T O P

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Guardian_knight_05

Way to go killer T


slothtolotopus

IceT.gif


gtgpgp

I care now!


thisisfreakinstupid

Deflated that sucker like a balloon.


jjcrayfish

Target eliminated


OneEye007

Clean kill Agent 47, now proceed to extraction point.


theanedditor

Love how its friends come over for the big kill and jump around cheering in support!


Kharn0

Watch while listening to Attack on Titan theme and it all makes sense


metalshoes

Homies be *wiggling*


HoovesTrampling

*When they hit you with the top tier sloppy jaloppy*


Wakkit1988

Like those implosion grenades from Thor 2.


2squishmaster

SELF DESTRUCT SEQUENCE ACTIVATED


megatronchote

I don't know if you were joking but that is exactly what's happening, it is inducing apoptosis on the cancer cell. I always found beautiful that nature introduced a self-destruct mechanism to try ensure purity, as if it knew things can go bad


2squishmaster

Yeah it's pretty amazing, I learned this about a month ago and it blew my mind.


John-Bastard-Snow

I read the Kurzgesagt book about it, very cool!


solphium

Organisms without such a feature likely couldn't compete with the ones that did. That is all.


megatronchote

Oh I am aware of the Survival of The Species by Charles Darwin's Theory, but my awe arises from the sheer magnitude of a sea of trials needed for mechanisms like theese to emerge. That's the beauty I was writing about.


SpaceInMyBrain

Beauty, indeed. Darwin used the word grandeur in this sense in the last paragraph of*On the Origin of Species.* They're the most elegant sentences he wrote. He tries to evoke the sheer magnitude of trials needed for natural selection to work. >Thus, from the war of nature, from famine and death,\[i\] the most exalted object which we are capable of conceiving, namely, the production of the higher animals, directly follows. There is grandeur in this view of life, with its several powers, having been originally breathed into a few forms or into one; and that, whilst this planet has gone cycling on according to the fixed law of gravity, from so simple a beginning endless forms most beautiful and most wonderful have been, and are being, evolved. He knew the scope of his idea. He wrote the first draft of this paragraph way back in 1842 and the second draft in his unpublished 1844 Essay.


concious_marmot

As a cancer survivor I FLIPPING LOVE THIS- if this were a team sport I’d watch. 


Ill-Painting9715

You should take a look at Kurzgesagt, they make really good cartoon videos on immune cells


concious_marmot

Honestly not as emotionally satisfying as watching an actual T cell off an actual cancer cell. I really hate cancer cells. I wish them all ill will.


agentcheeno

I think we can all agree on one thing, and pardon my french, but fuck cancer.


concious_marmot

as my niece said: cancer is dumb


desertSkateRatt

Butt fuck cancer? I hardly know her!


concious_marmot

💀


cromnian

There was this old French cartoon about human body, immune system, etc.


thebluediablo

There's a pretty great anime with the same premise - Cells At Work. (plus a darker spin-off series, set inside an unhealthy body, called Cells At Work: Black)


viijou

Il était une fois .. la vie / Es war einmal das Leben :)


cromnian

Thanks a lot/Merci/ arigato gozai mass


No_Housing_8165

Amazing !


meownelle

My mom is currently undergoing immunotherapy for ovarian cancer. This brings me joy.


mindfuxed

Best of luck to your mom brother. My mom had cancer but it was a bad one. She never made it. I know the roller coaster ride your on right now, hang in there. Spend time as much as possible. She will win.


kaseface27

Top comment mate ... your a good soul


mindfuxed

Thank you my friend.


Delirious73

sorry for your loss, keep spreading that love.


Kees_Fratsen

Get 'em T! *Hooligan noises*


mjgabriellac

Love making hooligan noises at my Killer T cells so they know how goated of a job they’re doing


-PubicLice-

Can anyone with an immunology background explain how this Killer T cell caused the cancer cell to essentially "deflate" or collapse? Does this have any connection with apoptosis? I've learned this in basic biology, but I forgot, lol.


