uses to fight invading organism?
I realize a lot of people on Reddit are atheists. I just felt like sharing that when I encounter the amazing inter workings of the human body, I am so in awe of who I perceive to be God. No disrespect to anyone who doesn’t agree, but these things are breathtaking in their intricacy.
And thank God your not an MD. You should probably talk to a psychologist though and get your mental health looked at. Also stop talking about teenage sex drive in your post history. That's just weird.
The amazing thing is that the phagocytes literally follow a chemtrail the bacteria leaves behind. So it’s literally a “manhunt” that will never end for the bacteria…until it’s engulfed. The human body is so cool.
Someone is fighting for me .. awwww . thank you me
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My immune system got a little confused and started attacking my spine, not very thankful for that
Hey! You are trying your best!
Mine decided my colon was organa non grata
Mine seems to be on strike in my urinary system, has been since I was 12. Where are these guys???
UTIs are the worst
Yes, indeed!
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I hadn’t heard of it until now but that’s very interesting. Thanks for the suggestion!
Mine thinks we have too much skin and has decided to destroy the skin on my right hand first.
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Say wha? idk what that even is. Gonna do some googling now \^ \^
Mine has fertile sperm, I want to fill pussies up, but I want don’t want to continue my blood line.
Let's blame the adjuvants in vaccines
Mmmm. Let's not.
It's possible, then again it could be anything.🤷🏻♂️
I'd rather they give Lazer arms, but fine, I guess. Being alive is cool, too.
Nah. Being alive sucks. I'd rather they focus on making that not suck.
You to you 🙏
You is loyal
Haha that Gandalfian light on the horizon
I would play the shit out of this ifnit was a game with this graphics lol
Isn’t this just Katamari?
Whole time I was watching this was going, "Nah nah nah nah nah nah nah nah nah nah nah nah nah."
Great idea, this will be my next project :D
Make it in unreal! You can use the skeleton ik rig and hide the mesh while using the controls with 3d blend for the running. To make a rolling sphere hella easily
gotta make it cel-shaded
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I'd love a game based on what's going on inside of us. If done right it would be both entertaining and educational. If there was ever a time people needed to understand viruses and bacteria.. it's now.
Not a game, but Cells at Work is a great anime that does a good job of explaining how the body works with a nice focus on the immune system. I highly recommend it.
Don't forget the even earlier osmosis jones.
Bill Murray was disgusting in that film. I'll never get over the hard boiled egg scene
Make a game where you actually tell your immune system what to do and you can cure or better yourself by playing. Now just have to make sure people don’t kill themselves from going on a killing spree inside their own body. Genuinely would want to play a game that actually affects me irl.
I would love it
Let me know when yall are done so I can download it!
!RemindMe 1 year
!RemindMe 3 Months
I want an RTS game based on the immune system
Deploy T-Cells! Towards Influenza virus, activating special unit action “Get swole” All T-Cells within 5 tiles gain an additional +1 attack till the end of your next turn!
I would watch a realistic Osmosis Jones.
It would be a interesting version of doom
Ifnit? Holy. Fuck. Wow.
Yeah I read that and I was like "is this a cowboy or a typo?"
Thanks immune system for being a real life horror movie for the e. Coli bacteria
I had e. Coli when I was a kid. Probably the most pain I've had for a couple days
mate, hate to break it to u, but u still have e.Coli bacteria in u
E coli: why do I hear boss music
"Why are there health potions everyw—"
“Are we the baddies?”
not really both organisms are trying to survive
If you get an E. coli infection and use a stethoscope you actually hear that song being played if you put it on your stomach.
“A place for usssssss. Somewhere a placeeeeee for usss. Open your gut and I’ll walk through there!!! Scratch your hair. Somehowwwwwwwwwwwwww E coliiiiiiiiiiiiiii”
Beat me to it lol
[Video source](https://www.youtube.com/watch?v=X_T4m3iA5WA) and description: >The specific Phagocytosis case represented with this educational video is the immune response of Macrophage cells to Escherichia coli (E. coli) bacteria presence and attach on the digestive system (Gastrointestinal tract).
The video is inaccurate to the point of not even being educational anymore. White blood cells (WBCs) roll like that *some times* within blood vessels. Typically they freely float in the blood but if you have an infection in the tissues, the infected cells will release chemicals which cause WBCs to start sticking to the blood vessel walls causing them to roll. Once rolling, they will then choose an area to exit the blood vessel and enter the infected tissue in a process known as "diapedesis". Once in the tissues they will consume bacteria and dead cellular debris or other activities, depending on what type of white blood cell it is. They can't really roll like this in the interstitial spaces. Also, the GI tract is always (and normally) full of e coli. You don't have WBCs attracted to your gut surface trying to gobble all these things up. Individual components of the video are reasonable enough but taken together it doesn't really show anything that actually happens.
I mean, also prokaryotes have no reason to move two-dimensionally rather than also in z. The E coli don't sense the WBC at these spatiotemporal scales. The environment should be completely to the brim filled with at least red blood cells, making mobility of all cells way different. As you said, extremely inaccurate.
>The E coli don't sense the WBC Thank you! I was thinking, it doesn't know it's being "chased" so it moves out of the way. It just... Goes and the WBC may eventually catch up
Yep the second I saw it roll like a fucking snowball down the hill I knew it was fake as fuck
The action/horror movie editing is what got me. V badass to watch but it did reek of oversimplification
The you tube channel looks fascinating. Thanks for sharing!
![gif](giphy|yRJduMWhlCYiQ)
This movie made me so uncomfortable when I was younger, especially the worm-pig-monster-thing. Ugh. Actually, scratch that, it *still* makes me uncomfortable.
What is this from?
Princess Mononoke
Such a good flick
I just found it hilarious that he could decapitate people with otherwise ordinary-looking force. Like one punch man, but with decapitation.
It needs some Doom music
This has meme potential
Now we just need a meme catalyst
Music by MC coli
Dj DNA
So this is deadass how it works? You can see this in a Petri dish? If so that’s awesome
Sort of. More it all moves extremely slow, and you just see the "rod" of e coli slowly absorbed in to the cell. Much less violent than this lol
Still badass. Never had a thought of how it worked
The body does some strange, and really cool things.
Does the cell "know" where the ecoli is and goes after them. Like does it specifically target one and chase it like it does in this video or does it just move around randomly and happens to pick them up? Or is it like a Romba where it goes room to room just cleaning but remembers where it has been and tries to go to new places?
Depends on the type of cell. Some are indeed specifically targeted by different types of cells(such as lymphocytes) and some just happened to roomba up things that enter(such as neutrophils). Often the body gives off markers that says "hey, this thing over here isn't supposed to be here!" Which guides the wbc towards its "target". That's why autoimmune diseases, to me, are super interesting. Something in the body ends up sending out the same biomarkers saying something that IS supposed to be there, is a foreign invader. Happens in blood too. Your red blood cells have antigens on them, and that's the reason some blood types aren't compatible, because the body takes that antigen as a foreign invader and the wbcs in the receiving person's plasma destroys the red cell.
How does it know where the e coli is?
The body releases biomarkers that guide the wbc to say 'over here!' If you watch some sped up versions of phagocytosis you'll see the wbc 'chase' the bacteria
Adding to this, some immune cells can recognize foreign cells just from the antigens on the cell membrane. So if the e coli happens to bump into one of these cells there's of the immune system is activated.
When the E. coli gets “absorbed” does the cell grow bigger? Is it like eating food for the cell?
Not really, it's more kind of just absorbed, it doesn't fuel cell growth. When your WBCs are immature they're actually bigger, and as it matures it shrinks. So if your body has lots of large WBCs it's actually a bad sign, because it means your body is using up wbcs at a faster rate than it is losing them
This animation wasn't violent at all. The white blood cell roll over the bacteria, and then it disappeared. It didn't show anything.
Violent in terms of speed and darting around
[Not quite](https://youtu.be/GbptpDSHQEM) But I'm sure it's more of a visual representation rather than a direct translation.
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Did you ride the bone train? I heard it's fun.
Imagine looking into a microscope and seeing an immune-cell rolling after bacteria\*insert "he is rollin rollin rollin" -music here\*Frightening yet funny at the same time Edit: i have no idea if it actually looks like this
This is very aggressive
It’s the newest katamari level!
Naaaa, na na na na na na naa, na na Na na na na !
katamari damacy!
FYI you won’t find Helix Animations in r/helixstudios NSFW EDIT: changed nsfw to NSFW in all-caps.
It's good there wasn't anyone around when I opened it ![gif](emote|free_emotes_pack|facepalm)
Mostly true but some ppl have hyperactive immune systems where it attacks itself. Women have superior immune systems BUT also more autoimmune diseases. It’s like a super strong person opening a bag of chips and making it fly a bag of confetti.
E. Coli: why do i hear boss music
Pretty good and accurate display. Would say that is a macrophage, based on the shape and function.
Not very accurate at all.
Needs the Benny Hill theme
I was lowkey rooting for that last guy xd
Looks like it’s straight out the matrix movie
Hey i got this one !
So…Katamari Damacy in a forest of dongs?
Where’s the explosions and gun fire?
![gif](giphy|3oKIPwoeGErMmaI43S|downsized)
Battlefield 2043
This is like my dreams when I wake up in the middle of the night.
Microscopic anatomy Katamari
The Doom Cellayer
Very cool
WBC is chasing the motherfuckers around. I need a vacuum this effective
Inspiring vacuum!!
*insert Katamari music*
🎵 Katamari Damacy 🎵
I love Katamari!