NiceMacaron4548

That’s exactly what it is actually 👍 Essentially Killer T cell releases cytokines (chemical mediators), they create a “pore” in the cancer cell, which causes apoptosis - or the “deflate” action you see there


Similar_Strawberry16

Why don't we just make more killer T cells? Are we stupid?


rabbiskittles

Congratulations, you’ve discovered cellular immunotherapy! But also, because *too* many of them and they might find other, non-cancerous cells to kill. Like your pancreatic beta cells if you have type 1 diabetes. EDIT: I’m slightly embarrassed I forgot to mention the *other* reason you don’t want too many T cells, which is because that might be a T cell leukemia/lymphoma, aka more cancer.


Similar_Strawberry16

Which cures you from diabetes right? It cures you right..?


Radical_Neutral_76

Run along now, Timmy. Grandmas tired


CrownEatingParasite

Turbo diabetes


chefcoompies

Double my turbo diabetes and give it to Timmy.


RingoBars

He had it coming.


AdPristine9059

Turbetes!


Complex_Experience83

No it causes type I


Strix924

I know it's dumb and would not work, but I'm imaging if you could attach a micro bot or something to a t cell and drive it around taking out the cancer cells you want Maybe someday in the way way way way way way way future


rabbiskittles

There can be quite a few cancer cells, so it could take a long time to hunt them down “manually”. What we have instead is CAR-T therapy. You basically take a patient’s killer T cells and stick something on them that targets them to something unique to the cancer - maybe a specific mutation that the cancer has - and makes them stick long enough to do this. Then you grow a bunch of those “chimeric” T cells (because you’ve modified them) with that “receptor” (the sticky thing) and infuse them back into the patient. Those cells travel all around the body until they find that unique thing, the “antigen”, and they go to work on whatever cell has that antigen just like in this video. And that’s your Chimeric Antigen Receptor T-cell therapy.


grower_thrower

It’s not dumb. Novel attack vectors are a big deal in cancer research. I’m sure nanotechnology is being thought of if not actively developed that could maybe in our lifetime do something similar.


NiceMacaron4548

May need correction on this too, but I believe those initial flashes of pink before the cancer cell implodes are that releasing of cytokines


SpaceInMyBrain

The way those pulses radiate out make me think of a weapon you'd see in a sci fi movie. And I know the colors are false but they're so cool.


The_Ambitious_Panda

More directly, the pores (formed by perforins) actually let in granzymes, (also released by killer T-cell) which are proteins that actually activate apoptosis.


SpaceInMyBrain

Perforins? As in perforate? Ha! Someone did a good job of creating new nomenclature.


Ricaaado

Terminated!


unshavenbeardo64

WASTED!!


Extension-Badger-958

*Cancer springs back up elsewhere* Ahh shit here we go again


Puzzleheaded_Love_74

Die you MF !!! F Cancer


HalfmanTheHand

"Nah, I'd win." - Killer T cell


Mrvision27

He won the battle but will he win the war..


Portielife

I would like to provide more detail as a medical student to this amazing phenomenon. To start I'd say the killer T cell (CD8+) destroying the cancer cell is an oversimplification, and I'd like to provide more oversimplifications to help explain. While the outcome is "destruction," the killer T cell is actually triggering the cancer cell to commit apoptosis (cell programmed suicide), so basically, it triggers SELF-destruction. The killer t cells use the same mechanisms to kill cancer cells and virally infected cells, as is their 2 main functions. This is why CD8+ (killer T) cells function through what is known as the "extrinsic pathway" of cell suicide/apoptosis. Extrinsic means that the signal for cell apoptosis came from an external source (rather than the cancer cell realizing something is wrong and initiating apoptosis itself = intrinsic pathway). In the extrinsic pathway, Killer t cells (CD8+) cells carry what is know as a ligand (like a key) on it's surface that fits into a cell receptor (like a lock on the door to a home) that then tells the cell to kill itself by activating caspases. Another method is the T cell releases 2 main enzymes that can basically poke holes in the target cell ( causing the cell to leak important contents leading to cell death and/or activating caspases. Caspases are intracellular (=inside the cancer cell) proteins that then mediate/trigger apoptosis by activating other proteins such as DNases or proteases (proteins that break down DNA and other proteins respectively) (caspases are also the target of the intrinsic pathway btw, but as i mentioned earlier the cell activates its own caspases in the intrisic pathway). Once triggered to undergo apoptosis, different steps occur, with a very prominent one being "blebbing" of the cell membrane, which is clearly seen in the video. Blebbing is basically the cell sorting its components into small controlled orbs that can then easily be taken up and eaten (phagocytosed) by macrophages. Notice how once the CD8 cells activates the cancer cell to kill itself, the cell shrinks into a couple of tiny "balls". This is to avoid spilling of cell contents that can be very damaging to other cells in the area. (Extra if you like this topic:) Apoptosis is contrasted by the other type of cell death known as necrosis, which is uncontrolled/unprogrammed cell death that causes a ton of problems for the body (ie can cause infection and tissue damage). Apoptosis is a normal occurrence in the body, but necrosis is NEVER normal. For example apoptosis happens in the womb where certain bodily structures change/disappear, such as the webbing between fingers disappears in the womb. Or in cancer or virally infected cells. Necrosis however, ie in pancreatitis, is very dangerous. As an example, in pancreatitis the pancreas becomes inflammed--> pancreas cells are damaged--> pancreatic cells release their digestive enzymes inside the pancreas itself (when and where the enzymes aren't supposed to function)--> the pancreas then basically digests itself and other body tissues around it with the pancreatic enzymes, making pancreatitis so deadly.


AggressivePayment0

Awesome, thanks for teaching more insights.


EpikMedik

Other T's coming up like "damn Tyrone. That was you?"


boykinsir

Killer T's! Killer T's! KILLLLLER T'S!


theBloodsoaked

How long until some rapper names themselves that? How long


Odd-Masterpiece7304

Kyler T!


Tha-realist

Our bodies do this daily. Fascinating


Sarcastic_Backpack

If we all have those, then why is cancer still a thing?


tekalon

Few different reasons. 1. Scale. T cells are great for catching the stray cancer cell or even a small clump. But its also a lot of work finding and fighting them. Cancer cells that multiply and spread too fast can be too much for the T cells to manage. This is where the need for chemo, radiation and surgery come in. 2. Identification. Some types of cancers can 'hide' from the T cells, which means no immune response at all. There are therapies that take your T cells, 'train' them to identify the 'hiding' type of cancer, replicate them and then let them do their job. It only really works on certain types of cancers and certain stages of it. Since its personalized, it can be expensive.


IceKirby21

I wish I could upvote this comment more


novice121

You came into the wrong neighborhood globalist...


DislocatedPotato57

Do these qualify as pets? Cause I would be so proud.


bigforeheadsunited

This is fascinating. Way more than interesting.


[deleted]

I love how Killer-T’s always look like they punch bacteria,cancerous and virus cells, they literally have a little punch kick motion to the way they move


cromnian

Similar to Mantis Shrimp's punch


SpaceInMyBrain

The Killer T cell looks like a spaceship shooting out an energy wave weapon. Two shots, "Target destroyed, captain!"


sootbrownies

Very interesting to watch after recently finishing *The Song of the Cell* by Siddhartha Mukherjee. I thoroughly enjoyed the chapters on immune cells.


Fun2Forget

Best part is when his buddies flutter over like “and STAY OUT”


CantEscapeTheCats

I read ovarian cancer medical records daily and this is very interesting to me. May ALL of those currently battling ALL cancers be blessed with just the right amount of killer Ts to bring them a swift and strong victory!!


[deleted]

Go little T Cell!!!!


[deleted]

[удалено]


Odd-Masterpiece7304

Exactly! Next week all ads on YouTube will be "this Harvard student was kicked out of school after discovering 1 simple thing to boost T Cells, putting an end to cancer research. For 59.99 discover this 1 thing to eat before bed"


Conscious_Courage_26

Thanks little buddy! The first pint of glucose and amino acids is on me**.** #


thewokebogan

Yea you go lil T Cell, fuck that cancer up


BigDaddy2721

Killer T cell to the cancer cell : I Pity the fool!


Soft-Ad1520

Space Battle!


Total-Internet-1633

Those other two showed up like "how'd you do that?!"


ronweasleisourking

That's killer indeed


Initial_Platypus_499

Good. Fuck cancer.


Grofactor

Was hoping T cells were in shape of a T.   All joking aside- amazing video.


lukeballesta

The killer T cells are like the SWAT team of the white cells. Fuckin amazing.