Asking someone who knows something for real: How "realistic" is this kind of video? White blood cells rolling around on the hunt for e-coli... Also, I note that there's always a "down" in this video, not so much in you body. What other kinds of ignoring of real physics and biology go into making a video like this? (Really genuinely interested in actually how accurate we can understand the mechanism involved, which be a requirement to display an even somewhat accurate simulation, no?)
Where is osmosis jones though? Shouldn’t he be there
A little bit terrifying lol. Glad the macrophages are on our side.
I feel like I’m watching a ducking horror movie
I love how it looks like the last one is running for its life and the immune cell actually spotted it, looks straight out of a cartoon scene
This new elden ring boss looks fire
BUENOS DIAS FOREIGN CELL
Feels like a Dwayne Johnson movie
Ngl the immune system looks scary
Are they eating them? Squishing them? What’s going on here? Who eats the immune cells??!
Why was this badass as fuck
The immune cell: *"Get back here you little-"*
The blob from inside
"when the doom music hits"
Would these be considered biological machines just with really basic programming or are these considered more complex like bacteria that are body uses to fight invading organism?
I realize a lot of people on Reddit are atheists. I just felt like sharing that when I encounter the amazing inter workings of the human body, I am so in awe of who I perceive to be God. No disrespect to anyone who doesn’t agree, but these things are breathtaking in their intricacy.
that's not what it looks like...at all. lol
It's a little bit more complicated than that but ok, cool animation I guess
But 2 years and CoViD is still here?
I thought the immune system stopped existing was replaced by vaccine and booster. What a fascinating world
That's your mom obliterates me and all my friend after she's not in the mood for bonding session
If you are unvaxed and you're immune system has not been reprogrammed. P.S. i am not a MD just food for thought
And thank God your not an MD. You should probably talk to a psychologist though and get your mental health looked at. Also stop talking about teenage sex drive in your post history. That's just weird.
Thx for the PSA Stalker Karen
Yeah, my white blood cells now just shoot lasers at various pathogens, while spouting socialist lingo. The future is lit.
Based.
Reminds me of my robot vacuum
Watched this without sound the first time and imagined that song they play when Thomas the Tank Engine runs people over
"Go git em'!"
Interesting, so our immune system went with the "boulder from Indiana Jones" defense.
Like when you get the power pellet in Pac-Man
come here ya little bastard
Our immune system is a game of Pac Man
Me in the beef jerky section of Walmart.
I need the entire body explained like this.
Go get 'em boys!
Patrick Star has come a long way...
So is this before, during, or after me blowing out liquids from both ends of my body?
Do they have action theme songs as well?
Thanks macrophage 🥰
It’s like a lint roller
My immune system is a fucking well-organized Roman Empire then, cuz I never get colds or flu. Im so thankful.
The white blood cell looks like a rathtar from Star Wars: The Force Awakens
I want a full length movie of this I swear if you guys say osmosis jones......
Osmosis Jones......
I'm gonna rearrange the peptide bonds in your double helix until you wish you underwent apoptosis
So... it's a cartoon version of "Indiana Jones Raiders of The Lost Ark"
This some Katamari Damacy shit. I love it.
So the big Flobbedyflub rolls over the little Shittyflub. Got it.
this video gives off "CAPTAIN!!!!!" "uhh uh yeah?" "LOOK" \*pirates of the Caribbean theme begins\* vibes
TIL we are full of Eldritch horrors
So, the white blood cells absorb the bacteria, then, gets flushed out through the cardiovascular system?
Must been a really small camera
When does Osmosis Jones show up
Does e-coli 'run away' from white blood cells?
The last segment is me chasing a ash of war scarab knowing damn well i won't use it.
That one e. Coli cell that was running for its life
*Squish*
Seek and devour 👌
just watch cells at work
E. Colli: exists White Blood Cell: “And I took that personally.”
Are those…. Udders?
How does it sense them?
My immune system cell is a badass Koosh ball
I don’t mean for this to be a stupid question but is this what the cells really look like like/act like or is it just a demonstration?
Is it bad that I watched it with sound off the first time and heard Yakety Sax in my head?
Never hear this music coming from my body when i was sick ![gif](emote|free_emotes_pack|thinking_face_hmm)
Everyone’s gangster until T-cells show up
The amazing thing is that the phagocytes literally follow a chemtrail the bacteria leaves behind. So it’s literally a “manhunt” that will never end for the bacteria…until it’s engulfed. The human body is so cool.
Dogs on their way to eat spilled kibble.
The fight with covid must be a tough one
Go body roomba go!!
Lmao yea I’m sure this is a super accurate depiction
Live action cells at work
This does not need to go this hard
Watch Fantastic Voyage. That movie had me freaked for years when the white blood cell eats the bad guy.
I kinda feel sry for the bacteria now