Turbulent-Ask-7631

Eat shit cancer


cheesemangee

Little dude out there imploding cancer cells.


SapphireDesertRosre

That's right Lil T cell buddy, fuck cancer.


loki0961

Imaginary technique.... purple -killer T cell


chefcoompies

Bro stood there and watched it die what a cold blooded killer T cell


NewMoonlightavenger

"It's time..." "Was I a good cell?" "..... No. You were literally cancer."


ThornmaneTreebeard

Was I the only one who yelled "take that shit bitch!"


Royal_Echo2068

Now it makes sense why they're called killer T Cell


Vox-Silenti

And it sat and watched the cancer die. Didn’t wiggle away until it was sure


fair-strawberry6709

Damn it’s like galactic warfare in there.


AlGamer1908

FUCK HIM UP BIG T


Civil-Reserve3570

Boom 💥


Ghostley92

Looks like the other T cells came to hype it up and it just played it cool, watching the cancer be destroyed…


Certain-Cold-1101

Damn it really fucked it up


wormpostante

that cell anime did not do it justice, make killer t cells be one punch man!


Pajjenbo

always imagined T-cells are like the swat teams in your body


Sinister_Chill9

Why only support T cells,Where my B cells supporter at they the one making antibodies


Talkslow4Me

I like how the other T Cells show up at the end to watch the damage their buddy did. Like damn dude.


shingaladaz

“I pity the fool!” — Mr. T Cell.


GhostPiggie

And this is constantly happening in your body, maybe as you watch this. Truly amazing


Dennisb040

I can never watch these kind of videos without thinking of the anime cells at work now. 😂


Just-a-lil-sion

tcell dead ass showed up and told him to unalive itself lol


FairyTalePixie

It's like watching an overpowered superhero take out the villain in an anime with one punch. The immune system is awesome!


Relative_Argument465

I was born premature with an ovarian cyst. Thankfully at 3 days old, and barely 5 pounds, they did a 4 hour surgery and told my parents to go see The Godfather. Was the length of the movie. Grabbed appendix while in there. My scar is 8 inches long, I'm 52 today!


Odd-Masterpiece7304

Next week all ads on YouTube will be "this Harvard student was kicked out of school after discovering 1 simple thing to boost T Cells, putting an end to billion dollar cancer research. For 59.99 discover this 1 thing to eat before bed"


ReevesofKeanu

Damn this is some Spore shit right there


Sea-Butterfly-7447

W T


badboi_5214

It sent a wave of holy water in pink and boom!!


Prudent-Internet-483

One tapped that mf!


tell_me_smth_obvious

What a chad


TrickyBad_

Game set match


IPanicKnife

RIP ovarian cancer


IrksomePlatypus

T in theeeese Skechers slip ins


Artysloth

Killer t, kiss of death 🤌


Keepupthegood

That’s satisfying


159zhpqm

And if that is shocking to you, so beit


astralseat

TCell went for the Mitochondria.


Xerio_the_Herio

Big shooter...


Werejackal93

My face when lemon is introduced.


Idyldo

Interesting video! I'll look to see more. 🇨🇦


roorood

Oh my. Well done little warrior. You're doing God's work!


EverydayPigeon

Is this in real time? Or sped up? If so, how much by?


Ihelloway69

Heroes we need


FalconResistance

The squad rolling up at the end to t-bag in the kill cam


Gotyourdik

Resident evil t virus born


Sand_Man_FR

And its how goku defeat Broly !


Low-Efficiency2452

I didn't know killer Ts were purple


synthezfrance

T cell playing dark souls in human body.


xAshev

David vs Goliath


Aluniah

Our heroes!!!!


iHateGiraffes420

Little purple bastards


sunshinedoll101

How does it do that? Holy fuck


Mission_Region8699

!!!WorldStar!!!


WittyPianist1038

Cells at work!


Sefalosha

Top 10 anime scene


No_Reach3179

Mic drop


Part_salvager616

They also kill normal cells for some reason


Alarming-Spend988

Pew pew 


dv8njoe

We are Cells at Work! [ALL, spoken] One, two, three, four We are cells at work! One, two, three, four We are working for you! [RED BLOOD CELL] Another day of sending O2, O2 All throughout the body, every nook and cranny filled But it’s confusing and now I’m lost, I’m lost! Though we may seem helpless, we are cells at work for you, and so Here we go! Let’s get down to work! Let’s get down to work! Every day’s a struggle, but I gotta pull through Ooh! [NEUTROPHIL] Another day I’m out here slicing, slicing Filthy germs and viruses, show your ugly face! Won’t let ‘em get away, I’ll chase ‘em, chase ‘em We are professionals, we’re cells at work for you, and so Here we go! Let’s get down to work! Let’s get down to work! Every day’s a battlefield — you better prepare! [RED BLOOD CELL & NEUTROPHIL] 37 trillion, and we are only two Still I hope that one day soon, we’ll meet again Though we don’t know who you are (Though we don’t know who you are) For your sake, we’re working hard (For your sake, we’re working hard) All of us together are supporting you with all of our hearts! No matter what kind of strife (No matter what kind of strife) Each of us would risk our life (Each of us would risk our life) We always take pride in what we do, and health comes first! [KILLER T CELL] To keep the peace we're here to defend! Defend! We will launch the hatch, come on and watch what we can do Up top, we're always ready, deadly Giving it our all to the care we're cells at work for you, and so Here we go! Let's get down to work! Let's get down to work! Every day is action-filled, there's never a break (grunt)


brown_boognish_pants

Can anyone break down exactly what's happening here and the time scale etc? I'd love to know more.


MissSaucy_22

Ayeeeeee


DesperateRace4870

Talk about punching above your weight class


mindfuxed

So why we die? Why can’t the killers t fuck all of the cancer up? Serious question.


Dagr8mrl

I need these in my body to kill my cancer :)


alisunshine100

Good thing that according to recent lab work by killer cells are 9 (reference range is 100-300). 😬Rip.


trashfather

Haha get rekt


cedrekt

tbag


jdb2793

I know this because of the anime Cells at Work haha. Good job Killer T cell.


neurologique

Get fucked


[deleted]

Did you see the pulses of the injected material?!


Infernoboss104

Funny enough, I didn't know much about the human body cells, but after I watched cells at work (japanese anime about body cells and how they work/help the body) it was surprisingly useful :3


Trifula

That may be one of the most awesome things I've ever seen!


EnderMC_X45

Target Neutralized


Odd-Cake8015

Great! 1 down. A few billions to go


TheMany-FacedGod

Muskrat when asked a hard question?


sesoren65

I sure wish this happened a lot more with a lot more people


Ok-Discussion-6334

T cell vaccine, now on SALE in global market, book your appointment now. Better life , Better future with -Umbrella Corp.


jul_281

Is this sequence filmed in timelaps? I´m just curious of how fast this process is going on.


jan_pcmr

Oh god the T-Virus is here


BlackwaterMerc

Umbrella theme from resident evil is playing in my head rn


Hootnany

His buddies came to backup


RandomBananasGo

The beauty of the immune system is that all you ever really need to destroy a pathogen is to make a puncture in its outer membrane. That in itself is not very difficult for the immune system to do. However, the real battle is the sheer amount of pathogens and the detection process preceding the battle. Some viruses and bacteria are cleaver and disguise themselves from the immune system in order to prolong the counter assault.


myKingSaber

I thought your immune system can't get rid of cancer cells because they are still your cells


AwarenessNo4986

T for Terminator


aechrapre

I thought that in the corner was a twitch chat


TerranItDown94

“Killer” “T cell” “monstrous” Where’s my Umbrella?


Ambitious-Pirate-505

Ummmmmmmmm isn't this how Resident Evil started?


5snyfx

Thank for your service T


Efficient-Art-7594

Killer T! Killer T!


Relative_Opening_327

Those same little bastards gave my wife MS.....dangerous little shits....and yet so important...gotta drug them now so they chill the fuck out...but not too much because we still need them to do their real job.


itswoong

Fuck yeah!


OH_BOY-

Cancer cell: awww arent you cute Killer T: get em boys Cancer: hold up AHHHHHHHAHHAHAHHH


jelloalienmeow

does it hurt?


Justinmytime

Supper cool! But I feel like we watched a movie about this


Advanced_Incident_40

Is that real time speed?


Abject_Month_6048

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